Onco Actu du 26 avril 2016

	3.1 Tabac
Chantix smoking-cessation pill does not increase risk of suicide: study [STAT] The study, which involved more than 8,100 people, was ordered by the US Food and Drug Administration following ongoing reports of neuropsychiatric side effects for Pfizer’s Chantix and Zyban, which is made by GlaxoSmithIKline.
	4.2 Dép., diag. & prono. - Génome
Everything you really need to know about DNA sequencing - Cancer Research UK - Science blog So how exactly does that technology work, and how is it helping? To answer that question we have to go back to where it all began.
	5.10 Traitements - Essais
Childhood Leukemia Relapse Rates Improve with High Doses of Chemotherapy Drug Methotrexate [NYU Langone Medical Center] This was a large-scale study involving pediatric cancer centers across the country. More than 3,000 patients with high-risk ALL were enrolled in the randomized clinical trial, which was run by the Children’s Oncology Group, a multi-institutional clinical trials consortium supported by the National Cancer Institute.
	5.12 Immunothérapies
Targeted Photoimmunotherapy for Cancer [National Cancer Institute] Two new studies from NCI researchers add to growing evidence of the promise of a novel type of cancer immunotherapy that uses infrared light to activate rapid and selective killing of cancer cells.
	5.2 Pharma
Bristol-Myers Squibb’s Opdivo® (nivolumab) Receives Breakthrough Therapy Designation from U.S. Food and Drug Administration for Previously Treated Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck [BMS] Designation based on results of Phase 3 study, CheckMate -141, in which Opdivo met its primary endpoint of overall survival, versus three standard of care options in this patient population.
	5.2.3 Pharma - économie
Supreme Court skeptical in case backed by drug makers [STAT] The generic companies and insurers allege that the industry exploits the patent system to preserve monopolies on drugs, preventing generics from entering the market and keeping prices high. The new reviews will help bring drug costs down, they say.
	5.3.4 Traitements - AMM (FDA, EMA)
Exelixis Announces FDA Approval of CABOMETYX™ (Cabozantinib) Tablets for Patients with Advanced Renal Cell Carcinoma Who Have Received Prior Anti-Angiogenic Therapy [Exelixis] CABOMETYX, which was granted Fast Track and Breakthrough Therapy designations by the FDA, is the first therapy to demonstrate in a phase 3 trial for patients with advanced RCC, robust and clinically meaningful improvements in all three key efficacy parameters — overall survival, progression-free survival and objective response rate.
	5.4 Traitements - Economie
Germany Is New Battlefield for Drugmakers Facing Price Scrutiny [Bloomberg] In response to continuing criticism of the high costs of that drug, health minister Hermann Groehe aims to bring in new laws to ease the burden on the state insurers until a discount can be negotiated, and will introduce a draft proposal this summer.
	5.9 AACR
Vice President Joe Biden Speaks at the AACR Annual Meeting 2016 [CANCER RESEARCH Catalyst] Biden vowed to fix the limitations and redundancies that can choke federal funding mechanisms, and to facilitate federal support of projects that promote coordination, collaboration, and out-of-the-box thinking.
	6. Lutte contre les cancers
Ovarian Cancers: Evolving Paradigms in Research and Care [The National Academies Press] "Ovarian Cancers" examines the state of the science in ovarian cancer research, identifies key gaps in the evidence base and the challenges to addressing those gaps, considers opportunities for advancing ovarian cancer research, and examines avenues for translation and dissemination of new findings and communication of new information to patients and others.
	6.1 Observation
30 years since Chernobyl and 5 years since Fukushima – What have we learnt? [Cancer Research UK] It’s important to keep in mind that this kind of increased surveillance can also mean that more cancers are found – simply because we’re looking for them – including cancers that would never have caused harm in someone’s lifetime – this is called overdiagnosis. And thyroid cancer seems particularly prone to overdiagnosis.
	6.6 Publications
You Pay to Read Research You Fund. That’s Ludicrous [WIRED] We need to change the model, not just tweak around the edges. An alternative system, where all publicly-funded research is required to be shared under a permissive license, would allow authors to unlock their content and data for re-use with a global audience, and co-operate in new discoveries and analysis.
	6.8 Communication
Should science only be reported by journalists with a scientific background? [The Institute of Cancer Research] When a room full of PhD students from The Institute of Cancer Research, London, held a debate about science journalism, most initially agreed that journalists covering science stories should have a science background. But would hearts and minds be swayed by a panel of experts on both sides of the debate?