Onco Actu du 18 novembre 2016

	3.1 Tabac
Fred Hutch researchers mark Great American Smokeout with promising results for smartphone-based smoking-cessation app [Fred Hutch] App is available, free of cost, to Washington state residents.
	3.7 Alcool
135,000 alcohol-related cancer deaths predicted by 2035 [Cancer Research UK] The results were based on analyses that assume alcohol drinking trends will follow those seen over the last 40 years, and takes recent falls in alcohol consumption, including among young people, into account.
Alcohol-related cancer to kill 135,000 in England by 2035 – study [The Guardian] Alcohol-related cancers will cause about 135,000 deaths and cost the NHS £2bn over the next 20 years in England, unless concerted action is taken to highlight the dangers of drinking, health campaigners have warned.
	4.10 Dép., diag. & prono. - Poumon
Implementation of Lung Cancer Screening: Proceedings of a Workshop (2016) [National Academies Press] Given the individual and population health burden of lung cancer, especially when it is diagnosed at later stages, there has been a push to develop and implement screening strategies for early detection. However, many factors need to be considered for broad implementation of lung cancer screening in clinical practice.
	4.2 Dép., diag. & prono. - Génome
Large-scale cancer gene profiling is feasible but faces barriers [Dana-Farber Cancer Institute] The report contains data on 3,727 patients whose samples were analyzed during the first year of the Profile program at Dana-Farber/Brigham and Women’s Cancer Center and Boston Children’s Hospital.
	5. Traitements
Novel Machine-Learning Tool Opens Door to Improved Cancer Therapies [GEN] "We use machine learning to not only discover new membrane-active peptides, but to also identify membrane activity in known peptides with previously defined functions, leading us to discover membrane activity in diverse and unexpected peptide families."
	5.12 Immunothérapies
Bellicum, Molecular Templates Granted $32M for Immuno-Oncology Work [Xconomy] Bellicum’s BPX-501 can be used in stem cell transplants, and is designed to make other potentially risky cancer treatments safer for patients by preventing graft-versus-host disease—when the body thinks a transplanted cell is foreign.
	5.2 Pharma
Gilead’s rival to Incyte’s Jakafi stumbles in PhIII [FierceBiotech] Gilead plans to discuss the data with regulators before deciding how to proceed. But, even if the noninferiority result is enough to get momelotinib approved, the top-line data are bereft of reasons to think the JAK inhibitor can steal market share from Jakafi.
	5.2.1 Pharma - Partenariats
Genmab to trial daratumumab in combination with carfilzomib to treat multiple myeloma [European Pharmaceutical Review] The study will be conducted under a clinical trial collaboration and supply agreement between Genmab’s licensing partner for daratumumab, Janssen Biotech and Onyx Pharmaceuticals, a wholly-owned subsidiary of Amgen.
	5.3 Traitements - FDA, EMA, NICE...
Webinar: How can clinical research networks support developers of medicines for children? [EMA] Event to be broadcast live on 1 December 2016.
	5.4 Traitements - Economie
Roche drops price of breast cancer drug for NICE approval [PharmaTimes] Around 1,400 people in England and Wales would be eligible for treatment with Perjeta annually.
	6. Lutte contre les cancers
Walking may improve sleep with lung cancer [Reuters] Those who participated in a 12-week home-based walking program had better sleep quality at both three and six months after the program. The results reinforce similar findings in breast and colorectal cancer patients, researchers say.
	6.1 Observation
Children’s cancer death rates drop over 20 years [Cancer Research UK] The number of children dying from cancer each year in Great Britain has fallen from around 340 two decades ago to around 240 today.
Heart Disease and Cancer Deaths — Trends and Projections in the United States, 1969–2020 [Preventiong Chronic Disease]] If current trends continue, cancer will become the leading cause of death by 2020.
	6.10 Politiques
UK politicians demand Brexit guarantee for EU scientists [Nature] Influential committee says researchers need assurances they can stay after UK leaves European Union.
	6.9 Controverses
14-year-old girl who died of cancer wins right to be cryogenically frozen [The Guardian] Judge backs UK mother in allowing body of teenage daughter, who died of cancer, to be preserved in US – a process her estranged father opposed.