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1. Biologie
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Finally,
it should be noted that this paper isn’t just a list of reasons why
your new cancer target isn’t so great. It also provides some reasons to
keep going in the face of a common objection.
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3.1 Tabac
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A
new poll for Cancer Research UK of more than 4,300 people also revealed
that very few people want to turn back the clock and allow smoking in
enclosed public spaces. Only 12 per cent were in favour of reversing the
smokefree laws.
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Since
it came into force, the number of smokers in the UK has dropped by
almost 2 million. Other policies have played a big part in driving down
smoking rates, like tax increases on tobacco, media campaigns helping
smokers to quit, and a ban on point of sale advertising. The question
now is: what next?
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4.7 Dép., diag. & prono. - Col de l'utérus
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The
research, conducted by Cancer Research UK-funded scientists at UCL,
included survey responses from more than 3,100 eligible women aged
24-64, of whom around 790 were overdue for a smear test.
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This
incredibly useful study highlights the need for further exploration
into the reasons why some women don't go for cervical screening – what
is the exact reason women are unaware of screening, and why do they
choose not to attend?
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5. Traitements
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In
the trial, there was no difference in melanoma-specific survival
between patients who had only the lymph nodes to which the cancer was
most likely to spread, known as sentinel lymph nodes, removed and
patients who had more extensive surgery to remove additional nearby
lymph nodes.
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5.12 Immunothérapies
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This
platform will engage the global cancer immunotherapy research community
around the set-point framework in an entirely new way – through
crowdsourcing.
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5.2.1 Pharma - Partenariats
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"Many
large pharma companies are starting to realize the potential of this
approach and how it can help improve efficiencies," said Andrew Hopkins,
chief executive of privately owned Exscientia, which announced the new
tie-up with GSK.
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5.3.4 Traitements - AMM (FDA, EMA)
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The
European Commission’s approval of BESPONSA (inotuzumab ozogamicin) is
supported by results from the Phase 3 INO-VATE ALL trial, in which 326
adult patients with relapsed or refractory B-cell precursor ALL were
enrolled and which compared BESPONSA to standard of care chemotherapy.
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5.4 Traitements - Economie
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Despite
these glaring problems, current policy choices must confront the real
world we are living in. In the current situation, drug pricing and
research funding are intertwined.
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Gleevec isn’t the only cancer pill whose price has come down slowly despite losing patent protection.
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5.6 ESMO
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Reversing
the usual pattern, patients whose liver metastases had spread from
right-sided primary tumours (RSP) had a 36% better survival rate after
treatment with a combination of first-line chemotherapy and selective
internal radiation therapy (SIRT) using Y-90 resin microspheres,
compared to chemotherapy alone, according to the study.
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5.9 AACR
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Leaders
in oncology gathered to identify solutions to the challenges and
opportunities to accelerate progress toward the delivery of
patient-centered, high-value care.
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6. Lutte contre les cancers
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Changes made to better enable teamwork and decision-making.
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6.1 Observation
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The
organisation says 12,000 people who died from the disease in 2015 were
not cared for properly in the final stages. Many of these were outside
hospital and reliant on community services such as visiting nurses to
receive pain-relieving drugs.
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Men
living in the most deprived areas of England can expect to lead a
healthy life for nearly 19 years less than men living in the least
deprived. The difference for women is 19.6 years.
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6.11 Patients
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The
mission of Facebook is to connect people – and to help good things
emerge from these connections. What better forum than Facebook to bring
patients together -- and what better platform for health?
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Working
with a clinical pharmacist, the researchers identified 36 potential
interactions in 26 patients, or 17 percent. The researchers then
notified the oncologist who prescribed the anti-cancer drugs, and in all
cases, oncologists modified the patients’ therapy.
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6.12 Ethique
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Like my students, I feel a crawling discomfort at the thought of invading cyberspace to contact a patient online.
Unlike my students, however, I no longer hear it as a polar question. I
accepted a friend request from a patient’s parents, and it forever
changed my understanding of the practice of medicine.
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6.7.1 Bioinformatique
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The
consensus: It’s still early days for applying machine learning and
related techniques in healthcare, and it’s hard to foresee how these
innovations will play out.
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IBM
is ceding whatever AI leadership it purported to have to a new crop of
far more innovative startups and other AI firms willing to reinvent
themselves as the inexorable pace of innovation continues unabated – and
that’s no joke.
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6.9 Controverses
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In
June 2015, 24 Australian cancer specialists flew to Chicago to attend a
five-day conference. Drug giant Amgen funded the trip, including
registration, transfers and wining and dining. It cost almost A$270,000.
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An
underlying issue—one that potentially undermines the value of
conferences like this, and countless published papers, entire journals
in fact—is whether academic talk about evidence, randomized clinical
trials, data sharing, etc., serves patients in the real world.
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