mercredi 22 novembre 2017

Onco Actu du 22 novembre 2017

2.9 Etiologie - Tabac

Smoking – particularly if started during adolescence – is associated with an increased risk of breast cancer, major new study finds [Institute of Cancer Research]

3. Prévention

Nearly half of U.S. cancer deaths blamed on unhealthy behavior [STAT]

New Study Calculates Contribution of Smoking, Poor Diet, Obesity, and Other Modifiable Risk Factors to Cancer in the United States [ACS]

3.1.1 Prévention - Tabac - e-cigs

Tobacco Product Manufacturing Practice; Request for Comments [Federal Register]

3.7 Prévention - Alcool

Minimum alcohol pricing in Scotland to start in May [BBC News]

Alcohol and cancer [The Lancet]

4.2 Dép., diag. & prono. - Génome

Genomenon Creates Automated, Evidence-Based Cancer Gene Panel [Xconomy]

4.9 Dép., diag. & prono. - Sein

Breast cancer tumours 'larger' in overweight women [BBC News]

5.10 Traitements - Essais

Negligible Benefit Of Nerlynx, A New Breast Cancer Drug, Calls For Caution [Forbes]

5.12.2 Immunothérapies - CAR-T

Stanford trial points to a new CAR-T drug, spotlighting a fresh target for next-gen cell therapies [EndPoints]

New target for CAR T cell leukemia therapy “gives hope” to researchers at Stanford, NCI [Stanford Medicine]

New Gene Treatment Effective for Some Leukemia Patients [NY Times]

5.12.7 Immunothérapies - vaccins

Experimental Ovarian Cancer Vaccine Shows Promise in Mice [NCI]

5.2 Pharma

Roche Cancer Drug Rises To Challenge Merck, Bristol-Myers [Forbes]

Lacking Details, Roche Touts Drug Combo’s Success in Lung Cancer [Xconomy]

Roche's Two Good-News Scoops May Have a Short Shelf Life [Bloomberg]

Roche shares surge as a double-shot win in I/O and hemophilia raises blockbuster expectations [EndPoints]

Phase III IMpower150 Study Showed Genentech’s Tecentriq (Atezolizumab) and Avastin (Bevacizumab) Plus Chemotherapy Significantly Reduced the Risk of Disease Worsening or Death in the Initial Treatment of People with a Type of Advanced Lung Cancer [Genentech]

Roche stock up $12 billion on cancer, hemophilia trials; rivals hit [Reuters]

5.2.1 Pharma - Partenariats

Boehringer Ingelheim makes many of its best molecules openly available to the scientific community via to unlock their full potential [Boehringer Ingelheim]

5.2.3 Pharma - économie

Fighting Cancer One Patient At A Time [Forbes]

5.3 Traitements - FDA, EMA, NICE...

Brexit gets real for drugmakers as regulator moves to Amsterdam [Reuters]

After unexpected tie, Amsterdam wins ‘coin toss’ for new EMA HQ [EndPoints]

European Medicines Agency will move to Amsterdam [Science]

Amsterdam, Paris win post-Brexit EU agencies in lucky dip [Reuters]

EMA to relocate to Amsterdam, the Netherlands [EMA]

5.3.4 Traitements - AMM (FDA, EMA)

Novartis drug Tasigna® (nilotinib) secures EU approval for first and second-line treatment of Ph+ CML-CP in children [Novartis]

European Commission Extends License for Janssen’s ZYTIGA Plus Prednisone / Prednisolone to Include Earlier Stage Prostate Cancer Patients [Janssen]

Guideline on the evaluation of anticancer medicinal products in man [EMA]

5.4 Traitements - Economie

Bayer’s Stivarga wins NICE approval for GIST [PharmaTimes]

5.5.5 ASCO (gastro-intestinal)

Exelixis Announces Phase 3 CELESTIAL Trial Results of Cabozantinib in Previously Treated Advanced Hepatocellular Carcinoma to be Presented at 2018 Gastrointestinal Cancers Symposium [Exelixis]

5.8.5 ASH - Myélome multiple

Janssen Submits Application to U.S. FDA to Expand Indication for DARZALEX (daratumumab) Combination Therapy for Patients with Newly Diagnosed Multiple Myeloma who are Transplant Ineligible [Janssen]

Johnson & Johnson drug succeeds in newly diagnosed multiple myeloma patients: study [Reuters]

5.8.6 ASH - Leucémies

Phase 3 MURANO Study of Venetoclax Chosen as Late-Breaking Abstract at the 2017 American Society of Hematology Annual Meeting & Exposition, Highlighting AbbVie's Commitment to Helping Blood Cancer Patients [AbbVie]

LBA-2 Venetoclax Plus Rituximab Is Superior to Bendamustine Plus Rituximab in Patients with Relapsed/ Refractory Chronic Lymphocytic Leukemia - Results from Pre-Planned Interim Analysis of the Randomized Phase 3 Murano Study [ASH]

Roche, AbbVie leukemia drug superior to older medicine in study [Reuters]

6. Lutte contre les cancers

People Willing to Trade Treatment Efficacy for Reduced Side Effects in Cancer Therapies [ASH]

6.1 Observation

Endometrial Cancer Incidence Rising in the US and Worldwide [NCI]

Skin Cancers Rise, Along With Questionable Treatments [NY Times]

6.10 Politiques

Bowel screening and car park cancer scans: what you need to know about the latest NHS announcements [Cancer Research UK]

NHS England announces plans to break down barriers for research [NHS England]

Cancer patients 18 times more likely to survive with early diagnosis [The Telegraph]

6.11 Patients

‘It’s about love’: Battling a brain tumor, a man finds resilience through storytelling [STAT]

1 in 5 shows PTSD symptoms after cancer diagnosis, study finds [STAT]

Some cancer patients have PTSD years after diagnosis, study finds [BBC News]

Living With Cancer: Giving Thanks for Survivors [NY Times]

6.5 Médecines alternatives

Why do some breast cancer patients decline chemotherapy and radiation? [Respectful Insolence]

6.6 Publications

Online software spots genetic errors in cancer papers [Nature]

6.7 DMP, Big Data & applis

Stanford-Google digital-scribe pilot study to be launched [Stanford Medicine]