jeudi 6 avril 2017

Onco Actu du 6 avril 2017

1. Biologie

CRISPR studies muddy results of older gene research [Nature]

3.1 Tabac

FDA Warns Pfizer Clinical Investigator Over Chantix Study [RAPS]

Smoking causes one in 10 deaths worldwide, study shows [BBC News]

Smoking causes one in ten deaths globally, major new study reveals [The Guardian]

4.1 Dép., diag. & prono. - Prostate

Guys: you don't need a PSA test for prostate cancer [Genomics, Medicine, and Pseudoscience]

4.13 Dép., diag. & prono. - Peau

Pivotal Study Results for Myriad's myPath® Melanoma Test Highlighted In Two Additional Scientific Publications [Myriad]

5. Traitements

Taking Shortcuts In Drug Testing Can Put Patients At Risk [NPR]

5.12 Immunothérapies

Cancer immunotherapy: more reason for concern? [HealthNewsReview]

5.12.2 Immunothérapies - CAR-T

Novartis Keeps 'JULIET' Study Results Close as Investors and Rival Kite Pharma Wait [The Street]

5.12.5 Immunothérapies - Pharma

Will AACR news give BMS cancer linchpin Opdivo a boost? That depends, analysts say [FiercePharma]

5.3 Traitements - FDA, EMA, NICE...

Regulatory Review of New Therapeutic Agents — FDA versus EMA, 2011–2015 [NEJM]

NCCN Statement on FDA Leadership and Vision for the Future [National Comprehensive Cancer Network]

FDA Nominee Scott Gottlieb To Anti-Vaccine Crowd: Get Over It [Xconomy]

FDA nominee says agency must strike right balance between risk, regulation [STAT]

Trump nominee to lead FDA questioned on ties to pharmacy industry [Reuters]

F.D.A. Nominee Deflects Criticism About Ties to Drugmakers at Hearing [NY Times]

With Brexit underway, EU drug agency prepares to leave London [Reuters]

Gottlieb At the FDA [In the Pipeline]

5.9.3 AACR - mélanome

Interim Phase 2 Data Demonstrate Robust Response Rate with Indoximod in Combination with Keytruda® (pembrolizumab) for Patients with Advanced Melanoma at AACR Plenary [NewLink Genetics]

5.9.4 AACR - poumon

Immunomedics says IMMU-132 hits targets in small cell lung cancer [FierceBiotech]

5.9.5 AACR - CAR-T

Immunotherapy for ovarian cancer shows promise in mouse model, but hurdles remain [Fred Hutch]

5.9.6 AACR - prostate

New Form of Therapeutic Shows Efficacy Against Castration-resistant Prostate Cancer in Preclinical Studies [AACR]

5.9.7 AACR - divers

AACR: 4 Ways surgery will augment molecular medicine to fight cancer [Colorado Cancer Blogs]

Radiation may promote cancer risk by changing selective pressures [Colorado Cancer Blogs]

Cancer Burden May Be Changing for People Living With HIV [AACR]

6.10.1 Politiques (USA)

How the GOP Could Use Science’s Reform Movement Against It [The Atlantic]

6.12 Ethique

Star pediatric oncologist committed misconduct, ethical violations: reports [Retraction Watch]

Some Thoughts on the New Common Rule for Human Subjects Research [Genomics Law Report]

6.6 Publications

Most citations to retracted papers don’t note they’re problematic, authors say [Retraction Watch]