Onco Actu du 27 janvier 2017

	1. Biologie
Trying to Tango with More Than 2: Extra Centrosomes Promote Tumor Formation in Mice [Johns Hopkins] Improper chromosome separation sets the stage for cancer.
	3.6 Prévention - Activité physique
Incorporating Weight Management and Physical Activity Throughout the Cancer Care Continuum: A National Cancer Policy Forum Workshop [National Academies] Workshop sessions and discussions will examine the evidence base on obesity, physical activity, weight management, and health outcomes in cancer survivors, as well as the effectiveness of interventions for promoting physical activity and weight management in cancer survivors.
	5. Traitements
Curbing inflammation after radiation therapy slows pancreatic tumor growth in mice [FierceBiotech] The team plans to look into tumor-associated inflammatory cells and radiation therapy in human patients. They will also try to unravel why radiation therapy provokes an antitumor response in a patient’s T cells in other cancers but not in pancreatic cancer.
	5.10 Traitements - Essais
Are Phase I Trials Ethical? [In the Pipeline] The only cohort that can be considered to derive at least a modicum of medical benefit from volunteering in a phase 1 trial consists of patients who have the condition for which the drug is being developed as a treatment. They should be the only persons who are asked to volunteer for a phase 1 trial.
	5.12.2 Immunothérapies - CAR-T
Researchers publish paper on first uses of Cellectis’ CAR-T [FierceBiotech] If Cellectis can show these issues don’t outweigh the benefits of UCART19, it and its partners Pfizer and Servier could upend the CAR-T field.
	5.14 ECCO
Twice-daily radiation therapy cuts deaths from head and neck cancer [ECCO] Dr Petit cautioned that she has not yet studied the side effects experienced by patients, either during treatment or in the longer term, and that more research is needed to examine this and to confirm the results.
	5.2 Pharma
Bristol-Myers Goes From Hunter to Target [Bloomberg] After a $50 billion plunge in market cap, Bristol-Myers is looking less like a potential mega-acquirer and more like an increasingly vulnerable mega-target.
	5.3.4 Traitements - AMM (FDA, EMA)
Ibrutinib Use Expanded to Additional Type of Non-Hodgkin Lymphoma [Cancer Research Catalyst] Given that the approval centered on response data, rather than overall survival, the companies jointly developing ibrutinib, Janssen Biotech Inc. and Pharmacyclics LLC, are required by the FDA to conduct a study to confirm that the drug improves survival for patients.
	5.4 Traitements - Economie
CLL patients get routine NHS access to Janssen’s Imbruvica [Pharma Times] The National Institute for Health and Care Excellence has approved funding the drug for use in patients who have had at least one prior therapy or who have a 17p deletion or TP53 mutation, and in whom chemo-immunotherapy is unsuitable.
	5.5 ASCO
2017 Symposium to Feature New Insights for Patient Care After Cancer Treatment [ASCO] Five studies highlighting notable research on survivorship care will be presented at the 2017 Cancer Survivorship Symposium, taking place January 27-28 at the Manchester Grand Hyatt in San Diego.
	6. Lutte contre les cancers
Anxiety and depression linked to increased cancer death risk [NHS Choices] We don't know from the study whether mental distress is a cause of cancer, or of cancer mortality. It could be a reflection of another confounding factor – for example, people with poor mental health may have a poor diet, and diet is linked to cancer. Or mental distress could be a result of poor physical health, which itself could have increased the chances of death from cancer.
Treat older prostate cancer patients according to fitness, not age: guidelines [Reuters] To update the Society’s 2014 guidelines for treating elderly prostate cancer patients, the task force reviewed articles published between 2013 and 2016 on treatment of prostate cancer patients over age 70 and each member proposed guideline changes. The results represent their consensus.
	6.1 Observation
Surveillance for Cancer Incidence and Mortality — United States, 2013 [CDC] This report provides, in tabular and graphic form, official federal statistics on cancer incidence and mortality for 2013 and trends for 1999–2013 as reported by CDC and the National Cancer Institute (NCI).
Cervical surgery for pre-cancer tied to preemies and small babies [Reuters] In the study, researchers examined data on pregnancy outcomes for 4,307 women who didn’t have cervical procedures and compared them to 322 women who had surgery to remove precancerous tissue and another 847 women who had cervical biopsies to investigate abnormalities.
	6.5 Médecines alternatives
Fake medicine endangers another cancer patient’s life [Respectful Insolence] In this case, the woman’s name is Sarah Valentine; the cancer is breast cancer; and the story appeared in the Mirror and entitled Mum-of-four battling breast cancer turns down traditional NHS treatment in favour of vegan diet: Sarah Valentine, whose youngest child is aged just one, says she is “100 per cent sure” her breast cancer is “emotional”.