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1. Biologie
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3.1 Tabac
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Study Finds No Safe Level of Smoking [NIH's Director Blog]
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As
published in JAMA Internal Medicine, the latest analysis included more
than 290,000 seniors who answered a survey conducted from 2004 to 2005.
The participants, divided up about evenly between men and women,
included approximately 111,000 never smokers, 156,000 former smokers,
and 22,000 current smokers.
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4.12 Biopsies liquides
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4.2 Dép., diag. & prono. - Génome
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5. Traitements
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5.12 Immunothérapies
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Algorithms compete to predict recipe for cancer vaccine [Nature]
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One
approach is to use algorithms to predict which bits of a mutated
protein might be seen by a T cell. These work by analysing where the
proteins could be cleaved, for example, and which of the resulting
fragments will bind tightly to the molecules that put them on display.
But each laboratory has a different “secret sauce”.
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5.12.1 Immunothérapies - partenariats
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5.2.3 Pharma - économie
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Not Fun Reading [In the Pipeline]
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Gosh,
where are all those drugs that we were assured a few years ago could be
(in fact, were) developed for only $43 million or so? That would
provide you with returns you could write home about, but it’s almost as
if that figure is completely wrong or something.
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5.3 Traitements - FDA, EMA, NICE...
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5.3.4 Traitements - AMM (FDA, EMA)
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5.4 Traitements - Economie
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We Need To Tame The Price Of New Cancer Drugs [Forbes]
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The
main problem with the DrugAbacus, which applies also to ASCO’s
published value framework, is the input of inaccurate or incomplete
information about how well drugs work. My concern is that overall
survival and other benefits may be systematically underestimated with
this tool, as they’re weighed by what clinical evidence led to first FDA
approval.
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5.7 SABCS
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6.10.1 Politiques (USA)
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