Onco Actu du 5 décembre 2017

	1. Biologie
Immune cells share their insides with tumors to promote cancer spread [Fred Hutch] New study in zebrafish and mice shows immune cells interact with melanoma and transfer their contents to spur metastasis.
	2.7 Etiologie - Obésité
Take a Number: Two Hidden Cancer Causes: Diabetes and Obesity [NY Times] Researchers compared incidence data for 12 cancers in 175 countries in 2012 with body mass index and diabetes prevalence figures from 2002, on the assumption that it takes at least ten years for cancer to develop.
	4.10 Dép., diag. & prono. - FDA, EMA, NICE,...
Statement by FDA Commissioner Scott Gottlieb, M.D., on FDA ushering in new era of 3D printing of medical products; provides guidance to manufacturers of medical devices [FDA] The agency is the first in the world to provide a comprehensive technical framework to advise manufacturers creating medical products on 3D printers.
	5.1 Traitements - Pré-clinique
Fat Cells May Hinder Effectiveness of Chemotherapy [NCI] As the study authors wrote, the ability of fat cells to absorb and even break down certain cancer drugs could reduce the concentration of active drugs in tumor microenvironments rich in fat cells, potentially contributing to the emergence of drug-resistant tumor cells.
	5.12.2 Immunothérapies - CAR-T
CRISPR/Cas9 pioneer Chad Cowan enlists in Mustang Bio’s CAR-T quest [EndPoints] Mustang also in-licensed CRISPR/Cas9 tech from Harvard to use on off-the-shelf CAR-T drugs as Novartis and Gilead/Kite roll out the first personalized drugs in the field.
	5.3.4 Traitements - AMM (FDA, EMA)
Mylan's Ogivri becomes first and only FDA-approved Herceptin biosimilar [Pharmafile] Ogivri also secured authorisation in India in 2014 as well as 18 other countries, but it is still awaiting approval in a number of markets, including Europe, Australia and Canada.
	5.7 SABCS
SABCS Marks 40 Years [Cancer Research Catalyst] Symposium organizers will commemorate the anniversary in numerous ways, including the SABCS 40th Anniversary Award Lecture, to be presented this Wednesday by Richard Pazdur, MD, director of the U.S. Food and Drug Administration Oncology Center of Excellence.
	5.9 AACR
Loxo, Bayer maintain 90%-plus response rate in cancer trial [FierceBiotech] Loxo now has more than a year of follow-up data on four subjects and more than six months of results on 12 participants, bolstering its belief in the durability of the patients’ responses to its drug.
Updated larotrectinib pediatric clinical trial data demonstrate continued durability of response in TRK fusion cancers [Bayer] 93 percent overall response rate in 17 pediatric patients with TRK fusion cancers.
	6. Lutte contre les cancers
NHS cancer experts recruited in their hundreds to speed up diagnosis [The Telegraph] Ministers will promise to recruit 300 radiographers - specialists who use x-rays and ultrasound to identify certain cancers - and 200 clinical endoscopists, who investigate areas such as the bowel and stomach, using special cameras.
	6.5 Médecines alternatives
Integrating pseudoscience and mysticism into oncology in bastions of evidence-based medicine [Respectful Insolence] Until the Society for Integrative Oncology can eliminate its blindspots over all the quackery that is included in “integrative medicine,” its claims of being scientifically rigorous are just so much self-delusion.
	6.6 Publications
Federal Trade Commission and National Institutes of Health Take Action Against Predatory Publishing Practices [The Scholarly Kitchen] It’s worth noting, again, that the publishing practices about which both the FTC and the NIH are complaining don’t particularly concern “quality” — scholarly rigor and selectivity — itself. They are much more specifically about deceptive business practices.
	6.7.1 Bioinformatique
Tapping the genome's social network to find cancer drivers [Broad Institute] A new computational tool merges cancer genome and protein interaction data to find cancer-fueling mutations more effectively.
Google Has Released an AI Tool That Makes Sense of Your Genome [MIT Technology Review] Last year, DeepVariant won first place in the PrecisionFDA Truth Challenge, a contest run by the FDA to promote more accurate genetic sequencing.
	6.9 Controverses
Investors see big money in infertility. And they’re transforming the industry [STAT] Then there’s egg freezing, a procedure pioneered for women trying to preserve their fertility before undergoing cancer treatments. In the last few years, it’s been rebranded as option for women who intend to put off pregnancy, perhaps because they want to pursue their careers or haven’t yet found a partner during their prime reproductive years.