jeudi 13 octobre 2016

Onco Actu du 13 octobre 2016

1. Biologie

Rethink the links between genes and disease [Nature]

4.7 Dép., diag. & prono. - Col de l'utérus

ASCO Issues Global Recommendations to Increase Cervical Cancer Screening [ASCO]

4.9 Dép., diag. & prono. - Sein

Welch Et Al. Data in NEJM Reinforces That Mammography Detects Breast Cancers Earlier and Saves Lives [ACR]

Mammograms more likely to cause unneeded treatment than to save lives [STAT]

Breast Cancer Tumor Size, Mammography, and Screening Effectiveness [Now@NEJM]

Even More Evidence That Mammograms Have Been Oversold [FiveThirtyEight]

Majority of women diagnosed with breast cancer after screening mammograms get unnecessary treatment, study finds [LA Times]

Study finds high rate of overdiagnosis from mammograms [Reuters]

5. Traitements

PARP inhibitor plus epigenetic inhibitor reduces cancer growth and survival [FierceBiotech]

5.12.1 Immunothérapies - partenariats

Merck KGaA in Transgene cancer vaccine-checkpoint inhibitor test tie-up [FierceBiotech]

5.12.2 Immunothérapies - CAR-T

Adaptimmune looks to salvage ovarian cancer study by adding fludarabine to prep patients [EndPoints]

Tiny RXi bags an option to buy CAR-T fledgling MirImmune [EndPoints]

Safety concerns blight promising cancer therapy [Nature]

5.2.1 Pharma - Partenariats

Daiichi pens lung cancer pact with Dana-Farber, continuing oncology deal drive [FierceBiotech]

5.6.8 ESMO - Côlon-rectum

Boehringer's Vargatef comes up one endpoint short in colorectal cancer effort [FiercePharma]

6.1 Observation

Changes in depression symptoms tied to lung cancer survival [Reuters]

6.8 Communication

Skip The Math: Researchers Paint A Picture Of Health Benefits And Risks [NPR]

6.9 Controverses

The problem with p-values [AEON]