jeudi 26 octobre 2017

Onco Actu du 26 octobre 2017

1. Biologie

Brain tumours’ shared metabolic tricks hint at new approach to treatment [Cancer Research UK]

1.4 Biologie - Technos

CRISPR hacks enable pinpoint repairs to genome [Nature]

CRISPR toolbox gets two new molecular gadgets, boosting gene-editing [STAT]

CRISPR-based method allows for reversible RNA editing [FierceBiotech]

'Chemical surgery' can correct genetic mutations behind many diseases – study [The Guardian]

Base Editing Now Able to Convert Adenine-Thymine to Guanine-Cytosine [The Scientist]

CRISPR Pioneer Zhang Details New Editing System Downstream From DNA [Xconomy]

CRISPR 2.0 Is Here, and It’s Way More Precise [MIT Technology Review]

Novel CRISPR-derived ‘base editors’ surgically alter DNA or RNA, offering new ways to fix mutations [Science]

Researchers Unveil New Techniques For Editing Genes [Forbes]

5. Traitements

Proton therapy may be better option for elderly patients with esophageal cancer [Mayo Clinic]

5.1 Traitements - Pré-clinique

A rare disease inspires Stanford researchers to find a new way to attack cancer [Stanford]

5.12 Immunothérapies

Fred Hutch researchers engineer complex TCR immunotherapy that may target relapsing leukemia [Fred Hutch]

5.12.1 Immunothérapies - partenariats

Incyte pays MacroGenics $150M for PD-1 inhibitor [FierceBiotech]

5.12.2 Immunothérapies - CAR-T

With FDA Approval for Advanced Lymphoma, Second CAR T-Cell Therapy Moves to the Clinic [NCI]

5.2 Pharma

Terminated Blood Cancer Drug Springs Back to Life at SD Biotech [Xconomy]

5.3 Traitements - FDA, EMA, NICE...

Sandoz raises questions with FDA draft guidance on statistical approaches for biosimilars [EndPoints]

6. Lutte contre les cancers

Stand Up To Cancer Launches Four Teams on “Cancer Interception” To Detect and Treat Cancer at Earliest Stages [AACR]

National Survey Reveals Most Americans Are Unaware of Key Cancer Risk Factors [ASCO]

6.1 Observation

Cancer patients diagnosed at an earlier stage are more likely to have surgery than chemotherapy [Cancer Research UK]

Depression, fatigue tied to more hospital stays for terminal cancer [Reuters]

6.10.1 Politiques (USA)

Key legislator tells Trump officials to back off on proposed overhead spending cap for NIH [Science]

6.6 Publications

Widely used U.S. government database delists cancer journal [Retraction Watch]

Global co-authors on more than half of French and UK research [Times Higher Education]

6.9 Controverses

Innovation in research provides benefits to society and the economy… but how do we measure it? [Institute of Cancer Research]