vendredi 1 décembre 2017

Onco Actu du 1er décembre 2017

1. Biologie

Invasive cells in head and neck tumors predict cancer spread [Mass. General Hospital]

Communication between lung tumors and bones contributes to tumor progression [Mass. General Hospital]

Mapping Terra Incognita [Harvard Medical School]

Semi-Synthetic Life Form Now Fully Armed and Operational [MIT Technology Review]

2.5 Etiologie - Gènes

Genetic link found between the immune system and lymphoma [Institute of Cancer Research]

4. Dépistage, diagnostic et pronostic

Cancer x-ray services to be reviewed after serious diagnostic failures [The Guardian]

4.10 Dép., diag. & prono. - FDA, EMA, NICE,...

Foundation's cancer gene test gets U.S. FDA and Medicare nod [Reuters]

FDA announces approval, CMS proposes coverage of first breakthrough-designated test to detect extensive number of cancer biomarkers [FDA]

4.5 Dép., diag. & prono. - Colorectal

Study Suggests Measurable Impact of Colorectal Cancer Screening Program [ACS]

4.7 Dép., diag. & prono. - Col de l'utérus

Australia's new cervical cancer test 'much more sensitive' – Cancer Council [The Guardian]

5. Traitements

Tackling ‘undruggable’ genes in lung and pancreatic cancers is this researcher’s life [Cancer Research UK]

5.10 Traitements - Essais

Phase III trial of radium-223 dichloride in combination with abiraterone acetate and prednisone/prednisolone for patients with metastatic castration-resistant prostate cancer unblinded early [Bayer]

5.12 Immunothérapies

CRISPR Enables Cancer Immunotherapy Drug Discovery [Dana-Farber Cancer Institute]

Cancer drug offers tantalising hope for HIV cure [The Guardian]

Cancer drug prompts 'drastic' HIV decrease in lung cancer patient [Reuters]

5.12.3 Immunothérapies-combinaisons

Immune-boosting antibody combination could improve lymphoma survival [Cancer Research UK]

5.12.4 Immunothérapies - Essais

CheckMate -078, a Pivotal, Multinational Phase 3 Opdivo (nivolumab) Lung Cancer Trial with Predominantly Chinese Patients, Stopped Early for Demonstrating Superior Overall Survival [BMS]

5.2.2 Pharma - Fusions & Acquisitions

After all the love and money, analysts speculate that J&J may swoop in with a buyout offer for Genmab [EndPoints]

5.2.3 Pharma - économie

Judge upholds $110M J&J talc verdict, despite SCOTUS jurisdiction ruling [FiercePharma]

5.3 Traitements - FDA, EMA, NICE...

Remarks from FDA Commissioner Scott Gottlieb, M.D., as prepared for oral testimony before the House Committee on Energy and Commerce Hearing, “Implementing the 21st Century Cures Act: An Update from FDA and NIH" [FDA]

Cures Act implementation: Gottlieb says faster cancer drug approvals coming for secondary indications [EndPoints]

FDA aims to approve more drugs based on early clinical data [Reuters]

Time from US Food and Drug Administration approval to publication of data for cancer drugs: a comparison of first and subsequent approvals [Blood Cancer Journal]

5.3.4 Traitements - AMM (FDA, EMA)

Dasatinib Approved by FDA for Some Children with Chronic Myelogenous Leukemia [NCI]

5.4 Traitements - Economie

Making Medicines Affordable: A National Imperative (2017) [National Academies Press]

ASCO Applauds New Report on Making Medicines Affordable [ASCO]

Exclusive: U.S. health regulator Verma eyes new methods for drug pricing [Reuters]

6. Lutte contre les cancers

More than One-Third of Physician Assistants in Oncology Experience Burnout, Despite High Rate of Career Satisfaction, New Study Finds [ASCO]

6.3 Associations/Fondations

Major charity under fire for pharma ties and may close up shop [FiercePharma]

6.9 Controverses

Statistics controversy: missing the p-oint [The Mermaid's Tale]