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1. Biologie
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4.7 Dép., diag. & prono. - Col de l'utérus
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ASCO Issues Global Recommendations to Increase Cervical Cancer Screening [ASCO]
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ASCO’s
guideline recommends that all women in appropriate age groups – in
low-resource, middle-resource and high-resource settings – be screened
for cervical pre-cancers. It specifically aims to establish consistent
minimum standards for screening across countries, while accounting for
wide variations in resource levels and health systems.
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4.9 Dép., diag. & prono. - Sein
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Study finds high rate of overdiagnosis from mammograms [Reuters]
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“This
new article will not change our guidelines,” said Dr. Richard Wender,
chief cancer control officer at the American Cancer Society, who was not
involved in the new research. It is simply showing a trend, which is
"the weakest form of evidence," he said.
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5. Traitements
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5.12.1 Immunothérapies - partenariats
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5.12.2 Immunothérapies - CAR-T
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Tiny RXi bags an option to buy CAR-T fledgling MirImmune [EndPoints]
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Said
Dr. Alexey Eliseev, CEO of MirImmune: “We treat therapeutic immune
cells with RNAi compounds ex-vivo to knock down immune checkpoints, such
as PD-1, LAG-3 and others. This treatment boosts the anti-tumor
activity of the cells when they are subsequently administered to the
patients.”
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5.2.1 Pharma - Partenariats
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5.6.8 ESMO - Côlon-rectum
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Boehringer's Vargatef comes up one endpoint short in colorectal cancer effort [FiercePharma]
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The
med, when paired with best supportive care, improved progression-free
survival in previously treated patients by 42%, Boehringer announced at
the ESMO 2016 Congress. But that benefit didn’t translate into an
improvement in overall survival. Now, Boehringer is analyzing the data
to better understand the outcome, lead study investigator Eric Van
Cutsem said in a statement.
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6.1 Observation
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6.8 Communication
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Skip The Math: Researchers Paint A Picture Of Health Benefits And Risks [NPR]
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What
Lazris and Rifkin especially want to combat is the practice of
discussing only relative benefits of medical procedures. Stating that a
mammogram lowers mortality risk from breast cancer by 20 percent says
nothing about how likely a person is to die of that disease in the first
place. Not to mention what the test might cost in pain, harm or hassle.
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6.9 Controverses
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The problem with p-values [AEON]
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Despite
the statistical mishaps, there have been enormous advances in
biomedicine. The reproducibility crisis is being tackled. All we need to
do now is to stop vice-chancellors and grant-giving agencies imposing
incentives for researchers to behave badly.
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