Onco Actu du 15 février 2017

	1. Biologie
High-res biomolecule imaging [MIT News] A new method developed by researchers at MIT could lead to a way of producing high-resolution images of individual biomolecules without requiring crystallization, and it could even allow zoomed-in imaging of specific sites within the molecules.
The genomics of cervical cancer [NIH] To gain new insights into cervical cancer, researchers with The Cancer Genome Atlas (TCGA) Research Network analyzed the genomes of 178 primary cervical cancers.
	2.7 Etiologie - Obésité
Lifetime weight gain linked to oesophageal and stomach cancers [Cancer Research UK] This study highlights how weight gain over the course of our lives can increase the risk of developing these two cancer types, both of which have extremely poor survival.
Weight gain over adult life linked to greater digestive cancer risk, says study [The Guardian] People who are overweight in their 20s and then become obese later in life may be three times more likely to develop oesophageal or stomach cancer, according to new research.
	3.4 Chimioprévention
GPs 'failing to prescribe tamoxifen to prevent breast cancer' [NHS Choices] This study does have some limitations, however. A small proportion of those initially contacted actually completed the survey. Respondents might not represent the demographics of GPs across the UK, and the results may not be generalisable.
	4.12 Biopsies liquides
Europe Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market Report 2017 [ReportsnReports] This report studies sales (consumption) of Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) in Europe market, especially in Germany, France, UK, Russia, Italy, Spain and Benelux, focuses on top players in these countries, with sales, price, revenue and market share for each player.
	4.9 Dép., diag. & prono. - Sein
Stories lament ‘delay’ in getting a mammogram after a false-positive scan, but is that such a bad thing? [HealthNewsReview] The U.S. Preventive Services Task Force (USPSTF) recommends that women start mammograms at the age of 50 and get them every other year (every 24 months) until they reach 75. That’s about the same interval (25 months) that the CBS story frames as a “delay” in getting a mammogram. So maybe that’s not a “delay” at all.
	5. Traitements
Radiation therapy continues to be gold standard for palliative care of painful bone metastases [ASTRO] Updated ASTRO guideline upholds standard of care and emphasizes safety and efficacy of radiation treatment.
	5.12.5 Immunothérapies - Pharma
Celgene co-founder Sol Barer bags a Johns Hopkins immuno-oncology spinout in buyout [EndPoints] A few weeks ago, Johns Hopkins Professor Jonathan Schneck published new research showing how the biomimetic nano beads he had created in the lab could work with a checkpoint inhibitor in fighting cancer. That work Schneck did is held by a Johns Hopkins biotech spinout he created called NexImmune, which Celgene co-founder and serial biotech startup master Sol Barer just acquired.
	5.2 Pharma
Amgen Submits Supplemental Biologics License Application For BLINCYTO® (Blinatumomab) In Relapsed Or Refractory B-Cell Precursor Acute Lymphoblastic Leukemia [Amgen] Application Includes Overall Survival Data From Phase 3 TOWER Study to Support Conversion From Accelerated Approval to Full Approval.
	6. Lutte contre les cancers
Cooling Cap May Limit Chemo Hair Loss In Women With Breast Cancer [NPR] Hershman cautions that more study is needed to determine whether there is psychological benefit in using the caps to prevent hair loss. And the cost and who will pay for the treatment are also issues, she says.
Cold Caps May Prevent Hair Loss From Chemotherapy: What We Know–And What We Don’t [Dr Len] So here’s we are so far: Cooling the scalp appears to prevent hair loss in at least half and maybe more of the women receiving chemotherapy as part of their treatment for breast cancer. But overall there’s not much effect on quality of life.
Scalp Cooling Helps Prevent Hair Loss in Chemo [NY Times] The continual cooling constricts blood vessels in the scalp, reducing blood flow to the area, and slows the metabolism of hair follicle cells, limiting the effects of chemotherapy on hair.
Cooling caps help women keep hair during breast cancer chemo [Reuters] Cooling caps are relatively new to the United States but are established in other countries, according to one of the new studies published in JAMA.
	6.10.1 Politiques (USA)
Pharma industry shuns Trump push for radical shift at FDA [Reuters] "People often argue that the FDA is too restrictive," said Roger Perlmutter, head of research and development at Merck & Co Inc. "We have the sense that the balance is pretty right ... you have to have a well-characterized risk/benefit profile."
	6.11 Patients
A dying patient teaches a young doctor about the limits of medicine [STAT] Yet standing there in front of Janice and her family, everything I knew about her cancer stopped me from offering them any possibility for further curative treatment. That stood in stark contrast to what I thought was my principal task as a physician: making things better again.
	6.6 Publications
Science journals permit open-access publishing for Gates Foundation scholars [Nature] If research funders demand open-access publishing, will subscription journals acquiesce? An announcement today by the publisher of Science suggests they will — as long as that funder is as influential as the Bill & Melinda Gates Foundation.
	6.9 Controverses
The Soon-Shiong Hype Machine [In the Pipeline] This is a crazily hard field to make progress in, and claiming that you’re just making these incredible strides every day of the week is not doing anyone any good – well, unless your name is Patrick Soon-Shiong.