Onco Actu du 2 septembre 2016

	2.4 Etiologie - Portables, ondes e-m
Mobile phone health alarmists bereft of credible arguments [The Conversation] Predictably, several wrote to Cancer Epidemiology, setting out a litany of our egregious errors and failures to understand that an epidemic of brain cancer, comparable to the deluge of smoking-caused cancers, was just around the corner. Three of these were published this week with our response (open access until October 20, 2016).
	3.1 Tabac
American Cancer Society: Tobacco Has No Place in Pharmacies [ACS] ACS Calls on All Pharmacies to Stop Selling Tobacco.
	3.2 Prévention - Obésité
More than 57,000 children become overweight or obese during primary school [Cancer Research UK] Encouraging exercise and a sugar tax alone won’t curb the rise of ill-health which could cost the NHS billions. Commitments to protect children from junk food marketing and mandatory targets to reduce the amount of fat, sugar and salt in food are also vital.
	4.1 Dép., diag. & prono. - Prostate
A Math Model May Predict Time to Relapse After Prostate Cancer Surgery [AACR] Model developed using PSA tests may help clinicians better tailor a patient's therapy.
	4.12 Biopsies liquides
Blood test to spot new breast cancer subtype delays progression for twice as long [The Institute of Cancer Research] The test detects mutations to a gene called oestrogen receptor 1, or ESR1, which indicate that receptors for the female hormone oestrogen in the cancer cells that are usually driven by the hormone have evolved to stay permanently switched on without it — meaning hormonal treatments that block oestrogen production will no longer be effective.
	5. Traitements
Vitamin A may help control some cases of bowel cancer [Cancer Research UK] The research found that mice with bowel cancer caused by damage to the gut were found to have lower-than-normal levels of retinoic acid, which is made in the body from vitamin A, in their intestines. But when the team boosted retinoic acid levels in the animals’ gut, tumour growth was slowed.
Engineered Stem Cells Help Identify Potential New Treatment for Medulloblastoma [NCI] Based on this study, and others awaiting publication, the Children’s Oncology Group is exploring the possibility of including a CDK inhibitor in a clinical trial currently being planned for patients with relapsed medulloblastoma, said Dr. Raabe.
	5.12 Immunothérapies
Amgen obtains global development and commercial rights from Boehringer Ingelheim for investigational BiTE immuno-oncology drug for multiple myeloma [Boehringer Ingelheim] BI 836909 (AMG 420) targets B-cell maturation antigen (BCMA), a target in multiple myeloma due to its restricted normal tissue expression and uniform expression on multiple myeloma cells. BI 836909 (AMG 420) is currently being evaluated in Phase 1 studies.
	5.12.2 Immunothérapies - CAR-T
Hurdles abound in race to bring customized cancer treatments to masses [STAT] “I think the story line today is, CAR-T is really walking a fine line,” said Brad Loncar, founder of a cancer immunotherapy fund. “A year ago, there was definitely exuberance. But now, we’re on the precipice of people pulling back.”
	5.3 Traitements - FDA, EMA,...
FDA To Hold Two-Day Hearing on Off-Label Communications [FDA Law Blog] The types of questions that FDA is opening up for public comment suggest that FDA is significantly reshaping its approach on regulating a company’s off-label communications
	5.4 Traitements - Economie
NICE recommends Cancer Drugs Fund treatment for prostate cancer for routine NHS use [NICE] Radium-223 is offered to people who have prostate cancer which has then spread to the bone. NICE had previously recommended it only for patients who had received initial treatment with another drug called docetaxel.
Radioactive prostate cancer drug given NHS go-ahead [The Guardian] Radium-223 dichloride, marketed as Xofigo, could be made available for treating prostate cancer patients as early as December.
	6. Lutte contre les cancers
Fix the incentives [Nature] Fostering the connection between science funding and economic growth needs to be based on thoughtful measurement, says Julia Lane.
Voices: Waiting for Cancer [NY Times] My husband was adopted and wanted to learn more about his genetic makeup, so he selected an online genetics test, 23andMe, and out of curiosity, I decided to join him.
	6.10 Politiques
The Developing World Needs A Cancer Moonshot [Forbes] So what would a cancer moonshot for the rest of the world look like? Goss says it would start with a global online cancer registry.
	6.4 Médico-éco
Proton therapy demand wave drives expansion of Belgium's IBA [Reuters] According to IBA's own forecast, a worldwide increase to 20 percent of radiation patients treated with proton therapy would require the number of installed rooms to rise above 2,500.
	6.8 Communication
Cancer surgeons hesitant to tell patients the odds of a cure [Reuters] “As a patient, you cannot have a meaningful conversation about the surgery until you understand exactly what the surgeon means when he/she uses the word cure.”
	6.9 Controverses
Stop ignoring misconduct [Nature] Government officials should be prepared to pursue repayments. The threat of such penalties should have a chilling effect on investigators contemplating research misconduct, and motivate institutions to establish and implement policies that reflect their commitment to institutional integrity.