mercredi 21 juin 2017

Onco Actu du 21 juin 2017

1. Biologie

Psst, the human genome was never completely sequenced. Some scientists say it should be [STAT]

2.5 Etiologie - Gènes

Lowering the GWAS threshold would save millions of dollars [Simply Statistics]

4.2 Dép., diag. & prono. - Génome

Study estimates breast and ovarian cancer risk linked to faulty BRCA genes [Cancer Research UK]

Women with BRCA gene mutations given clearer picture of breast and ovarian cancer risk [The Guardian]

5. Traitements

A Targeted Therapy Next in Line for Biomarker-based Cancer Drug Approval? [Cancer Research Catalyst]

Minimizing surgery for melanoma that has spread [NIH]

A Potent Tool to Treat Pancreatic Cancer May Already Be in Your Body [MIT Technology Review]

5.12 Immunothérapies

Precision Oncology: Gene Changes Predict Immunotherapy Response [NIH Director's Blog]

5.12.1 Immunothérapies - partenariats

Merck Ventures, CRUK launch new immuno-oncology spinout biotech iOnctura [FierceBiotech]

eFFECTOR Therapeutics to Collaborate with Pfizer and Merck KGAA, Darmstadt, Germany, to Evaluate a Novel Immuno-Oncology Combination in Microsatallite Stable Colorectal Cancer [eFFECTOR]

5.2 Pharma

Seattle Genetics Submits Supplemental Biologics License Application to FDA for ADCETRIS® (Brentuximab Vedotin) in Cutaneous T-Cell Lymphoma [Seattle Genetics]

5.2.3 Pharma - économie

Flagship-backed Rubius raises $120M to take off-the-shelf red blood cell cancer therapeutics into the clinic [FierceBiotech]

5.3 Traitements - FDA, EMA, NICE...

FDA to Clear Path for Drugs Aimed at Cancer-Causing Genes [Bloomberg]

5.3.4 Traitements - AMM (FDA, EMA)

FDA Approves Pembrolizumab for Tumors with Specific Genetic Features [NCI]

5.4 Traitements - Economie

Pricing pressure causes worldwide drug sales forecasts to fall for first time in 10 years [Evaluate]

Worldwide drug sale forecasts fall as pricing pressures mount [Reuters]

6. Lutte contre les cancers

Beyond the Horizon: LERU’s views on the 9th Framework Programme for Research and Innovation [LERU]

6.10 Politiques

My decade leading the WHO: dirty fights and steps toward universal coverage [STAT]

6.10.1 Politiques (USA)

At Drug Hearing, Senators Discuss Meanings Of Price And Value—And Debate Health Reform [Health Affairs Blog]

Draft Order on Drug Prices Proposes Easing Regulations [NY Times]

6.11 Patients

UK watchdog reviews travel insurance for cancer patients [Reuters]

6.3 Associations/Fondations

Cancer Research UK appoints Professor Charles Swanton as its chief clinician [Cancer Research UK]

6.9 Controverses

U.S. Supreme Court ruling threatens massive talc litigation against J&J [Reuters]