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1.4 Biologie - Technos
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Bitter CRISPR patent war intensifies [Nature]
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Overall,
there are more than 1,880 families of CRISPR patent, according to
IPStudies, a consulting firm near Lausanne, Switzerland. More than 100
new families — each a group of related intellectual-property claims —
are published each month.
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2 new CRISPR tools overcome the scariest parts of gene editing [Vox]
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“These
are fairly sophisticated technologies, and it takes a decent amount of
knowhow to be able to operate them,” said Zhang. “But even more
importantly, biology is very complicated. We are having a difficult time
just treating diseases that are caused by a single mutation. There’s
lots of biology we need to [learn] to be able to engineer biology.”
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2.5 Etiologie - Gènes
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3.1 Prévention - Tabac
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Tobacco Use Among Working Adults — United States, 2014–2016 [MMWR-CDC]
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Overall,
a decline in cigarette smoking, smokeless tobacco, and e-cigarette use
was observed among U.S. workers. However, tobacco use varied by product
type, sociodemographic characteristics, and industry and occupation,
with a higher prevalence of any tobacco use among workers in the
construction industries and installation, maintenance, and repair
occupations.
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4. Dépistage, diagnostic et pronostic
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4.2 Dép., diag. & prono. - Génome
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5.12.1 Immunothérapies - partenariats
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5.12.2 Immunothérapies - CAR-T
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5.12.8 Immunothérapies - Economie
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5.2.3 Pharma - économie
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5.3 Traitements - FDA, EMA, NICE...
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FDA considers Avastin as first-line ovarian cancer therapy [PharmaTimes]
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The
application is based on data from the pivotal Phase III GOG-0218 trial,
in which women who received Avastin in combination with chemotherapy,
and continued use of Avastin alone for a total duration of 22 cycles,
had a median progression-free survival (PFS) of 18.2 months compared to
12.0 months in women who received chemotherapy alone.
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5.3.4 Traitements - AMM (FDA, EMA)
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Abemaciclib Approved by FDA for Advanced or Metastatic Breast Cancer [NCI]
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Of
the three CDK4/6 inhibitors now approved, abemaciclib may be the one
that binds to CDK4 the best, Dr. Brufsky said. However, despite the
clinical effectiveness of the drug, there is a “substantial” chance it
will cause severe diarrhea as a side effect, he said, affecting 10% to
15% of patients.
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5.9 AACR
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How the immune system spots cancer [YouTube]
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Cancer
Research UK scientists (as part of the TRACERx trials) have developed a
computational toolset to help investigate how many of these signals to
the immune cells are left on a cancer cell, based on DNA sequencing
information.
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6.1 Observation
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6.7 DMP, Big Data & applis
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