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1. Biologie
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2. Etiologie
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3.2 Prévention - Obésité
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4.1 Dép., diag. & prono. - Prostate
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4.10 Dép., diag. & prono. - FDA, EMA, NICE,...
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4.7 Dép., diag. & prono. - Col de l'utérus
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4.9 Dép., diag. & prono. - Sein
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5. Traitements
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5.12 Immunothérapies
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5.12.2 Immunothérapies - CAR-T
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Feuerstein: Juno Patient Deaths Crash Cancer-Killing CAR-T Party [The Street]
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The
company intends to quickly submit paperwork to the FDA to amend its
study so that fludarabine is no longer used. Juno hopes the FDA concerns
are satisfied and the clinical hold can be lifted but there are not
guarantees. Previous guidance from Juno that JCAR015 could be approved
in 2017 is now off the table.
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After Three Deaths, FDA Halts Juno's Leading CAR-T Trial [Xconomy]
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Juno’s
decision to “precondition” all its CAR-T recipients—not just those
getting JCAR015—with fludarabine and cyclophosphamide came last year,
after Juno collaborator Cameron Turtle of the Fred Hutchinson Cancer
Research Center in Seattle showed that patients fared better when
receiving the combination before another T cell therapy, JCAR014.
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Juno Therapeutics Stops Trial Of Cancer-Killing Cells After 3 Patient Deaths [Forbes]
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Bishop
says that the culprit appears to be a new drug, the chemotherapy
fludarabine, that Juno recently added to the trial, called ROCKET. In
the CART treatment, patients are first given a chemo cocktail that kills
their existing T-cells. This gives the new T-cell, genetically
re-engineered to attack cancer, room to grow. Juno has previously
presented work showing that adding a drug called fludarabine to the
chemotherapy makes the CART cells take root faster.
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5.2.2 Pharma - Fusions & Acquisitions
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Medivation Overplays a Risky Hand [Bloomberg]
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Medivation
will probably get more than $3 a share for talazoparib. But it needs to
be realistic about getting a best-in-class valuation for the drug -- or
the nearly $3 billion market-cap boost Tesaro's data inspired --
without more proof.
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5.4 Traitements - Economie
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Q&A: Why the World Health Organization plans a fair pricing model for drugs [STAT]
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The
trick is to find the right balance between access to affordable
medicines and enticing companies to develop new and improved medicines,
while also ensuring lower-cost generics remain available. We spoke with
Suzanne Hill, the secretary to the WHO Expert Committee on the Selection
and Use of Essential Medicines, about how the agency hopes to get this
done.
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6.10.1 Politiques (USA)
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Medicine’s next step - Barack Obama [The Boston Globe]
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Precision
medicine gives us the chance to marry what’s unique about America — our
spirit of innovation, our courage to take risks, our collaborative
instincts – with what’s unique about Americans – every individual’s
distinctive genetic makeup, lifestyles, and health needs.
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6.6 Publications
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