mardi 18 avril 2017

Onco Actu du 18 avril 2017

2.11 Etiologie - Alimentation

Pesticide residues in food: risk to consumers remains low [EFSA]

2.6 Etiologie - Environnement

New study on Monsanto weedkiller to feed into crucial EU vote [Reuters]

3.3 Prévention - Vaccins

Teenage boys could be given HPV jabs to prevent cancer [The Telegraph]

4. Dépistage, diagnostic et pronostic

Chewing Gum To Detect Cancer: Reporting The Hype, Diminishing The Facts [Dr. Len]

4.1 Dép., diag. & prono. - Prostate

Should you get screened for prostate cancer? We break down the latest advice [STAT]

The federal panel that opposed prostate cancer screening just changed its mind [Washington Post]

Is PSA now “OK”? What the task force really said about the evidence on prostate cancer screening [HealthNewsReview]

The Task Force Shift on PSA: It Really IS A Big Deal [Dr. Len]

The new recommendations for prostate cancer screenings are a bad deal [STAT]

Panel Re-Opens the Door for PSA Screening in Men 55-69 [ACS]

Benefits of PSA test to screen for prostate cancer are roughly equal to its harms, expert panel says [LA Times]

Prostate Cancer Screening Draft Recommendations [USPTF]

New Official Prostate Cancer Screening Guidelines Announced: Too Little, Too Late? [Forbes]

Discuss Prostate Screening With Your Doctor, Experts Now Say [NY Times]

4.10 Dép., diag. & prono. - FDA, EMA, NICE,...

‘Organs-on-Chips’ Technology: FDA Testing Groundbreaking Science [FDA]

4.12 Biopsies liquides

ctDNA technology in lung cancer: personalised healthcare in action [PHG Foundation]

Can A Simple Blood Test Really Spot Cancer Early? Don’t Bet On It Yet, Scientists Say. [BuzzFeed]

4.9 Dép., diag. & prono. - Sein

Genetic tests for breast cancer underused, misunderstood, say researchers [Stanford Medicine]

Are Oncologists Jumping the Gun with the 21-Gene Assay? [Colorado Cancer Blogs]

5. Traitements

Nanoparticles reprogram immune cells to fight cancer [Fred Hutch]

Studies Identify Potential Treatment Strategies for Pediatric DIPG Brain Tumors [NCI]

5.12 Immunothérapies

Study suggests why an immunotherapy drug works in some melanoma patients but not in others

Personalized tumor vaccines keep cancer in check [Science]

5.12.1 Immunothérapies - partenariats

Bristol-Myers Squibb and Apexigen, Inc. Announce Clinical Collaboration to Evaluate Opdivo (nivolumab) in Combination with APX005M in Advanced Solid Tumors [BMS]

5.12.2 Immunothérapies - CAR-T

Novartis CAR-T cell therapy CTL019 receives FDA Breakthrough Therapy designation for treatment of adult patients with r/r DLBCL [Novartis]

Novartis advances with push on cancer and liver disease [Reuters]

5.12.3 Immunothérapies-combinaisons

Blocking growth of tumour blood vessels could boost immunotherapy [Cancer Research UK]

Glioblastoma Patients May Benefit from a Vaccine-Chemotherapy Combination [AACR]

5.12.5 Immunothérapies - Pharma

Scoop: Juno recruits Sunil Agarwal as R&D chief, opening a Bay Area facility in research revamp [EndPoints]

5.2 Pharma

Hanmi hit over failure to disclose olmutinib cancer trial side effect [FierceBiotech]

OncoMed’s bad, no good, disastrous month continues as another PhII flops, PhIb trial is shuttered [EndPoints]

OncoMed's lung cancer drug fails mid-stage study, shares tumble [Reuters]

5.2.3 Pharma - économie

Cancer Drugmaker G1 Therapeutics Makes IPO Pitch To Wall Street [Xconomy]

Nine blockbuster drugs to watch are making their debut, aiming at a $16B prize in 2021 [EndPoints]

5.3 Traitements - FDA, EMA, NICE...

EMA Updates Guidance on Clinical Data Publication Policy [RAPS]

The UK isn’t giving up on keeping the European Medicines Agency’s HQ in London without a fight [EndPoints]

FDA Officials Question Lack of New Cancer Drugs Developed in Combination With Radiation [RAPS]

5.3.4 Traitements - AMM (FDA, EMA)

FDA Approves Pembrolizumab for Hodgkin Lymphoma [NCI]

FDA Approves Niraparib as Maintenance Therapy for Recurrent Ovarian Cancer [NCI]

Roche's Tecentriq wins FDA approval for treating advanced bladder cancer [Reuters]

5.4 Traitements - Economie

NICE says head and neck cancer drug is not cost effective [NICE]

Immunotherapy drug too costly for head and neck cancer [Cancer Research UK]

5.9 AACR

Blood tests, microbes, immunotherapy and more: AACR 2017’s hottest topics [Cancer Research UK]

6. Lutte contre les cancers

NIH program strives to turn more lab discoveries into real-world treatments [STAT]

When I use a word . . . Translational research—a new operational model [BMJ Blogs]

With this new system, scientists never have to write a grant application again [Science]

6.1 Observation

Revealed: 100,000 wait more than two weeks to see cancer specialist [The Guardian]

Cancer Occurrence among African-born Blacks Differs Substantially from Blacks Born in the U.S. [ACS]

Recorded childhood cancers rise by 13% worldwide, study finds [The Guardian]

6.10.1 Politiques (USA)

The cruel sham that is right-to-try raises its ugly head at the federal level again [Science-Based Medicine]

6.11 Patients

At the End of Life, a Way to Go Gentle [NY Times]

6.12 Ethique

Why do researchers commit misconduct? A new preprint offers some clues [Retraction Watch]

Fostering Integrity in Research [National Academies Press]

U.S. panel sounds alarm on “detrimental” research practices, calls for new body to help tackle misconduct [Retraction Watch]

6.3 Associations/Fondations

Drugmakers Help Turn Patients With Rare Diseases Into D.C. Lobbyists [KHN]

6.4 Médico-éco

How Much Does Cancer Cost? New Report Examines Expected Patient Costs for Common Cancer Diagnoses [Cancer Action Network]

6.6 Publications

Fired Pfizer cancer researcher loses final two of five papers pegged for retraction [Retraction Watch]

The ORCID Open Letter: One Year On [ORCID]

6.7 DMP, Big Data & applis

One of Google's most embarrassing flops is turning into a real business [CNBC]

6.9 Controverses

‘It will help us with our product’: Emails show how a billionaire’s philanthropy boosted his business [STAT]

Interview with Professor Doug Altman [MiRoR]