Onco Actu du 7 novembre 2016

	2.7 Etiologie - Obésité
Adult weight gain could increase cancer risk [Cancer Research UK] In the study of approximately 300,000 people in America, including around 177,500 men and 111,500 women, researchers categorised the population into five different lifetime weight trajectories**. They looked at changes in BMI between the ages of 18 and 65.
	3.1 Tabac
Every tobacco death is an avoidable tragedy. The epidemic must stop here [The Guardian] I urge global leaders convening in India to see this moment as an opportunity to bend the course of public health history and commit to returning home with a renewed dedication to fully implement the WHO framework convention.
	3.2 Prévention - Obésité
How GPs can encourage weight loss in just 30 seconds [Cancer Research UK] So this new study should be reassuring for GPs. It’s okay to bring up this sensitive subject. Even better, the discussion doesn’t have to take long, which is good news for GPs with a waiting room full of patients.
	4. Dépistage, diagnostic et pronostic
Brain tumour characteristics could help predict survival in people over 70 5Cancer Research UK] “Next we need to develop a guide for clinicians to improve how we treat elderly patients and to make decisions that could enhance quality of life.”
	4.1 Dép., diag. & prono. - Prostate
Tumour cells in blood samples could predict prostate cancer spread [Cancer Research UK] This is the first time these cell types have been shown to be a promising marker for prostate cancer spread.
	5.12 Immunothérapies
Gut microbes linked to immunotherapy response in melanoma patients [Cancer Research UK] This research suggests that adapting people’s gut bacteria, such as giving antibiotics, probiotics, or a faecal transplant before immunotherapy, could increase the benefits already achieved with new immunotherapy drugs now being used to treat several different types of cancer. However, this needs to be tested clinical trials.
Sick Dogs Could Be Key to Unlocking Mysteries of Immunotherapy [MIT Technology Review] This week an advisory committee at the National Cancer Institute at NIH said it will start a new program in 2017 to study experimental immunotherapies in dogs with cancer.
	5.12.3 Immunothérapies-combinaisons
Roche advances skin cancer trials as part of combination therapy strategy [Reuters] One study combined Tecentriq with Cotellic and Zelboraf in 30 patients with untreated BRAFV600 mutation-positive metastatic melanoma, the other Tecentriq with Cotellic for 10 patients with BRAF-wild-type and BRAF-mutant metastatic melanoma.
	5.2 Pharma
Regorafenib from Bayer Submitted to Health Authorities Seeking Approval in Second-Line Treatment of Liver Cancer [Bayer] Regulatory submissions in the U.S., Japan and Europe were completed based on data from the Phase III RESORCE study, in which regorafenib demonstrated statistically significant improvement in overall survival / Currently there are no approved therapies for the treatment of unresectable hepatocellular carcinoma (HCC) in the second-line setting.
AbbVie Receives FDA Orphan Drug Designation for Investigational Medicine Veliparib for the Treatment of Advanced Squamous Non-Small Cell Lung Cancer [AbbVie] AbbVie is currently investigating the efficacy and safety of veliparib in combination with chemotherapy or radiation for the treatment of advanced squamous NSCLC, including in Phase 3 studies. Veliparib is not currently approved to treat any form of NSCLC.
Bayer applies for Regorafenib authorization to treat liver cancer [Reuters] Bayer added that Regorafenib was accepted for an expedited approval process in the United States, known as a Fast Track designation.
	5.2.1 Pharma - Partenariats
Cancer Research UK and Cancer Research Technology partner with TYG Oncology to develop next generation cancer vaccine [Cancer Research UK] TYG100 is among a range of new treatments that use a patient’s own immune system to target hormones that encourage the growth and spread of solid tumours. It works by triggering the production of antibodies that specifically target two members of the gastrin hormone family* that help to fuel tumour growth.
	5.6 ESMO
ESMO Translational Research and Personalised Medicine Working Group: Open Positions [ESMO] The positions offer a unique opportunity for translational oncology scientists to support multiple ESMO translational research and personalised medicine projects and initiatives.
	6. Lutte contre les cancers
NCRI cancer conference 2016: Day 1 – lung cancer and yeast [Cancer Research UK] We’re up in Liverpool for the next 4 days reporting from the annual National Cancer Research Institute (NCRI) Cancer Conference.
Understanding cancer worries could break down barriers to seeking help [Cancer Research UK] Their findings show that about two thirds worry about the emotional impact of a cancer diagnosis and dying from cancer. This was closely followed by worries about cancer treatments, which were shared by 50 per cent of people.
Why I became a children’s cancer researcher – Richard’s story [Cancer Research UK] Through his research, Richard hopes to answer this burning question which has stumped scientists and doctors alike for decades: why, when treated the same way, do some children with brain tumours survive while others sadly don’t?
	6.1 Observation
'One-fifth of cancer patients face work discrimination' [BBC News] Almost one-fifth of people (18%) diagnosed with cancer face discrimination from employers or colleagues on return to work, research by the charity Macmillan suggests.
Over 130,000 patients a year are not receiving vital NHS cancer care on time [The Guardian] A total of 132,138 patients in England last year did not see a cancer specialist within the required 14 days or start treatment such as surgery or radiotherapy within the supposed maximum 31 after diagnosis, or 62 days after initial consultation and tests, according to an analysis of NHS-wide performance data conducted by Cancer Research UK.
Failure to meet cancer targets shows the NHS can no longer cope [The Guardian] This failure to meet targets, to keep up with the growing demand for cancer care, was a foreseeable problem – and it’s getting worse.
	6.5 Médecines alternatives
Cancer quackery from Germany to Australia [Science-Based Medicine] These German alternative medicine cancer clinics thrive based on the desperation of cancer patients with the means to travel to Germany or at least the means to raise the large sums of money required to travel to Germany and be treated at these clinics.