Onco Actu du 24 novembre 2017

	1. Biologie
Tumour-associated bacteria hitches a ride to metastatic sites [ecancernews] To explore whether colon cancer that has spread to other parts of the body also harbours the bacteria, Susan Bullman et al. analyzed samples of primary tumours and corresponding liver metastases in colon cancer patients.
Why Is This Bacterium Hiding in Human Tumors? [NY Times] Whether the bacterium, called Fusobacterium nucleatum, actually plays a role in causing or spurring the growth of cancer is not known. But the new study, published in the journal Science, also shows that an antibiotic that squelches this organism slows the growth of cancer cells in mice.
	5.10 Traitements - Essais
Experimental drug trial seeks to improve treatment for head and neck cancer [Cancer Research UK] Researchers want to find out whether using Astra Zeneca’s AZD1775 experimental compound, in combination with chemotherapy before surgery or with chemotherapy and radiotherapy after surgery, is more effective and reduces the risk of the cancer returning.
	5.12 Immunothérapies
ESMO Immuno-Oncology Congress In Europe To Provide Answers To Open Questions In Cancer Immunotherapy [ESMO] The event is the premier I-O meeting in Europe for basic, translational and clinical researchers, immunologists, oncology clinicians and other professionals, attracting one thousand attendees who will benefit from a broad and varied programme as well as focused sessions dedicated to different tumour types and key aspects of this treatment modality.
	5.3.4 Traitements - AMM (FDA, EMA)
European Medicines Agency approves abiraterone combined with hormone therapy as first-line treatment for advanced prostate cancer [institute of Cancer Research] Abiraterone was discovered at The Institute of Cancer Research, London, and had already previously been approved for the treatment of advanced prostate cancer before chemotherapy in men for whom hormone therapy had failed.
	6. Lutte contre les cancers
How to survive the cruel world of peer-reviewed funding applications [LSE Impact Blog] There is also advice for the funding agencies themselves on what they can do to make the process more dynamic and efficient.
	6.7 DMP, Big Data & applis
Data and context is key for robust A.I. in health [PHG] Sobia used the analogy of driverless cars, which may have been trained and then successfully tested on broad open highways in California but are faced with a very different set of decisions on narrow British country lanes. She said ‘It’s the same in healthcare – the A.I. algorithms have to be tested under the conditions and the population in which they will be used.’