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3.1 Tabac
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The
research looked at 126 countries, all but 10 of which signed up to the
treaty. Smoking rates fell by an average of more than 2.5% in the
countries that adopted the framework, a steeper fall than in the other
10 nations.
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3.4 Chimioprévention
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NICE
recommends anastrozole is offered for 5 years to postmenopausal women
at high or moderate risk of breast cancer unless they have severe
osteoporosis. And clinicians should consider offering it to women at
moderate risk of breast cancer.
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The
cost regulator recommends that doctors prescribe either tamoxifen,
raloxifene and now anastrozole to potentially hundreds of thousands of
'healthy' women who have no personal history of breast cancer but have a
higher risk of developing it.
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5.2 Pharma
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Working
with mice with an aggressive form of CML, Novartis scientists tested a
carefully designed combination of two molecules—a drug already approved
for use in cancer patients, plus an investigational one called ABL001.
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5.2.1 Pharma - Partenariats
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By
analyzing genetic variations and health in 500,000 middle-aged and
older Britons, the partners said on Thursday they hoped to identify
promising leads for new medicines.
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5.2.3 Pharma - économie
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The
biotech, which has not been overly communicative (its last formal PR
was back in 2015), is working on a first-in-class anti-FGFR3 (fibroblast
growth factor receptor 3) mAb in a phase 1/2 study in patients with
metastatic bladder cancer, or metastatic urothelial carcinoma (mUC), who
have relapsed or are refractory to platinum therapy.
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With
the new capital, BioClin says it will test its drug in patients who
have metastatic bladder cancer or metastatic urothelial carcinoma and
have either relapsed or failed to respond to first-line cancer
treatments.
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BioClin
is in a Phase Ib/II study of its FGFR3 receptor drug B-701 combined
with docetaxel for Stage IV bladder cancer. It’s also prepping a similar
stage trial of the same drug combined with Roche’s checkpoint Tecentriq
(atezolizumab).
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Overall,
shifting the focus from individual drug pricing towards
pharmacoeconomic value is in the best interest of all stakeholders.
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5.3 Traitements - FDA, EMA, NICE...
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EMA to set up technical group in the context of the publication of clinical data.
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5.4 Traitements - Economie
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Budget
impact is essentially the price per patient multiplied by the number of
patients treated. Yet the prevalence of someone’s condition should not
determine their access to treatment.
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6. Lutte contre les cancers
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In
“State of Cancer Care in America: 2017,” ASCO Lays Out Vision for
Cancer Care Delivery System to Address Growing Patient Population, and
Access, Affordability Challenges.
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6.1 Observation
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These
uncertainties aside, this study provides reassuring news for older
women, who may wonder whether the oral contraception they used in their
younger years has increased the risk of getting cancer. There's no
evidence from this study of an increase in cancer risk – and the reverse
may be true for certain types of cancer.
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6.10.1 Politiques (USA)
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The NIH pursues research that only the government can take on.
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Funding
is like water in the desert, life will bloom wherever there is water,
and will wilt and die without it. A sudden and dramatic cut in funding,
such as an 18% decrease for the NIH, is a disaster for our biomedical
research infrastructure.
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6.12 Ethique
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Some
physicians, ethicists, and regulatory officials say the laws could harm
more patients than they help — but many are reluctant to publicly
oppose the laws for fear of being seen as opposing any one patient’s
quest to save his or her life.
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6.2 Implants mammaires
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A
study published earlier this year estimated the lifetime prevalence of
ALCL in people with textured implants is 33 per 1 million persons.
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On
average, the cancer occurs eight years after a woman gets an implant,
according to the American Society of Plastic Surgeons. It noted only
about 10 new cases are reported worldwide each year.
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6.5 Médecines alternatives
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Basically,
Ibrisevic died because she trusted a quack instead of conventional
medicine. Yes, she had probably a 50% chance of dying anyway if she had
accepted conventional treatment before it was too late, but that’s a 50%
chance she didn’t have once she believed Gonzalez’s claims and acted
upon them.
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6.6 Publications
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An
ORCID record contains only metadata, so, for example, for a journal
article, ORCID stores the title, author list, date, and DOI, but not the
article itself. We also do not collect or store sensitive information,
such as a user's address, tax ID, or financial or medical information.
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The
world of scientific publishing is definitely more complex than can be
expressed with a two-digit number. In the end, we still need to read,
discuss, and try to understand papers before judging them.
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