Onco Actu du 7 février 2017

	3. Prévention
Study Links Intentional Weight Loss to Decreased Risk of Endometrial Cancer in Postmenopausal Women [ASCO] These findings, which draw from the Women’s Health Initiative (WHI) study data, were published online today in the Journal of Clinical Oncology.
	3.1.1 Tabac - e-cigs
E-cigarettes safer than smoking says long-term study [Cancer Research UK] E-cigarettes are less toxic and safer to use compared to conventional cigarettes, according to research published in Annals of Internal Medicine today (Monday).
New study comes the closest yet to proving that e-cigarettes aren’t as dangerous as smoking [Cancer Research UK] The study included a group of e-cigarette users, who had been using them for an average of around 17 months, and measured the levels of nicotine and 26 potentially harmful chemicals in their body, by looking at samples of their urine and saliva.
Many teens use e-cigarettes for 'dripping' liquid nicotine [Reuters] While e-cigarettes may contain fewer toxicants than traditional cigarettes, they do contain chemicals like propylene glycol and glycerin, “which when heated at high temperatures like with ‘dripping’ can produce high levels of carcinogenic compounds like aldehydes".
Study of cancer-causing toxins finds e-cigarettes much safer than smoking [Reuters] Researchers found that people who switched from smoking regular cigarettes to e-cigarettes or nicotine replacement therapy (NRT) such as gum or patches for at least six months had much lower levels of toxins in their saliva and urine than those who continued to smoke.
	4.5 Dép., diag. & prono. - Colorectal
Clinical Practice Guideline Focuses on Molecular Biomarker Testing for Patients with Colorectal Cancer [ASCO] This pivotal guideline addresses testing a wide range of molecular biomarkers in patients with early and advanced colorectal cancer.
	5. Traitements
Old drug may provide new hope to melanoma patients [Weill Cornell Medicine] Researchers from Memorial Sloan Kettering Cancer Center have filed a request with the FDA to bring back the drug phenformin as a therapeutic for melanoma and are teaming up with researchers from Weill Cornell Medicine and Massachusetts General Hospital to conduct the first clinical trials.
Low-dose chemotherapy protocol relies on normalization of tumor blood supply [Mass. General Hospital] "The most important conclusion is that better treatment outcome depends on the improvement of a tumor’s blood supply through vascular normalization – something that can be measured throughout a course of treatment through MR or ultra-CT imaging to allow patient-specific dosage and scheduling.”
Lasers help doctors remove brain cancer [BBC News] The technique, called SRS microscopy, has been tried on more than 360 patients at the University of Michigan Medical School and Harvard University.
	5.10 Traitements - Essais
NCTN/NCORP Data Archive: Expanding Access to Clinical Trial Data [NCI] This new centralized database is a repository of patient-level data from phase III clinical trials conducted by the trials groups that are part of NCI’s National Clinical Trials Network (NCTN), NCI’s Community Oncology Research Program (NCORP), and the National Cancer Institute of Canada-Clinical Trials Group.
	5.12 Immunothérapies
Use of Nivolumab Expanded to Sixth Cancer Type [Cancer Research Catalyst] Given that the approval of nivolumab centers on response data, rather than overall survival, BMS is required by the FDA to conduct additional studies to confirm that the immunotherapeutic improves survival for patients with urothelial carcinoma.
	5.12.2 Immunothérapies - CAR-T
Cellectis preps for groundbreaking US trials for an off-the-shelf CAR-T therapy [EndPoints] The plan now is to get started in the next few months, wrap up their early-stage work in early 2018 and then launch what they hope will be a registrational Phase II trial in mid-2018 — provided the FDA signs off.
Cellectis gets U.S. go-ahead to test 'off-the-shelf' cell therapy [Reuters] It marks the first time that U.S. regulators have approved clinical testing of an allogeneic, or "off-the-shelf", gene-edited CAR T cell treatment.
	5.4 Traitements - Economie
Dear President Trump: Your big idea on drug pricing is half-baked [STAT] The US is unlikely to be able to use trade agreements as leverage to raise prices abroad.
Big Pharma’s Offer to Trump: Discounts When Drugs Don’t Work [Bloomberg] While reimbursing part of the cost for a treatment that doesn’t perform well sounds like a sensible solution, the concept is hard to execute.
	6.1 Observation
Doubly devastated: Poor women more likely to lose their jobs during cancer treatment [STAT] The research team led by Dr. Victoria Blinder, a medical oncologist at Memorial Sloan Kettering Cancer Center, followed 267 women through breast cancer treatment in New York City.
Childhood cancer treatments tied to sex lives years later [Reuters] For the new study, she and her colleagues surveyed 144 survivors of childhood cancer and 144 people with similar background who didn't have cancer during childhood. Participants were ages 20 to 40 when they answered questionnaires about their psychosexual development, sexual satisfaction and satisfaction with relationship status.
	6.6 Publications
Cancer researcher logs 6 retractions, bringing total to 10 [Retraction Watch] Three of the papers had already been flagged by the journal with expressions of concern. The last author on all the papers is Anil Jaiswal, a professor in the pharmacology department. He has issued four previous retractions.
What the Acquisition of Meta Means for Scholarly Publishers [The Scholarly Kitchen] The acquisition of Meta by the Chan Zuckerberg Initiative (CZI) promises to transform scientific investigation. As a byproduct of this, it will likely transform scientific publishing as well.