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1. Biologie
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IBM's Cancer Moonshot: Using Computer Science To Battle Tumors [Forbes]
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The
idea behind cellular engineering is to scrutinize cell “morphology,” or
the shape and structure of cells, to get to the root of what causes
tumors. Understanding that process could lead to new ways of detecting
and controlling the disease, says Simone Bianco, an Italian physicist
who joined the department of industrial and applied genomics at the IBM
Almaden Research Center in San Jose in 2014.
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Cancer cells’ evasive action revealed [Rice University]
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The
study shows for the first time that some aggressive lung cancer cells
display significantly reduced expression of proteins known as
immunoproteasomes, a key player in the process that signals the immune
system’s T-cells to attack diseased cells.
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2. Etiologie
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Rodent Carcinogenicity Testing: Changes to ICH Guidance Proposed [RAPS]
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The
European Medicines Agency (EMA) is considering changes to International
Council for Harmonisation (ICH) guidance on rodent carcinogenicity
testing to improve the evaluations, reduce use of animals and drug
development resources and reduce timelines to market authorization in
some cases without compromising patient safety.
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2.7 Etiologie - Obésité
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How diet influences colon cancer [MIT News]
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“Not
only does the high-fat diet change the biology of stem cells, it also
changes the biology of non-stem-cell populations, which collectively
leads to an increase in tumor formation.”
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3.1 Tabac
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4.13 Dép., diag. & prono. - Peau
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4.2 Dép., diag. & prono. - Génome
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Does that Gene Sequence Mean What We Think It Means? [In the Pipeline]
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This
paper shows both false negatives and false positives in the existing
data sets. For example, the BRCA2 gene (famously associated with breast
cancer) has a particular variant called rs80359760. It is described in
several databases as pathogenic, but based on the GIAB’s consensus
sequence, this is not accurate.
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4.5 Dép., diag. & prono. - Colorectal
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5. Traitements
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5.12.2 Immunothérapies - CAR-T
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5.2.3 Pharma - économie
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Syndax Cuts Price But Bags $53M in Second IPO Try [Xconomy]
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The
strategic shift is apparent in Syndax’s latest IPO prospectus, which
describes entinostat as a potential “combination therapy in multiple
cancer[s],” rather than the therapy for “treatment resistant cancers” it
was called in Syndax’s 2014 IPO filing. Combination trials with
Merck’s pembrolizumab and Genentech’s atezolizumab should produce
results this year.
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5.4 Traitements - Economie
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6. Lutte contre les cancers
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6.7 DMP, Big Data & applis
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