vendredi 13 janvier 2017

Onco Actu du 13 janvier 2017


1. Biologie

Five big mysteries about CRISPR’s origins [Nature]

Unexpected mutations hint at tumor cells’ histories [Broad Institute]

Researchers turn leukemia cells into embryonic-like cells [Stanford Medicine]


2.6 Etiologie - Environnement

Exclusive: U.S. congressional committee demands answers on WHO cancer agency [Reuters]

3. Prévention

Curcumin Will Waste Your Time [In the Pipeline]

4. Dépistage, diagnostic et pronostic

Welsh government to introduce improved screening tests for cervical and bowel cancers [Cancer Research UK]

4.9 Dép., diag. & prono. - Sein

John Bailar’s Righteous Attack on the “War on Cancer [Slate]

5. Traitements

Protein that inhibits and reduces the effects of chemotherapy identified [Karolinska Institutet]

5.10 Traitements - Essais

NCI Launches Formulary to Speed Availability of Investigational Cancer Drugs [RAPS]

5.12 Immunothérapies

CureVac's lead mRNA drug is down but not out, says CEO [FierceBiotech]

CureVac’s lead mRNA program flunks a critical PhIIb study, raising questions for high-profile biotech unicorns [EndPoints]

5.12.2 Immunothérapies - CAR-T

‘Amazing breakthrough … one step closer to a cure:’ Lessons from CAR-T coverage [HealthNewsReview]

5.12.3 Immunothérapies-combinaisons

Merck's Lead in Lung Cancer May Be Unbeatable [Bloomberg]

5.2 Pharma

Manufacturing Issues Stall Tesaro Cancer Nausea Drug at FDA [Xconomy]


5.2.1 Pharma - Partenariats

Pierre Fabre snags option on Piqur program in skin cancers [FierceBiotech]

5.2.3 Pharma - économie

As Trump fingers pharma on drug prices, execs step up with the latest vows of self discipline [EndPoints]

It’s the Drug Industry’s Turn to Tremble Before Trump [Bloomberg]


5.3 Traitements - FDA, EMA, NICE...

Multiple Endpoints in Clinical Trials: FDA Issues Draft Guidance [RAPS]

5.4 Traitements - Economie

NICE approves kidney cancer drug for NHS use [NICE]

NICE recommends Novartis’ kidney cancer drug [PharmaTimes]

NICE Issues Recommendations for Pembrolizumab in PD-L1-positive Locally Advanced or Metastatic NSCLC After Chemotherapy [ESMO]

6. Lutte contre les cancers

Cultural makeover in cancer research needed, Dean’s Lecture Series speaker argues [Stanford Medicine]

Will 2017 be the year when genomic medicine becomes business as usual? [PHG Foundation]


6.10.1 Politiques (USA)

As Trump attacks drug industry, few in Congress rush to its aid [STAT]

6.6 Publications

Journal retracts gastric cancer study with multiple duplications, authors MIA [Retraction Watch]

6.9 Controverses

The good, bad, and unknown about marijuana’s health effects [STAT]

The Health Effects of Cannabis and Cannabinoids: The Current State of Evidence and Recommendations for Research (2017) [Nationa Academies Press]

Pot has some medical benefits, U.S. Academies say, but obstacles to research loom [Science]

Most marijuana medicinal benefits are inconclusive, wide-ranging study finds [The Guardian]