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2. Etiologie
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2.5 Etiologie - Gènes
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Random Mutations Play Major Role in Cancer [NIH Director's Blog]
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As
further evidence for the importance of random copying errors in cancer,
the researchers evaluated the incidence, or number of cases, of 17
cancer types from 69 countries around the globe in data collected by the
International Agency for Research on Cancer in France. The researchers
asked whether differences in the number of times stem cells divide could
help to explain differences in the incidence of some common cancers.
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3.3 Prévention - Vaccins
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4. Dépistage, diagnostic et pronostic
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4.7 Dép., diag. & prono. - Col de l'utérus
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5.10 Traitements - Essais
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5.12.2 Immunothérapies - CAR-T
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Making CAR T-Cell Therapy Safer [The Scientist]
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Following
a spate of patient deaths in clinical trials testing modified T cells
for the treatment of cancer, researchers work to reduce the treatment’s
toxicity without sacrificing efficacy.
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5.12.5 Immunothérapies - Pharma
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5.2 Pharma
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5.2.1 Pharma - Partenariats
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5.3 Traitements - FDA, EMA, NICE...
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Conflicts surround Trump's FDA pick [CNN]
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"Certainly,
there's been a loud chorus of support from pharma and medical device
companies," Carome observed. "They look forward to him being
commissioner, as they believe he'll promote their interests."
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5.4 Traitements - Economie
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NICE turns down Shire's pancreatic cancer treatment [Pharmafile]
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The
combination of Onivyde, 5-FU and LV has shown to generate an overall
median survival rate of 6.1 months compared to the 4.2 months provided
by 5-FU and LV alone. However, NICE judged that, when compared to the
clinical standard of oxaliplatin plus 5-FU and LV, Onivyde did not
present any significant benefits.
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5.5 ASCO
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5.9.3 AACR - mélanome
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New Immunotherapy Combination Shows Promise for Patients With Advanced Melanoma [AACR]
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Curti
and colleagues are enrolling up to 70 patients with advanced melanoma
in the melanoma intratumoral Cavatak and ipilimumab (MITCI) clinical
trial. Patients who have and who have not received immune checkpoint
inhibitors are eligible for the trial. CVA21 is injected directly into
melanoma lesions, while ipilimumab is infused intravenously.
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5.9.4 AACR - poumon
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5.9.5 AACR - CAR-T
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5.9.7 AACR - divers
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5.9.9 AACR - immunothérapies
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6. Lutte contre les cancers
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6.10 Politiques
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6.10.1 Politiques (USA)
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What Trump gets wrong about drug companies [STAT]
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Clinical
trials should still be an essential step of the FDA review process;
patients need to know a drug is both safe and effective. But today we
have the capability of leveraging big data within health care systems to
discern answers better, faster, and cheaper.
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6.5 Médecines alternatives
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6.6 Publications
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