Onco Actu du 29 août 2016

	1. Biologie
Stem Cells Drive Cancer Risk in Mice [The Scientist] Mutations that arise during stem cell division contribute to the development of cancers in a variety of organs, according to a study.
The Mystery of How Cancer Cells Barrel Through Your Body [Wired] From a practical point of view, all the theory papers in the world won’t make a difference if physicists cannot get biologists and clinicians interested in their ideas. Jamming is a hot topic in physics, but most biologists have not yet heard of it, Fredberg said.
	4.9 Dép., diag. & prono. - Sein
How much significance should health news give to statistically nonsignificant results? A case study of stories on skipping breast cancer chemo [HealthNewsReview] Rebecca Goldin, PhD, a professor of mathematical sciences at George Mason University and the director of STATS.org, agreed that it was unusual for NEJM to highlight a nonsignificant result in the study abstract without explicitly noting the lack of statistical significance.
	5. Traitements
Important advance made with new approach to “control” cancer, not eliminate it [OSU] The approach, called a “metronomic dosage regimen,” uses significantly lower doses of chemotherapeutic drugs but at more frequent time intervals. This would have multiple goals of killing cancer cells, creating a hostile biological environment for their growth, reducing toxicity from the drug regimen and avoiding the development of resistance to the cancer drugs being used.
	5.10 Traitements - Essais
Pancreatic cancer trial to make tumours more sensitive to treatment [Cancer Research UK] In the first part of the trial, the doctors want to find the safest dose of olaparib to give with chemoradiation. And in the second part of the trial, the doctors hope the combination will make the tumour small enough to be removed by surgery in these patients.
	5.3 Traitements - FDA, EMA,...
Transparency in Drug Regulation [ESMO] Publication of assessment reports in Europe and Australia makes information on medicines more easily available.
	5.4 Traitements - Economie
Gosh, Fellows, There’s a Better Way [In the Pipeline] I very much hope that the Drugs for Neglected Diseases Initiative gets its compounds to those who need them – but to pretend that they’re showing us the way beyond the grubby profit motive is just mistaken.
	6. Lutte contre les cancers
Rise of the super-sized genome projects [PHG Foundation] Most recently, the European Alliance for Personalized Medicine (EAPM) has called for a new project to link sequencing efforts across EU member states in a similar manner to the Genome Asia 100K, but to create a shared database of a million genomes from European populations for clinical research.
	6.1 Observation
Hodgkin survivors face risk of serious heart problems [Reuters] To assess the lasting effects of treatment on heart health, Bhakta and colleagues examined data on about 350 adults who survived at least a decade after their Hodgkin diagnosis, as well as about 270 people without a cancer history who were similar in gender and age.
	6.11 Patients
Cancer survivors want clear diet advice from their doctors and nurses [Cancer Research UK] Most patients in the study said they did not receive advice from their healthcare professionals about their diet and were keen to find out more. They said they received information about a healthy diet from charities, online and from the news but were confused about what makes up a balanced diet.
	6.6 Publications
We should reward peer reviewers. But how? [STAT] Elsevier, which publishes some 3,200 journals, is now piloting a way for reviewers to get props from their peers and editors. The plan, according to a note sent to reviewers, is to “publish on the journal’s website a list of reviewers with their full names and their relative ranking and percentile in how quickly they submitted their report (computed as days between the invitation to review and the submission of a referee report).”
	6.7.2 Applis
Why WhatsApp Could Be A Game-Changer for American Health Care [Fortune] Though WhatsApp’s encryption is a huge benefit in the medical world (for one thing, a hospital wouldn’t have to report it as a data breach if a doctor forgot his or her phone on a train), not everyone is convinced U.S. doctors will flock to it.