Onco Actu du 8 mars 2017

	1. Biologie
‘Google Earth’ for tumours could change cancer diagnostics and drug testing forever [Cancer Research UK] Bunch’s international team, which received £16 million through our Grand Challenge award last month, think they now have the technology to make complete maps of tumours that are so desperately needed.
	3.1 Tabac
Smoking numbers hit new low as Britons turn to vaping to help quit cigarettes [The Guardian] The number of smokers in Britain has reached its lowest point since records began in 1974, according to new data, while more than a million people say they are using e-cigarettes to help them quit smoking.
	3.8 Prévention - Alimentation
Mediterranean diet linked to lower risk of one type of breast cancer [NHS Choices] The typical weakness of this type of study is that many factors are likely to contribute to risk, and it's very difficult to be sure the factor in question – in this case, eating a Mediterranean diet – is wholly responsible for the differences seen.
	4.10 Dép., diag. & prono. - Poumon
Noninvasive strategies for lung cancer testing [NIH] Researchers discovered that the activity of a number of genes are altered in the nasal cells of patients with lung cancer who have been smokers.
Gene activity in the nose may signal lung cancer [Reuters] Researchers found that distinctive changes in gene activity in the nasal epithelium of lung cancer patients closely parallel the changes seen in lung epithelium and can distinguish between benign lung disease and cancer.
	4.11 Dép., diag. & prono. - Ovaire
Are Routine Pelvic Exams A Must? Evidence Is Lacking, Task Force Says [NPR] The exam shouldn't be used as a screening tool, the ACP said, because there's no good evidence it picks up ovarian cancer, and the downside of its use among healthy women is significant — false positives can lead to needless anxiety for the patient and additional testing or even surgery that's more invasive and costly.
U.S. doctors not sure all women need pelvic exams [Reuters] With ovarian cancer, for example, a few studies found false positive results in 1.2 percent to 8.6 percent of cases. Between 5 percent and 36 percent of women with abnormal results suggesting cancer got surgery. Some studies also found “false negative” results that miss malignancies.
	5.12 Immunothérapies
Few people actually benefit from ‘breakthrough’ cancer immunotherapy [STAT] When immunotherapy works, the result is terrific, even life-changing. Today, though, only a tiny minority of patients expected to die from cancer will benefit from immunotherapy. As is often the case, hype sadly exceeds evidence, creating misunderstandings between patients and their doctors.
	6.1 Observation
Cancer Rates Dropped During The Recession. That’s Not Necessarily A Good Thing. [KHN] If people did delay getting screened for early-stage cancers during the recession, “might we then start seeing an uptick of late-stage cancers?” wondered Scarlett Lin Gomez, the study’s lead author and a researcher with the Cancer Prevention Institute of California.
Numbers missing two-month cancer treatment target window doubles amid warnings A&E crisis is sucking away resources [The Telegraph] One in six people diagnosed with the disease began treatment after the aimed-for 62 days in 2016, according to the charity, making it the third consecutive year in which the health service failed to keep pace with rising demand.
	6.10.1 Politiques (USA)
Trump tweets a new vow to spur competition in the pharma biz, slashing prices [EndPoints] This latest tweet is also long on promise and short on details. And it’s the details — like Trump’s pick for FDA commissioner — which people in the industry want to see now.
	6.5 Médecines alternatives
Here are the alternative therapies offered by top hospitals [STAT] There’s little or no scientific evidence behind alternative therapies like energy healing, acupuncture, and homeopathy. Yet many of the most prestigious hospitals in the US — which are dedicated to the pursuit of evidence-based medicine — offer such therapies nonetheless.
	6.6 Publications
Science journalism can be evidence-based, compelling — and wrong [Nature] A ranking of the best science-news outlets misjudges the relationship between research and reporting.
	6.7 DMP, Big Data & applis
CureMatch Uses Analytics to Rank Best Options for Cancer Treatment [Xconomy] The company says its software combs through millions of possible drug combinations, comparing a patient’s genetic profile with data from clinical trials, publications, and drug interactions to identify optimal treatment regimens.