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1. Biologie
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A Zombie Gene Protects Elephants for Cancer [Wired]
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“We
think that LIF6 is a refunctionalized pseudogene,” Lynch said. That is,
the elephant LIF6 re-evolved into a functional gene from a pseudogene
ancestor. Because it came back from the dead and plays a role in cell
death, Lynch called it a “zombie gene.”
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2. Etiologie
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2.10 Etiologie - Alcool
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2.6 Etiologie - Environnement
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Glyphosate and the Regulatory Failure of Precaution [The Risk-Monger]
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If
the European Member States cannot reach a qualified majority either way
on the renewal of glyphosate, then the Commission has the right and the
obligation to rise above the politics of the interest groups, support
the overwhelming evidence of its scientific agencies and renew the
herbicide for the proposed ten years in chambers.
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3.1 Prévention - Tabac
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Tobacco Product Use Among Adults — United States, 2015 [MMWR-CDC]
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Despite
the popularity of emerging products such as pipes, water pipes,
hookahs, and e-cigarettes among youths, these findings highlight the
importance of also continuing to use targeted evidence-based,
population-level strategies to combat combustible product use.
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Advances in Tobacco Control [Cancer Research Catalyst]
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These
grim statistics highlight the need for new tobacco control initiatives.
One legislative tobacco control initiative that came into effect on
Nov. 1 in New Jersey is an increase in the minimum age of legal access
to all tobacco products to 21.
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1 in 5 U.S. adults used tobacco in 2015: government study [Reuters]
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The
survey showed rates of use of any tobacco product were higher among
adults living in the Midwest; people with a high-school equivalency
diploma; those with annual household incomes below $35,000; adults
uninsured or insured through Medicaid, the federal insurance program for
the poor; people with a disability; and those who are lesbian, gay or
bisexual.
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4.12 Biopsies liquides
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4.13 Dép., diag. & prono. - Peau
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4.7 Dép., diag. & prono. - Col de l'utérus
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5.1 Traitements - Pré-clinique
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Fat Cells May Inactivate Chemotherapeutic Drug [AACR]
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Mittelman
and colleagues sought to examine how obesity might alter the
effectiveness of daunorubicin. They cocultured human acute lymphoblastic
leukemia (ALL) cell lines with adipocytes and treated them with
daunorubicin. They also studied whether human adipose tissue from cancer
patients could metabolize daunorubicin.
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Study Identifies Potential Drug Combination for Ewing Sarcoma [NCI]
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One
of the drugs, vincristine, is a chemotherapy agent that is part of the
standard treatment for patients with Ewing sarcoma. The other, YK-4-279,
is an experimental drug that targets an abnormality, called a fusion
protein, that is commonly found in Ewing sarcoma tumors.
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5.12 Immunothérapies
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5.12.2 Immunothérapies - CAR-T
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When Small Trials Convince [In the Pipeline]
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But
in things like CAR-T therapy for cancer, the long-term effects are
still an open question, because there aren’t any really long-term
beneficiaries yet. It’ll be years before we know for sure. The
mitigating factor there, of course, is that without the CAR-T treatment
these people, every single one of them, would be long dead.
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5.12.3 Immunothérapies-combinaisons
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5.12.9 Immunothérapies - SITC
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Juno Dissects ROCKET Deaths, Will Aim Better CAR-T at Leukemia [Xconomy]
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The
report, presented today at the Society for Immunotherapy of Cancer
conference near Washington, DC, explains why the study participants, all
with advanced acute lymphoblastic leukemia (ALL) that had resisted
other treatments, succumbed unexpectedly to severe brain swelling, known
as cerebral edema.
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SITC Scientific Highlights - Nov. 11 [The Sentinel]
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- Dendritic cell acquisition of MHC I controls CD8+ T cell priming -
Risk/benefit ratio differs between checkpoint inhibitor monotherapy and
combination therapy in the neoadjuvant setting in patients with
advanced melanoma -...
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SITC Scientific Highlights - Nov. 10 [The Sentinel]
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- Co-administration of novel anti-sMIC antibody increases anti-CTLA-4 therapeutic response in TRAMP/MIC mice (O22) - Anti-PD-1 agent nivolumab shows promise in solid tumor patients selected for treatment according to biomarker status (O37) -...
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5.2.3 Pharma - économie
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5.3 Traitements - FDA, EMA, NICE...
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5.3.4 Traitements - AMM (FDA, EMA)
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Adcetris [EMA]
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The
CHMP adopted a new indication as follows: "Adcetris is indicated for
the treatment of adult patients with CD30+ cutaneous T-cell lymphoma
(CTCL) after at least 1 prior systemic therapy (see section 5.1)."
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5.4 Traitements - Economie
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6. Lutte contre les cancers
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6.1 Observation
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6.10 Politiques
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6.6 Publications
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6.8 Communication
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