Onco Actu du 6 juillet 2016

	1. Biologie
Study sheds light on role of mutations in metastasized cancer [MIT News] Researchers identify genes that mutate in endometrial cancer, create a family tree describing the evolutionary history of the disease.
	2.4 Etiologie - Portables, ondes e-m
ABC Catalyst's future under review after episode linking Wi-Fi and cancer [The Guardian] A review found that the program failed to present the weight of scientific evidence on the topic, and that credible peer-reviewed science was ignored in favour of the unorthodox and unsubstantiated view that wireless devices and Wi-Fi pose a significant health risk.
	3. Prévention
Helpless to Prevent Cancer? Actually, a Lot Is in Your Control [NY Times] About 82 percent of women and 78 percent of men who got lung cancer might have prevented it through healthy behaviors. About 29 percent of women and 20 percent of men might have prevented colon and rectal cancer. About 30 percent of both might have prevented pancreatic cancer. Breast cancer was much less preventable: 4 percent.
	3.1 Tabac
NCI’s Next Decade of Tobacco Control Research [National Cancer Institute] The working group’s report provides a comprehensive guide that will help direct our research efforts moving forward. For example, it recommends a focus on improving the efficacy of new and existing smoking prevention and cessation interventions, including making them more accessible, whether that’s via an app for a smart phone or in nontraditional care settings like emergency departments and mental health and substance abuse treatment centers.
	3.2 Prévention - Obésité
The Urgency in Fighting Childhood Obesity [NY Times] Two new studies, conducted among more than half a million children in Denmark who were followed for many years, linked a high body mass index in children to an increased risk of developing colon cancer and suffering an early stroke as adults.
	5. Traitements
New microfluidic device offers means for studying electric field cancer therapy [MIT News] The device, about the size of a U.S. dollar coin, is designed to help scientists narrow in on safe ranges of electric fields to noninvasively treat breast, lung, and other forms of cancer. The results are published online in Scientific Reports.
	5.12 Immunothérapies
Immune-based therapy in mice shows promise against pancreatic cancer [WUSTL] Mice with a model of pancreatic cancer survived no longer than two months when given either a FAK inhibitor or immune therapy alone. Adding FAK inhibitors to standard chemotherapy improved tumor response over chemotherapy alone.
	5.2 Pharma
XBiotech Cancer Drug Survival Claim Falls Apart Under Scrutiny [The Street] If the messy, confused clinical data disclosed Saturday by XBiotech are any indication, an approval in Europe for its colon cancer drug is far from a sure thing.
	5.2.2 Pharma - Fusions & Acquisitions
Bristol-Myers Squibb Boosts Cancer Drug Pipeline with Cormorant Deal [Xconomy] Key to the deal is Cormorant’s lead drug candidate, HuMax-IL8, a monoclonal antibody in Phase 1/2 clinical trials that targets the IL-8 protein, a protein found on many solid tumors that has the effect of suppressing the immune system.
	5.2.3 Pharma - économie
Merck Invests in RNA Startup to Target Cancer [MIT Technology Review] Merck wants to combine its expertise in cancer immunotherapy with Moderna’s personalized cancer vaccines so that the two treatments together can more effectively target cancer.
	5.4 Traitements - Economie
Nivolumab for previously treated advanced renal cell carcinoma [NICE] The committee concluded that, even when applying the maximum weighting to the QALY hat is possible under the end-of-life criteria, the ICER for nivolumab did not fall ithin the range of a cost-effective treatment.
Nice rejects BMS’ immunotherapy Opdivo for previously treated kidney cancer on pricing [Pharmafile] The National Institute for Health and Care Excellence (Nice) said the incremental cost-effectiveness ratio (ICER) was above £60,000 per quality-adjusted life year (QALY) gained.
	5.5.8 ASCO (poumon)
Non-Small Cell and Small Cell Lung Cancers: Immediate Impact of 2016 ASCO Presentations on Clinical Practice [The OBR Blog] Responses are from 14 countries: Austria, Belgium, Brazil, Canada, France, Germany, Italy, japan, Poland, Spain, Switzerland, Turkey, United Kingdom and US.
	6. Lutte contre les cancers
Stanford Cancer Institute Earns Highest Cancer Center Designation [Scope Blog] The National Cancer Institute (NCI) has recognized the Stanford Cancer Institute as one of the top cancer research centers in the United States. An NCI-designated Cancer Center since 2007, the SCI has worked for the last several years to increase the breadth, depth and coordination of its research programs in order to earn the NCI’s highest cancer center status: as a ‘Comprehensive’ Cancer Center.
	6.6 Publications
First Oncology Society Partnership for New ESMO Open Access Journal [ESMO] ESMO, the leading European professional organisation for medical oncology, is delighted to announce that the Italian Association of Medical Oncology has formally adopted ESMO Open as its scientific journal.
U.K. research charity will self-publish results from its grantees [Science] Publication will be limited to the thousands of scientists worldwide working on research funded by a Wellcome grant, and it will be free not only for readers, but authors—the charity is covering the costs charged by the company that will provide the journal's software and online platform.
Let’s make peer review scientific [Nature News & Comment] Thirty years on from the first congress on peer review, Drummond Rennie reflects on the improvements brought about by research into the process — and calls for more.