Onco Actu du 7 juillet 2017

Pour info : Onco Actu interrompt sa parution pendant une semaine.

	1. Biologie
Lymph node metastases may not always be the source of cancer's spread to other organs [Mass. General Hospital] In their report in the July 7 issue of Science, the researchers describe finding that, for the majority of colorectal cancer patients in the study, “distant” metastases originated directly from the primary tumor, independent of any lymph node metastases.
	2.10 Etiologie - Alcool
Alcohol and Digestive Cancers [UEG] Canvassing the opinions of leading European digestive cancer specialists, stakeholder organisations and patient groups, the report highlights the scale of alcohol consumption across Europe and its direct and indirect impact on digestive cancers.
	3. Prévention
Frequent ejaculation may decrease prostate cancer risk [NHS Choices] Aside from ejaculating frequently, other methods that may help reduce your risk of prostate cancer include achieving or maintaining a healthy weight, and regular exercise.
	3.1 Tabac
France to become one of priciest countries in Europe for smokers [Reuters] "France is one of the slowest learners in the world on smoking," the minister, Agnes Buzyn, said. "Big price rises will be needed to have an impact on public health."
	3.7 Alcool
Alcohol industry isn’t just funding studies; it’s also funding journalism to sway public opinion [HealthNewsReview] Should journalists who attend the alcohol industry-funded workshops, some of whom may eventually report on this study, disclose that they attended a workshop with expenses covered by the alcohol industry?
	4.12 Biopsies liquides
Simple test predicts return of bladder cancer [Cancer Research UK] Researchers from the University Hospital of Lyon tested the urine of 348 bladder cancer patients* for a faulty protein called TERT, and this was able to predict when the cancer was about to return in more than 80 per cent of patients.
	5. Traitements
Real-World Evidence Generation and Evaluation of Therapeutics: Proceedings of a Workshop (2017) [NAP] In October 2016, the National Academies of Sciences, Engineering, and Medicine held a workshop to facilitate dialogue among stakeholders about the opportunities and challenges for incorporating real-world evidence into all stages in the process for the generation and evaluation of therapeutics. Participants explored unmet stakeholder needs and opportunities to generate new kinds of evidence that meet those needs.
Cancer Researchers Report Progress in Studying Exceptional Responders [NCI] The Exceptional Responders pilot study aims to include 100 patients with confirmed exceptional responses to treatment. More than 40 cases have been analyzed to date.
	5.12.1 Immunothérapies - partenariats
Celgene Builds Up Cancer Drug Pipeline With BeiGene Deal [Xconomy] BeiGene has taken BGB-A317 into two late-stage clinical trials in China. The company says the drug has shown the ability to work on a range of solid tumor types. Global clinical studies for the drug are planned for next year.
Celgene is Tardy to This Cancer-Drug Party [Bloomberg] Celgene spent big for the chance to enter a market that's already crowded and due to become increasingly fragmented.
	5.12.2 Immunothérapies - CAR-T
Oxford BioMedica and Novartis build on supply deal as CAR-T medication nears finish line [FiercePharma] Novartis, which noted some manufacturing issues when it recently released data from its Juliet trial, has said it expects to be able to complete the process in about 22 days at the time of commercial launch.
Sophie’s Choice for Oncologists: Who Gets New Life-Saving Drug [Bloomberg] First CAR-T therapy soon approved, but production roadblocks. Some dying patients won’t get it in time: ‘God, it’s awful’.
	5.12.4 Immunothérapies - Essais
FDA Suspends Certain Clinical Trials of Merck’s Keytruda [Wall Street Journal] Keytruda had sales of $1.4 billion in 2016, which are expected to grow this year as the drug has been approved for additional uses, including to treat any tumor with a certain genetic mutation.
	5.12.7 Immunothérapies - vaccins
Glimmers of hope for cancer vaccines as two neoantigen shots hit the mark [FierceBiotech] It's a massive boost for Mainz-based BioNTech and an early positive readout for the company and its partners, including Sanofi and Roche subsidiary Genentech, which have agreed to stump up hundreds of millions of dollars to push the technology.
Personalised vaccines to treat skin cancer show promise in small studies [Cancer Research UK] The results will be seen as another step towards personalised therapies, though vaccines are some way off being used as a standard treatment.
	5.2.3 Pharma - économie
New data shows pharma has not cut back on contraversial payments to physicians [Pharmafile] Despite increasing controversy arising over the years due to the questionable relationship between physicians and pharma and the money which flows between them, and amid calls for greater transparency of spending and practice, new data from the US government’s Open Payments database suggests that non-research funding spent by pharma companies has not dropped.
	5.4 Traitements - Economie
Innovative therapies require innovative thinking on access and cost [STAT] These proposals build on a shared commitment to put patients first and form part of the bipartisan common ground to help ensure that our health care system delivers highly effective and affordable care to all Americans.
	6. Lutte contre les cancers
Enhancing Fertility Preservation for Childhood Cancer Patients [Oncology Times] The analysis of 921 female survivors in the St. Jude Lifetime Cohort Study (St. Jude LIFE) found that abdominal radiation, no matter what the dose, puts female survivors at high risk for premature ovarian insufficiency.
	6.1 Observation
Nearly Half of China Cancer Deaths Attributable to Modifiable Risk Factors [ACS] Cancer is the leading cause of death in China, with 4.3 million new cancer cases and 2.8 million cancer deaths estimated to occur each year.
Drop in cancer deaths in rural America slower than urban areas: CDC [Reuters] For cancers that are often associated with tobacco use such as lung or those that can be diagnosed through early screenings, including colorectal and cervical, the rate of incidence is higher in rural areas, the report said.
	6.4 Médico-éco
Narrow health insurance networks more likely to exclude top cancer docs [Reuters] It's not clear whether a narrow network affects the quality of care people receive, but the researchers say the limited selection may cut access to high-quality providers like those at NCI-Designated Cancer Centers.
	6.6 Publications
Fake peer review, forged authors, fake funding: Everything’s wrong with brain cancer paper [Retraction Watch] A 2015 paper is the latest retraction stemming from an investigation into fake peer review by Springer, which has now netted more than a hundred papers.
	6.7.1 Bioinformatique
How AI detectives are cracking open the black box of deep learning [Science] Some tools probe the AI without penetrating it; some are alternative algorithms that can compete with neural nets, but with more transparency; and some use still more deep learning to get inside the black box.
	6.7.2 Applis
Use of WhatsApp in NHS 'widespread', say doctors [BBC News] The healthcare body needed to act swiftly to address the issue, or potentially face huge fines for data breaches, said Forrester analyst Kate McCarthy.
	6.9 Controverses
How a Civil War-era law is being used to punish scientific fraudsters [STAT] The suit is the latest attempt to use a 19th-century law for relatively new purposes: putting universities on the hook for grant money that went to researchers found guilty of fraud.