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3.1 Tabac
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Tobacco control plan for England published [Cancer Research UK]
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While
no date is set, the plan’s ambition is to reduce smoking prevalence to
below 5 in 100 people. If this was achieved by 2035, the NHS could save
£67million per year, avoiding 97,500 new cases of smoking-related
disease, including 35,900 cancers over 20 years.
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3.3 Prévention - Vaccins
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Plan not to give HPV vaccine to boys causes concern [BBC News]
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"While
there are some additional benefits to vaccinating both males and
females, the current models indicate that extending the programme to
boys in the UK, where the uptake in adolescent girls is consistently
high (over 85%), would not represent a good use of NHS resources."
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4.12 Biopsies liquides
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5. Traitements
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5.10 Traitements - Essais
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5.12 Immunothérapies
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Making cancer vulnerable to immune attack [Harvard Gazette]
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In
findings published online by Nature, the Dana-Farber/Boston Children’s
team — led by pediatric oncologist W. Nick Haining — reports that
deletion of the Ptpn2 gene in tumor cells made them more susceptible to
PD-1 checkpoint inhibitors.
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5.12.2 Immunothérapies - CAR-T
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5.12.5 Immunothérapies - Pharma
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5.2.1 Pharma - Partenariats
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5.2.3 Pharma - économie
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5.3 Traitements - FDA, EMA, NICE...
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5.3.4 Traitements - AMM (FDA, EMA)
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5.4 Traitements - Economie
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6. Lutte contre les cancers
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6.1 Observation
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6.11 Patients
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Glioblastoma Is Bad News, Period [In the Pipeline]
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Glioblastomas
are characterized by extreme genomic instability, even by the standards
of cancer cells, meaning that what appears to be a single tumor is
almost certainly a large collection of different cell types using
different mechanisms to grow and survive. That explains why no single
therapy has had much success in the field.
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He's a Fighter [The Atlantic]
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John
McCain is being urged to persevere based on strength of character, a
quintessentially American approach to thinking about health.
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John McCain’s Brain Cancer Carries a Dim Prognosis [NY Times]
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Glioblastoma
is the most aggressive type of brain tumor. It originates in the brain;
it does not spread there from another part of the body. The cause is
not known. This tumor has no relation to melanoma, the skin cancer for which Mr. McCain was treated in the past.
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6.4 Médico-éco
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6.6 Publications
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Peer review is a black box. Let’s open it up [STAT]
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Lee
and Moher propose that publishers spend 1 percent of their budgets on
research into the effectiveness of their peer review systems — a number
based on what the Human Genome Project spent to investigate the ethical,
legal, and social implications of its efforts.
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6.7 DMP, Big Data & applis
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The DeepMind debacle demands dialogue on data [Nature]
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Without
public approval, advances in how we use data will stall. That is why a
regulator's ruling against the operator of three London hospitals is
about more than mishandling records from 1.6 million patients. It is a
missed opportunity to have a conversation with the public about
appropriate uses for their data.
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6.7.1 Bioinformatique
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Unintended Consequences of Machine Learning in Medicine [JAMA]
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Comparative
studies on the effectiveness of machine learning–based decision support
systems (ML-DSS) in medicine are lacking, especially regarding the
effects on health outcomes. Moreover, the introduction of new
technologies in health care has not always been straightforward or
without unintended and adverse effects.
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