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1. Biologie
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Halting Translation of Cancer-Promoting Proteins [GEN]
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Essentially,
the study points to a secret lever that triggers translation of a
special subset of mRNAs—perhaps only 500 out of some 10,000 mRNAs
produced by a cell. The study adds a new wrinkle to a familiar insight,
one that emerged more than 40 years ago, that a so-called initiation
protein must bind to a chemical handle on the end of each mRNA to start
it through the protein manufacturing plant, the ribosome.
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2. Etiologie
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Ovarian cancer risk nearly doubles in women who douche [Reuters]
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Prior
studies have linked douching, or vaginal washing with a device, to
yeast infections, pelvic inflammatory disease and ectopic pregnancies.
Researchers have also found associations between douching and cervical
cancer, reduced fertility, HIV and other sexually transmitted diseases.
But the new National Institute of Environmental Health Sciences study is
the first to tie cancer of the ovaries to the procedure routinely
practiced by millions of American women.
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5.12 Immunothérapies
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5.2.3 Pharma - économie
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Merck Needs Stronger Top-Line Medicine [Bloomberg]
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Merck's
cancer drug Keytruda has been absolutely dominated by Bristol-Myers
Squibb's own entry, Opdivo. Merck's drug requires doctors test patients
to identify suitable candidates. Bristol's drug can be prescribed
without that step and reaches more patients, giving it a major
advantage.
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5.3 Traitements - FDA, EMA,...
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Modelling and simulation in the development and regulatory review of medicines [EMA]
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Using
specialised software platforms, these models aim to simulate the
concentration of a medicine in the body over time. They are increasingly
used by medicine developers for various purposes such as predicting the
interaction between medicines in the body or helping to define the
initial dose of a medicine in paediatric and first-in-human trials.
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5.4 Traitements - Economie
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6. Lutte contre les cancers
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6.10 Politiques
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6.10.1 Politiques (USA)
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Why Democratic convention viewers saw so many drug ads [STAT]
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Democratic
politicians made a few jabs at the pharmaceutical industry at their
convention this week, but viewers tuning in at home saw something of a
counterargument during commercial breaks: a stream of ads promoting
drugs — and the drug industry.
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6.4 Médico-éco
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NHS under pressure from increase in cancer survivors, report warns [The Guardian]
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Around
625,000 people in the UK are estimated to be facing poor health or
disability after treatment for cancer. Long-term consequences can range
from painful lower-leg swelling in women following breast cancer to
emotional trauma, and with the number of people living with cancer in
the UK set to grow from 2.5 million to 4 million by 2030, more people
will need support.
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6.7 DMP, Big Data & applis
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