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1. Biologie
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Scientists program C2c2, discovered in bacteria as a viral defense mechanism, to manipulate cellular RNA.
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“If
C2c2 can be engineered such that the RNA cleaving activity is specific
and no collateral RNA molecules are targeted, then this new tool could
provide a much faster way of knocking down gene products over CRISPR
interference or CRISPR nuclease which both act at the DNA level.”
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2. Etiologie
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Schildkraut,
an epidemiologist at the University of Virginia in Charlottesville, had
been skeptical of a long-debated connection between genital talc and
the deadly gynecologic cancer. But her new study, in concert with other
recent research, convinced her to advise women to avoid using talcum
powder.
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4.10 Dép., diag. & prono. - Poumon
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The
study authors cautioned that their estimates are based on statistical
models rather than on observed outcomes. The models involve certain
assumptions about implementation of the risk-based screening strategy,
and more research would be needed to determine the most effective way to
implement the strategy, they wrote.
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5. Traitements
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While
this may be an important discovery, and could hopefully pave the way to
more targeted treatments, the research has so far only been performed
in cells in the lab.
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5.10 Traitements - Essais
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We
find ourselves at a crucial point in the history of RCTs. Originally
designed to reduce bias in research, RCTs have become sites of
conflicting interests that merit careful scrutiny.
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Most
of the criticisms of RCTs made in the article are completely in error.
For this reason, the article is a subtle threat to the pursuit of
evidence-based medicine and a threat to better decisions for patients.
And, precisely because it is subtle, its danger is all the greater.
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5.12 Immunothérapies
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While
the scientific advances are important and could lead to future
treatments, we don't yet know whether this approach is safe, effective
or practical in humans.
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While
Sansom and others continue to unravel these complex issues, there’s a
more pressing question. Could combining CXCR2 drugs with checkpoint
inhibitors help make immunotherapy work for pancreatic cancer patients?
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Dr
Jennifer Morton, lead researcher of the study, which is published in
Cancer Cell, said: “One of the most striking effects of blocking CXCR2
was the rush of T-cells into the tumour."
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5.12.2 Immunothérapies - CAR-T
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Cell
Design Labs' Reversible ‘On/Off Switch' Technology Provides Dynamic
Range of Control to Precisely Regulate Activity of Engineered CAR
T-Cells.
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5.2 Pharma
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Here’s
an updated look at clinical success rates in the biotech industry, from
the BIO industry organization. They’re looking at only
company-sponsored programs aimed at FDA registration, nothing
investigator-sponsored, and it’s a big data set.
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This
report examines several types of cancer where significant advances over
the last decade have improved outcomes for patients and are opening
doors to new avenues of research.
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5.3 Traitements - FDA, EMA,...
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I
understand Senator Rubio’s desire to advocate for drugs for rare
diseases. But he ought to leave the complexities of drug evaluation and
review to experienced FDA scientists.
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The
FDA has a long history of supporting patient access to investigational
treatments and we hope the information released today will help health
care professionals, patients, and industry to more easily navigate the
expanded access process and help patients who qualify to gain access to
potentially life-saving investigational treatments.
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5.4 Traitements - Economie
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The
IMS report shows that, although the savings when drugs lose their
exclusivity has been considerable, it has been counteracted by the price
increases on existing drugs.
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Of
the drugs approved in 2014 and 2015, only the US, France, and Scotland
have more than half included on reimbursement lists at the end of 2015,
according to IMS.
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In
this report, we share our updated perspective on some of the trends we
have observed in 2015, including new treatment options, availability of
cancer treatments, costs of oncology therapeutics and supportive care
drugs, distribution of cancer drugs, and some of the dynamics that are
specific to the U.S. as well as an outlook to 2020.
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5.5 ASCO
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New
Solution Provides a Curated Insight into Patient Genomics. The
announcement was made today at the 2016 American Society of Clinical
Oncology (ASCO) Annual Meeting.
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5.5.1 ASCO (général)
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Two abstracts will be presented in Oral Abstract Sessions, nine in General Poster Sessions and one publication.
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5.5.1.1 ASCO (général) - Industriels
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Immunomedics
was caught trying to sneak old, previously presented clinical data on
its triple-negative breast cancer drug IMMU-132 into the American
Society of Clinical Oncology (ASCO) annual meeting.
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5.5.13 ASCO (divers)
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Of
all the reports being presented at this year’s big cancer meeting, the
one I think most important is not about a particular drug or malignancy.
It’s about the design of clinical trials.
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5.5.4 ASCO (immunothérapies)
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Talking
about recent progress against melanoma, the first cancer to be targeted
by immunotherapy, Dr Daniel Hayes, incoming ASCO president, summed up
the cautious shift: "It makes us wonder if we can use the word "cure.'"
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6. Lutte contre les cancers
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Researchers
analyzed survey data from more than 5,400 people who had diagnostic
imaging at a comprehensive cancer center to see how much these patients
knew about ionizing radiation, a type of energy that is strong enough to
penetrate the body and help create images of internal organs.
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Mindfulness
Based Stress Reduction classes, which tend to cost around $200, are
widely available at hospitals and privately, as well as through online
programs such as the one offered by the University of Massachusetts
medical school.
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6.1 Observation
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New report by the American Cancer Society projects 20 million cancer survivors in the U.S. by 2026.
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6.10 Politiques
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The
state Senate on Wednesday approved legislation that would mandate
companies to disclose any increase in the list price of a medicine by
more than 10 percent during any 12-month period. And drug makers would
also have to explain price hikes for medicines with a list price of more
than $10,000 within 30 days of making such a move.
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6.11 Patients
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The
poignancy of Mr. Scheuer’s and Ms. Lerner’s images arises from the
implacable effect that estranging clinical spaces impose on previously
secure domestic places.
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6.5 Médecines alternatives
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Stanislaw
Burzynski has had 40 years to prove that his ANPs have anticancer
activity. Even given opportunity after opportunity, he’s utterly failed.
Tedeschi and Kaplan should realize that, but they didn’t.
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6.7 DMP, Big Data & applis
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The site has been organized to meet the needs of patients, practices, donors, researchers, and the larger oncology community.
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6.9 Controverses
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Some admire project's ambition; others say it hasn't justified its aims.
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A
proposal by a group of scientists and businesspeople to synthesize a
human genome from scratch is attracting sharp criticism for dodging the
big ethical questions such a step raises. The proposal, described today
in a two-and-a-half-page letter being published in Science, is to string
together synthetically made DNA and shape from it a human genome able
to power a cell in a dish.
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