Onco Actu du 7 mars 2016

	2.6 Etiologie - Environnement
Mystery cancers are cropping up in children in aftermath of Fukushima [Science] “It is inappropriate to compare the data from the Fukushima screening program with cancer registry data from the rest of Japan where there is, in general, no such large-scale screening,” Richard Wakeford, an epidemiologist at the University of Manchester in the United Kingdom, wrote on behalf of 11 members of a WHO expert working group on Fukushima health consequences.
EU states rebel against plans to relicense weedkiller glyphosate [The Guardian] France, the Netherlands and Sweden have all said they will not support an assessment by the European food safety authority (Efsa) that glyphosate is harmless.
	3.4.1 Chimioprévention - aspirine
Can aspirin reduce bowel cancer risk? [NHS Choices] Until this risk-benefit balance is better understood, no recommendation can be given for everyone to start taking daily aspirin to reduce cancer risk.
Quantifying Aspirin’s Reduction in Cancer Risk [NY Times] “Based on our estimates,” Dr. Chan said, “we think that regular aspirin use could prevent almost 30,000 cases of gastrointestinal cancers a year, which account for almost 25 percent of all cancer deaths. So I think that’s pretty substantial.”
	4. Dépistage, diagnostic et pronostic
ASCO Commends IOM Report “Biomarker Tests for Molecularly Targeted Therapies” [ASCO] CancerLinQ will fulfill the IOM’s recommendation for the implementation of a rapid learning system that will track long-term patient outcomes related to the use of biomarker tests and targeted therapies. However, the current lack of interoperability among clinical databases and with genomic data sets is a major roadblock to achieving the promise of precision medicine.
Biomarker Tests for Molecularly Targeted Therapies: Key to Unlocking Precision Medicine [The National Academies Press] This report explores regulatory issues, reimbursement issues, and clinical practice issues related to the clinical development and use of biomarker tests for targeting therapies to patients. Properly validated, appropriately implemented biomarker tests hold the potential to enhance patient care and improve outcomes, and therefore addressing the challenges facing such tests is critical.
	5. Traitements
Fighting Cancer By Putting Tumor Cells On A Diet [NPR] He points out that data supporting the ketogenic diet in cancer are limited – and further that rigorous dietary studies are incredibly hard to pull off. "The drug companies aren't going to fund these types of trials," he says. "They can't make money marketing a diet."
	5.12 Immunothérapies
Jimmy Carter says he no longer needs cancer drug treatment [AP] Medical experts have called Keytruda and similar immune therapy drugs "game-changing" for patients with melanoma. But the drugs are relatively new, and doctors are still learning about how they should be used and for how long, said Dr. Len Lichtenfeld, deputy chief medical officer for the American Cancer Society.
Cancer Research UK explains how immune cells could tackle tumours – video [The Guardian] This animation by Cancer Research UK explains the new findings which could revolutionise cancer treatment.
Cancer Immunotherapy 2016: En Bloc Analysis of the Publications Landscape Uncovers Trends in the Space [GEN] We parsed 16,988 publications in the broader cancer immunotherapy space (originating from both academia and industry), of which 4671 contained the term “cancer immunotherapy” in the title or abstract of the publication.
	5.2.1 Pharma - Partenariats
Baxalta dumps Onconova's cancer drug in the midst of Phase III [FierceBiotech] The treatment, rigosertib, is in development for myelodysplastic syndrome, a rare bone marrow disorder that often develops after patients receive cancer therapy.
	5.3.4 Traitements - AMM (FDA, EMA)
IMBRUVICA® (ibrutinib) Approved by U.S. FDA for the First-line Treatment of Chronic Lymphocytic Leukemia [AbbVie] IMBRUVICA is now approved to treat CLL patients regardless of their treatment history (treatment-naïve and previously-treated patients).
	5.9 AACR
AACR Annual Meeting 2016 Preview [AACR] Watch a preview of the AACR Annual Meeting 2016 from AACR President 2015-2016 José Baselga, MD, PhD, physician-in-chief and chief medical officer at Memorial Sloan Kettering Cancer Center in New York, and AACR Annual Meeting 2016 Program Committee Chairperson Scott A. Armstrong, MD, PhD, director of the Memorial Sloan Kettering Leukemia Center.
	6.1 Observation
Breast cancer diagnosis in pregnancy to rise [The Telegraph] New research from Breast Cancer Care among 496 women aged 45 and under who developed breast cancer has found one in 10 spotted signs while pregnant or breastfeeding.
	6.7 DMP, Big Data & applis
Verily Is Building A Google For Medical Information [Fast Company] "People often ask me about the future of medicine," he said. "We think the most important tool is the computer."
Precision for Medicine Transforms Big Data Into Actionable Information - Bio-IT World Precision for Medicine will formally launch its immuno-analytics platform solution in March of 2016. Its PATH Immunomics suite of advanced analytics solutions and data exploration tools are geared toward the rapid analysis and full visualization of complex cell-based assays, including flow cytometry and multiplexed ELISA biomarkers.
	6.7.2 Applis
For $999, Veritas Genetics Will Put Your Genome on a Smartphone App [MIT Technology Review] Veritas will begin collecting blood or spit samples from customers in April and the first should have their results by June, he says. Its app, still in beta, will include buttons to “share” DNA information with a coach or trainer, and news feeds of medical information customized to a person’s DNA code.
	6.8 Communication
Tapping into Twitter to Help Recruit Cancer Patients into #ClinicalTrials [Penn Medicine] Penn Medicine Researchers Say Twitter Has Potential to Promote Much-needed Trial Recruitment.
	6.9 Controverses
What would a world without cancer really look like? [The Independent] There are better ways of spending some of the money that goes towards research to "cure" cancer, according to a leading medical expert.