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1. Biologie
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PhD student Tim Wang uses CRISPR to take a big-picture approach to cancer research.
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“This
is the first experiment of this scale to differentiate the functional
consequences of tumor mutations, shedding important light on the myriad
rare mutations that are uncovered through clinical and research
sequencing.”
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5. Traitements
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By
creating a cell model of medulloblastoma from human cells rather than
working with mouse cells, the researchers say they can be more confident
that patients’ response to the drugs identified in the screenings may
be more comparable to humans.
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In
a set of studies in mice bearing human tumors, nanoparticles designed
to bind to a protein called P-selectin successfully delivered both
chemotherapy drugs and targeted therapies to tumor blood vessels.
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5.12.2 Immunothérapies - CAR-T
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After a long, intense pursuit, researchers are close to bringing to market a daring
new treatment: cell therapy that turbocharges the immune system to fight cancer.
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5.2 Pharma
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Takeda
has been talking about rearranging its R&D for months now, and
they’re finally gotten around to it. Their operations in the UK are
getting hit particularly hard, as the company says that Shonan, Japan
and Boston will be their two major R&D sites.
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Randomized
Phase 3 Clinical Trial with ADCETRIS Met Primary Endpoint,
Demonstrating Highly Statistically Significant Improvement in Rate of
Objective Response Lasting at Least Four Months.
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5.2.3 Pharma - économie
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Celgene
Corp. donated hundreds of millions of dollars to charities that help
patients afford high-priced drugs for multiple myeloma and other cancers
“as part of a core business scheme to gain billions” from U.S.
taxpayers, according to allegations in federal court filings.
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5.3 Traitements - FDA, EMA,...
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Main
changes include cutting one division dealing with human medicines (ie.
Going from four to three, with one division responsible for support to
medicines developers, one for the evaluation of medicines bringing
scientific and procedure management under one umbrella, and one for the
oversight of medicines, including pharmacovigilance and inspections).
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It
is important for the European Union medicines regulatory network to
gather information on the latest developments in big data from the
perspective of all stakeholders and to understand how the multitude of
data sources may contribute to medicinal product development,
authorisation and post-marketing surveillance in order to be in a
position to anticipate and prepare for such changes.
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European Medicines Agency employs 890 staff and is largest EU body in Britain but will have to be relocated after Brexit.
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6. Lutte contre les cancers
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Though
the system used by U.S. News isn’t regarded as scientific, directors of
cancer centers and folks in marketing pay close attention to even the
smallest of changes in the standing of their institutions.
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6.6 Publications
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Publons is a free service for reviewers, which enables them to gain public recognition for the reviews they complete.
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Increasingly popular social-media tool says it can maximize reach and impact of research.
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6.7 DMP, Big Data & applis
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CancerBase
provides patients with an easy-to-use method to share their
de-identified health data worldwide. The data is then displayed as a
global map of people with cancer, where different colored dots represent
people with different types of cancer.
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6.9 Controverses
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The institute's board was sent home after denying Christian Bréchot, who's almost 65, a second term.
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