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1. Biologie
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3.1.1 Tabac - e-cigs
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5. Traitements
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New Gene Therapy Shrinks Aggressive Tumors in Mice [The Scientist]
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A
CRISPR-based gene therapy that targets cancerous fusion genes—hybrid
genes that are formed when two previously distinct genes join
together—shrinks aggressive forms of liver and prostate cancers in mice.
The approach could be developed to address the problem of drug
resistance.
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5.10 Traitements - Essais
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FDA and NIH Release Final Template for Clinical Trial Protocols [FDA Voice]
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The
final version is intended for clinical investigators who are writing
protocols for phase 2 and phase 3 NIH-funded studies requiring
investigational new drug or investigational device exemption
applications, but could also be helpful to other investigators
conducting studies of medical products that are not regulated by FDA.
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5.12 Immunothérapies
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Testing a new immunotherapy treatment for neuroblastoma [Cancer Research UK]
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This
is a phase I trial and our goal is to find out the new therapy’s
safety, and what doses we can give it to children without causing severe
side effects. Because we don’t know yet if it will be effective, we’re
testing the CAR T cells in children who have run out treatment options.
These are poorly children, whose neuroblastoma has come back and no
longer responds to chemotherapy.
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5.12.2 Immunothérapies - CAR-T
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5.2.2 Pharma - Fusions & Acquisitions
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5.2.3 Pharma - économie
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Merck's Cancer Sales Soar In White-Hot Market [Forbes]
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The
truth is Keytruda grew fast, but not quite as fast as expected, while
last week Bristol reported sales for its rival drug, Opdivo, which
reported $1.127 billion, more than $100 million above what analysts
expected.
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6. Lutte contre les cancers
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NIH to limit the amount of grant money a scientist can receive [Nature]
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The
agency will introduce a metric called the Grant Support Index (GSI),
which assigns a point value to each type of grant based on its
complexity and size. Researchers will be limited to 21 points' worth of
funding — the equivalent of three R01 grants, the most common type
awarded to individuals — at a time.
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6.10 Politiques
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6.12 Ethique
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The Complex and Multifaceted Aspects of Conflicts of Interest [JAMA]
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This
issue of JAMA contains a series of Viewpoints on the many facets of
COIs. The authors present perspectives involving multiple disciplines,
including economics, education, epidemiology, ethics, journalism,
management, medicine, pharmacy, psychology, public health, and policy.
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6.5 Médecines alternatives
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6.6 Publications
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Researchers frustrated by Italian misconduct probe [Nature]
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More
than five years ago, Italian police began investigating allegations of
research misconduct in papers by Alfredo Fusco, a prominent cancer
scientist in Naples. Researchers frustrated by the case’s slow progress
have now told Nature that there is strong evidence that dozens of papers
may contain manipulated data — and that a commercial photography studio
was called in to cut and paste images.
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