mercredi 14 février 2018

Onco Actu du 14 février 2018

1. Biologie

Classification can lead to new ways to diagnose, treat cancer [Baylor College of Medicine]

4.11 Dép., diag. & prono. - Ovaire

The Yet Unrealized Promise of Ovarian Cancer Screening [JAMA Oncology]

4.12 Biopsies liquides

Liquid Biopsies: Past, Present, and Future [ACS]

New cancer test isn't ready for prime time [CNN]

4.9 Dép., diag. & prono. - Sein

Family history increases breast cancer risk even for older women [Reuters]

5. Traitements

Precision Medicine: Hope or Hype? [The ASCO Post]

5.1 Traitements - Pré-clinique

New Cancer Treatment Approach Targets Circadian Clock [NCI]

Molecule Found in Huntington’s Patients Kills Cancer Cells [The Scientist]

Study opens up new way of treating rare cancer of arms and legs [Institute of Cancer Research]

KRAS Targeted Cancer Strategy Shows Early Promise [NIH Director's Blog]

5.10 Traitements - Essais

Data sharing and reanalysis of randomized controlled trials in leading biomedical journals with a full data sharing policy: survey of studies published in The BMJ and PLOS Medicine [BMJ]

5.12 Immunothérapies

Researchers develop novel immunotherapy to target colorectal cancer [Yale News]

5.12.2 Immunothérapies - CAR-T

Toxicity management after chimeric antigen receptor T cell therapy: one size does not fit 'ALL' [Nature Reviews Clinical Oncology]

5.12.5 Immunothérapies - Pharma

Advaxis Submits Conditional Marketing Authorization Application For Axalimogene Filolisbac For The Second-Line Treatment Of Metastatic Cervical Cancer In European Union [Advaxis]

5.2 Pharma

Exelixis Announces Results from a Phase 2 Investigator-Sponsored Trial of Cabozantinib in the First-Line Treatment of Metastatic Radioiodine-Refractory Differentiated Thyroid Carcinoma [Exelixis]

Erytech Selects Triple Negative Breast Cancer As Next Indication For Eryaspase [Erytech]

Erytech doubles down on solid tumor trials for red cell drug therapy [FierceBiotech]

5.2.3 Pharma - économie

Drug copies ready to take next bite out of Roche's cancer sales [Reuters]

5.3 Traitements - FDA, EMA, NICE...

Statement from FDA Commissioner Scott Gottlieb, M.D., on Administration’s request for new FDA funding to promote innovation and broaden patient access through competition [FDA]

5.4 Traitements - Economie

Trump's Budget Proposal Swings At Drug Prices But May Land Only A Glancing Blow [NPR]

$100B in NIH-funded research played an important role in all 210 new drugs approved over 7 years — study [EndPoints]

5.5.3 ASCO (prostate)

Richard Lehman’s journal reviews—12 February 2018 - Et tu, apalutamide [BMJ]

6. Lutte contre les cancers

Precision Medicine for Everyone [NEJM Catalyst]

6.1 Observation

Obesity Tied to Survival in Men With Melanoma [NY Times]

6.11 Patients

'My sister died of lung cancer but never smoked' [BBC News]

6.4 Médico-éco

Lives hang in the balance as health insurers drag their feet on coverage appeals [STAT]

High cancer-related expenses take a toll on quality of life [Reuters]

6.6 Publications

Q&A John Ioannidis: Biomedicine warms to preprints [Nature]