Onco Actu du 11 avril 2016

	2.11 Etiologie - Alimentation
Pig drug poses potential cancer risk to pork consumers, FDA says [STAT] “This is a fairly rare move,” said Steven Roach of Food Animal Concerns Trust, an advocacy group.
FDA takes steps to withdraw approval of the swine drug carbadox due to safety concerns [FDA] “The manufacturer of carbadox has failed to provide sufficient scientific data to demonstrate the safety of this drug given evidence that carbadox may result in carcinogenic residues.”
FDA to revoke pig drug approval over human cancer risk concern [Reuters] "Potential cancer risks are based on an assumed lifetime of consuming pork liver or other pork products containing carbadox residues," the agency said in a statement, adding that it is not recommending that people change their food choices while it works to remove the drug from the market.
	3.1 Tabac
Are E-Cigarettes a Healthy Way to Quit Smoking? [Wall Street Journal] Some people say electronic cigarettes can help wean smokers off tobacco, at little risk to their health. For others, both of those assertions are false.
	4. Dépistage, diagnostic et pronostic
First cancer patient in Europe scanned in Cambridge using new technique showing whether drugs work [Cancer Research UK] "The next steps for this study will be collecting and analysing the results to find out if this imaging technology provides an accurate early snapshot of how well drugs destroy tumours.”
New test measures cancer drugs success [BBC News] The scan monitors how quickly pyruvate is broken down by cancer cells - and that gives doctors an idea of how active those cells still are.
NHS Wales urged over cancer diagnosis change [BBC News] Dr Tom Crosby, medical director of the Wales Cancer Network, said: "What they've demonstrated [in Denmark] is that what's taking us weeks and months in Wales to diagnose patients, particularly with those vague and non specific symptoms, they're now doing in a matter of days and there's nothing they're doing here that we can't do in Wales."
	4.12 Biopsies liquides
US hospital commits to lung cancer ‘liquid biopsy’ [Cancer Research UK] The accuracy and reliability of the test was examined in 180 patients with NSCLC, including 120 newly diagnosed patients and 60 who had seen their disease return and become resistant to treatment.
	4.9 Dép., diag. & prono. - Sein
Known biomarker for breast cancer also predicts risk [PHG Foundation] Women with a higher percentage of the molecular marker Ki67 are five times more likely to develop breast cancer, says a new study.
	5. Traitements
Artificial DNA could build new generation of cancer drugs [The Institute of Cancer Research] The team from The Institute of Cancer Research, London, and the University of Cambridge created microscopic pyramid- and diamond-shaped 3D ‘packets’ by folding together artificial nucleic acid building blocks called Xeno nucleic acids (XNAs).
New Approach Shows Promise for Overcoming Chemoresistance [GEN] The team discovered that tumors that responded to treatment initially relied mainly on growing their own blood vessels, but developed resistance to treatment by actively stealing the normal pre-existing blood vessels of the liver instead.
How an obscure medical technology caught the eye of Joe Biden. And John Grisham [STAT] Focused ultrasound, as the procedure is known, is used commercially in the United States to treat just a few medical conditions, including uterine fibroids and prostate cancer. Just over two dozen hospitals and clinics across the country offer it. Hardly any insurers will pay for it.
	5.12 Immunothérapies
Juno Therapeutics And WuXi AppTec Announce New Company To Develop Novel Cell-Based Cancer Immunotherapies In China [TheStreet] Juno and WuXi AppTec have equal initial ownership in JW Biotechnology ( Shanghai) Co., Ltd, which after meeting certain conditions will have access to licensing product candidates from Juno's pipeline for development and commercialization in China.
	5.2 Pharma
Celgene says disappointed with NICE decision to not back blood cancer drug [Pharmafile] The company said Azacitidine has the potential to provide a vital life-line to eligible people with AML adding the late stage trials for the drug showed a median improvement in survival of 3.8 months compared with conventional care regimens.
FDA Grants Priority Review for Genentech’s Cancer Immunotherapy Atezolizumab in Specific Type of Lung Cancer [Genentech] This is the second BLA acceptance and priority review for atezolizumab.
Roche says FDA fast tracks atezolizumab in specific type of lung cancer [Reuters] The designation covers treatment of patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) whose disease expresses the protein PD-L1 as determined by an FDA-approved test, and who have progressed on or after platinum-containing chemotherapy.
	5.2.1 Pharma - Partenariats
Flatiron Health Announces Strategic Relationships with Celgene and Amgen to Further Advance Personalized Medicine for Cancer Patients and Accelerate Clinical Research [Flatiron] To help researchers and life science companies answer a broad range of exploratory commercial, medical and research questions, Flatiron Health combines industry-first technology, proprietary data processing capabilities and an extensive understanding of oncology to deliver a continuously aggregating data resource.
	5.3 Traitements - FDA, EMA,...
Clovis Smart Move is to Drop Damaged Lung Cancer Drug Altogether [TheStreet] The insurmountable challenge facing Clovis is rociletinib is significantly less effective than its direct competitor, the lung cancer drug Tagrisso from AstraZeneca, which is already approved.
FDA staff questions Clovis drug's benefit over current treatments [Reuters] The drug, rociletinib, like rival Tagrisso from AstraZeneca Plc, aims to treat a sub-set of patients with advanced non-small cell lung cancer whose disease has worsened despite treatment.
	5.4 Traitements - Economie
Non-haematological cancer treatment market to almost double by 2021 [European Pharmaceutical Review] Market drivers will include the increasing prevalence of cancer globally, and the introduction of more targeted treatments, which will improve the overall survival of poor-performance-status patients and enable more rounds of chemotherapy to be administered.
	6.1 Observation
Marriage boosts survival chances of cancer patients, say scientists [The Guardian] “We really want to highlight the awareness factor here that unmarried people perhaps could be considered a high-risk, vulnerable population.”