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3.1 Tabac
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US
Vice President elect Mike Pence (who has been the recipient of funding
from Big Tobacco) once famously wrote: Time for a quick reality check.
Despite the hysteria from the political class and the media, smoking
doesn’t kill. In fact two out of every three smokers does [sic] not die
from smoking-related illness and nine out of ten smokers do not contract
lung cancer.
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3.7 Alcool
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From
working out what on earth a unit of alcohol is, to clearing up some
myths about popular hangover cures, here’s what you need to know about
alcohol and cancer.
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4.12 Biopsies liquides
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The
researchers used an enhanced version of a technology they developed
called CAPP-Seq to predict which seemingly successfully treated patients
would relapse, or whose indolent lymphomas were becoming aggressive,
months before any clinical signs occurred.
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4.2 Dép., diag. & prono. - Génome
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The
Department of Veterans Affairs is gathering blood from 1 million
veterans and sequencing their DNA. At the same time, computer scientists
are creating a database that combines those genetic sequences with
electronic medical records and other information about veterans’ health.
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5. Traitements
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Scientists
are increasingly excited about a new area of research that aims to slow
or even halt the evolution of resistance. Among a number of potential
leads, research to target a family of molecules called APOBEC proteins
is causing a stir.
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If
researchers are successful in developing a drug that breaks up Aurora-A
and N-Myc’s friendship, without blocking Aurora-A’s normal job in cell
division, it could be turned into a potential treatment for
neuroblastoma and medulloblastoma.
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The
trial could take years, but American cancer patients are not waiting.
Over the past couple of years, dozens have slipped into Havana and
smuggled vials of the vaccine in refrigerated lunchboxes back to the
United States, sometimes not even telling their doctors.
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5.10 Traitements - Essais
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Individuals
who received the drug, cabozantinib, had a longer time to progression –
the interval before their cancer worsened – than those taking sunitinib
(Sutent), the drug that has been the standard initial treatment for
metastatic kidney cancer for the past decade.
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5.12.1 Immunothérapies - partenariats
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The
co-op deal, financial details of which were not published, will see the
two assess Pfizer’s ($PFE) OX40 agonist, its utomilumab and the German
Merck-partnered avelumab both alone and in various combos with other
meds, including chemo, radiation therapy and standard meds.
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Cooperative
Research and Development Agreement (CRADA) assesses OX40 agonist,
utomilumab and avelumab immuno-oncology assets alone and in various
combinations.
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Roche
will invest up to 100 million Swiss Francs to support basic and
clinical research collaborations related to cancer immunotherapy.
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The
research network of 21 academic centers around the world is intended to
support basic and clinical research collaboration to advance the
science of cancer immunotherapy, the Basel-based drugmaker said on
Tuesday.
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5.12.3 Immunothérapies-combinaisons
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In
the randomized phase I/II clinical trial known as CheckMate 032,
patients who progress after platinum-based chemotherapy received either
the anti-PD1 inhibitor nivolumab, or one of two combinations of
nivolumab plus the CTLA4 inhibitor ipilimumab.
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5.2 Pharma
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Novartis
pharmaceuticals unit, which received GSK's cancer drugs in the 2014
swap, also this year underwent a separate reorganization, in part to
direct its focus to oncology.
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5.3 Traitements - FDA, EMA, NICE...
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Changes are open for comments until end of February 2017.
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5.3.4 Traitements - AMM (FDA, EMA)
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In addition, EMA recommended extensions of indications for Novartis’ Arzerra (ofatumumab), Genzyme’s Caprelsa (vandetanib.
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5.4 Traitements - Economie
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With
the exception of Germany, most countries had a national and/or regional
drug budget. Germany is also unique in that only Germany and the UK
allow for free pricing, whereas other countries use reference pricing or
price negotiation.
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The
draft rejection follows a similar decision for Amgen’s Kyprolis last
week. NICE decided Kyprolis was not cost-effective for patients who’ve
had one prior therapy.
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5.7 SABCS
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Its
lead drug candidate PB272 (neratinib) will be featured in 11 poster
presentations at the 2016 San Antonio Breast Cancer Symposium (SABCS),
December 6 - 10, 2016, in San Antonio, Texas.
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5.9 AACR
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Preliminary Data for BLU-285 in Gastrointestinal Stromal Tumors (GIST) Accepted for Late-Breaking Oral Presentation.
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6.10 Politiques
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Tom
Crosby, medical director of the Wales Cancer Network, made his comment
as the Welsh Government launched its refreshed cancer delivery plan.
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6.11 Patients
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This is one in a series of occasional updates on the lives of people featured by STAT during our first year.
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Patients
without time to wait for a big taxpayer-powered breakthrough are
putting their trust in the latter. They’re trying to craft their own
individual moonshots with scraps of data they’ve collected from other
patients in Colontown, a members-only Facebook page for colorectal
cancer patients.
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6.5 Médecines alternatives
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Sadly,
SIO and the integrative medicine service at MSKCC are just two examples
of all too many. All over the US—the world, even—once rigorously
science-based institutions are embracing pseudoscience. Unfortunately,
the reasons they give are the same all over the world and just as
deluded.
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6.6 Publications
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Both
papers — which are more than a decade old — were pulled in The Journal
of Clinical Investigation on November 1 by their respective
corresponding authors.
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Data
availability and re-usability starts with best practices in collecting
and storing data in the first place. The exasperatingly funny video
below shows what happens when those best practices are ignored,
something that’s much more prevalent than it should be.
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