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1. Biologie
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1.1 Biologie - Gènes
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2.11 Etiologie - Alimentation
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3.1 Tabac
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3.1.1 Tabac - e-cigs
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4.2 Dép., diag. & prono. - Génome
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5. Traitements
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New insights into why breast cancer drugs fail for some women [NHS Choices]
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One
of the researchers, Dr Luca Magnani, commented: "In many cases when an
aromatase inhibitor stops working in a patient, doctors will try another
type of aromatase inhibitor. However, our research suggests that if the
patient's cancer has started to make their own aromatase, this second
drug would be useless. This is why we need a test to identify these
patients."
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5.10 Traitements - Essais
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5.12 Immunothérapies
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Opdivo Making Strides in Advanced Hepatocellular Carcinoma [OBR Blog]
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The
data that are unfolding continue to support a potential future scenario
in which Opdivo emerges triumphant as a new leader in HCC management,
potentially unseating Nexavar in the front-line and bringing a more
effective and tolerable treatment to a very ill patient population
greatly in need of some hope.
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5.12.5 Immunothérapies - Pharma
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5.2 Pharma
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5.3 Traitements - FDA, EMA, NICE...
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I Do Hate To Tell You This, But. . . [In the Pipeline]
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So,
to sum up, most investigational drugs don’t work. “Freeing up” the
system in order to give them to more people will merely allow more
people (and more insurance companies) to pay for drug candidates that
don’t do anything, or actually make people worse.
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Keep Politics Out Of Science, Says Departing FDA Chief [Forbes]
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“The
most recent empirical data that we have at the FDA is that
approximately 92% of drugs that go into human testing don’t make it to
market because they have unacceptable toxicity, they actually don’t work
for the intended purpose, or they can’t be manufactured at scale
safely,” Califf says.
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6.1 Observation
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The risk of death from cancer may depend on where you live [Reuters]
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Cancer
fatalities now account for about 192 deaths for every 100,000 people in
the U.S., down from 240 per 100,000 at the start of the study period.
But in some parts of the country where poverty, obesity and smoking are
more common, rates of death from cancer are going up.
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6.10 Politiques
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We must urgently clarify data-sharing rules [Nature]
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Another
important consideration is that the EU is planning to spend €6.7
billion (US$7.2 billion) on a European Open Science Cloud initiative,
which means that data sharing has to work across borders. If it does
not, the cloud will be very cloudy indeed.
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6.11 Patients
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6.5 Médecines alternatives
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6.6 Publications
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6.7 DMP, Big Data & applis
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