jeudi 11 janvier 2018

Onco Actu du 11 janvier 2018

1. Biologie

Epigenetics: How It Works And What It Means for Cancer Research [Dana-Farber Cancer Institute]

3.1 Prévention - Tabac

7 in 10 people who try a cigarette become daily smokers, study suggests [Cancer Research UK]

4. Dépistage, diagnostic et pronostic

Chromosomal Instability in Cancer [ESMO]

4.1 Dép., diag. & prono. - Prostate

£100 gene tests could identify men with three times the chance of deadly prostate cancer [The Telegraph]

5. Traitements

AI in drug discovery is overhyped: examples from AstraZeneca, Harvard, Stanford and Insilico Medicine [The AI Lab]

Objections to (Some) Drug Discovery AI [In the Pipeline]

5.12.2 Immunothérapies - CAR-T

Bluebird hopes for 3 drug approvals by 2019, including CAR-T and gene therapies [EndPoints]

5.12.3 Immunothérapies-combinaisons

Genentech, Syndax expand HDAC-PD-L1 combination pact [FierceBiotech]

Genentech adds a new program for Syndax’s lead cancer drug to its Tecentriq combo platform [EndPoints]

5.2 Pharma

Novartis appoints Elizabeth Barrett as Oncology Head [Novartis]

GSK’s long-quiet cancer R&D group is ready to make some noise as it mounts a breakout late-stage effort [EndPoints]

5.3 Traitements - FDA, EMA, NICE...

CDER Report on Novel Approvals Highlights Firsts in 2017 [RAPS]

Federal Right-to-Try Legislation — Threatening the FDA’s Public Health Mission [NEJM]

5.9.5 IASLC

Chemoradiation in Elderly Patients with Stage III NSCLC Improves Overall Survival [IASLC]

6. Lutte contre les cancers

Many women uninformed about breast cancer surgery options [Reuters]

6.1 Observation

New treatments, screening methods dramatically reduce breast cancer deaths [Stanford Medicine]

Cancer Deaths Continue to Decline [Science-Based Medicine]

6.6 Publications

Why Elsevier is a Library’s Best Friend [The Scholarly Kitchen]

Funders should mandate open citations [Nature]

A Big Brother future for science publishing? [BMJ]

6.7 DMP, Big Data & applis

CancerLinQ LLC Partners with the National Society of Genetic Counselors [ASCO]