Onco Actu du 16 septembre 2016

	3.1.1 Tabac - e-cigs
E-cigarette brands make unvalidated claims their product helps people quit smoking [Stanford Medicine] “A huge number of e-cigarette companies do this,” said Robert Jackler, MD, senior author of the study and co-founder of Stanford Research Into The Impact of Tobacco Advertising. “They do it in clever and implicit ways. They imply that yes, ‘they work,’ but won’t say what they work for exactly.”
FDA protects kids from illegal sales of e-cigarettes, e-liquids and cigars [FDA] Agency issues first warning letters to retailers of newly regulated tobacco products.
FDA Warns Stores in Crackdown on E-Cigarette Sales to Minors [Bloomberg] High school students’ use of e-cigarettes rose more than 10-fold between 2011 and 2015, according to data from the FDA and the Centers for Disease Control and Prevention. Strict FDA regulations went into effect Aug. 8 on sales of tobacco products to minors that require retailers to check for a government ID for anyone under 27.
	3.7 Alcool
Could an app help you cut down on drinking and lower your risk of cancer? [Cancer Research UK] We caught up with a team at University College London (UCL) who have developed Drink Less, the first app that uses evidence and theory from the fields of behavioural science and addiction and applies it to help people cut down on their alcohol consumption.
	4.11 Dép., diag. & prono. - Ovaire
Company Stops Sales Of Ovarian Cancer Screening Test After FDA Warns Women Not To Use It [Forbes] Abcodia, a privately held London-based company with a Boston office, launched the $295 ROCA (“Risk of Ovarian Cancer Algorithm”) test last December in a few states.
	4.7 Dép., diag. & prono. - Col de l'utérus
More than two-thirds of cervical cancer deaths prevented by screening [Cancer Research UK] In England around 800 women die from cervical cancer each year. This new study suggests that without screening an additional 1,827 more women would die from the disease. But if all women aged between 25-64 were screened regularly an extra 347 lives could be saved – extensively reducing the number of deaths from the disease.
Cervical screening 'could save hundreds more lives' [BBC News] The research team analysed the records of more than 11,000 women in England who had been diagnosed with cervical cancer. The researchers found that 350 extra lives could be saved if all women aged between 25 and 64 were screened regularly.
Full uptake of cervical cancer screening could save hundreds of lives [The Guardian] New research has found that screening for cervical cancer is so effective that it prevents an estimated 1,827 deaths a year from it in England alone.
	5. Traitements
Discovery offers prospect of shorter treatment and cure for chronic myelogenous leukemia [Dana-Farber] Gleevec-like drugs plus Ezh2 inhibitors may offer cure without need for long-term treatment, researchers say.
Harder, better, faster, kinder – a new era for cancer drug testing [Cancer Research UK] “At the moment, cell lines are one of the best tools we have for studying cancer cells in the lab,” says Caldas. “But they are grown on plastic dishes in the lab, in an artificial setting. This is completely different from the extremely complicated way cells grow inside a patient’s body.”
New way of testing drugs could speed up development of breast cancer treatments [Cancer Research UK] This new technique means that researchers can carry out hundreds of drug tests after removing the cancer cells from mice. It is set to replace current practice of growing cancer cells on plastic dishes and transferring them to mice to carry out tests – an approach which has limitations because tumour cells grow differently in a plastic dish than in the human body.
	5.10 Traitements - Essais
Invasive early prostate cancer treatments not always needed [NHS Choices] Men may find it reassuring that few men died of prostate cancer during the study, and that choice of treatment didn't affect their survival chances 10 years after diagnosis. There are some points to be aware of, however.
The Numbers behind the ProtecT Trial [ACS] This week’s release of the first study comparing outcomes between surgery, radiation, and active surveillance got a lot of buzz. But even then, some pretty important details did not get as much coverage as they probably could, and maybe even should have.
Overall impressive: News media coverage of NEJM study on treating vs not treating prostate cancer [HealthNewsReview] We were pleased to see the coverage was overall solid, too: Robust sourcing, level-headed patient anecdotes and an accurate description of the findings were the norm in the dozen or so stories we looked at after the news came out this week.
	5.12 Immunothérapies
The gamma delta T cell gambit inspires a small London biotech startup with big ideas [EndPoints] If you run through the whole gamut of cell therapies being worked on in cancer research these days, gamma delta T cells aren’t likely to figure prominently in your review. But for years now Adrian Hayday, who runs labs at The Francis Crick Institute and King’s College London, has been fascinated by their unusual ability to penetrate into tissue, making them potential therapeutic candidates.
	5.12.2 Immunothérapies - CAR-T
Abingworth seeds I/O startup to exploit advance in solid tumor targeting T cells [FierceBiotech] The startup, GammaDelta Therapeutics, is focused on turning a breakthrough in the extraction and amplification of tissue-resident gamma-delta T cells into a pipeline of programs that can invade solid tumors more effectively than existing options.
	5.2 Pharma
After licensing out tremelimumab to AZ, Pfizer pays for another CTLA-4 mAb [FierceBiotech] Five years ago Pfizer gave much of the development rights to its CTLA-4 monoclonal antibody tremelimumab to AstraZeneca’s biologics arm--but today it has decided it wants to jump back into developing this cancer class after signing a deal worth $250 million with OncoImmune.
	5.2.1 Pharma - Partenariats
Come, Let Us Reason Together [In the Pipeline] One classic obstacle is the attitude towards publication. In academia, if it didn’t get published in a journal, it didn’t happen, whereas in industry journal publication is more of an “Oh, I guess so” affair.
	5.2.3 Pharma - économie
Dallas-Based Peloton Raises $52.4M for Kidney Cancer Drug Candidate [Xconomy] Founded in 2010, Peloton’s drug candidate, PT2385, is currently in phase I clinical trials for the treatment of advanced or metastatic clear cell kidney cancer.
	5.3 Traitements - FDA, EMA,...
EMA survey on initial marketing authorisation application 2016 [EMA] Once the survey is finalised and the responses analysed, the findings will be discussed with industry stakeholder associations in the stakeholder platform on the operation of the centralised procedure in the second quarter of 2017.
	5.3.4 Traitements - AMM (FDA, EMA)
New treatment for breast cancer [EMA] Ibrance (palbociclib) provides novel treatment option for women with advanced or metastatic disease.
New treatment for patients with soft tissue sarcoma [EMA] Lartruvo (olratumuab) recommended for conditional approval.
	6. Lutte contre les cancers
Review to speed up GP cancer referrals opens [Cancer Research UK] An audit of GP services in the UK has been launched today to find out how quickly cancer patients are referred, what tests they have and what referral pathways GP practices use.
Cancer patients not given painkillers soon enough, study finds [The Guardian] “Effective pain control is fundamental to good quality of life. For patients who are approaching the end of their lives, it is crucially important we strive to get this right and that we help them achieve the best quality of life possible.”
	6.1 Observation
Too soon to tell if 9/11 firefighters face increased cancer risk [Reuters] The current study found firefighters who responded to the attacks in New York don’t appear to have a greater cancer risk than firefighters from San Francisco, Chicago and Philadelphia who were not part of the 9/11 emergency response – with the exception of two cancer types.
	6.11 Patients
Living With Cancer: Unplugged and Unmoored [NY Times] For cancer patients, the net effect of the internet has been empowering, it seems to me, decreasing confusion and loneliness after diagnosis.
	6.5 Médecines alternatives
Chinese actor Xu Ting dies after choosing traditional medicine over chemotherapy [The Guardian] Xu said cost of chemotherapy and fears about side effects meant she would treat her cancer with Chinese therapies instead.
	6.6 Publications
Europe proposes copyright reform to help scientists mine research papers [Nature] Long-awaited plan would exempt computer-aided harvesting from EU copyright law.