Onco Actu du 25 mars 2016

	1. Biologie
A lab-made cell shows why ‘disease genes’ are so elusive [STAT] The 473 genes are not the minimal genome. They are a minimal genome. If Venter’s team grew the bacteria in different conditions, or settled for slower growth — the population of bugs with 473 genes doubles every three hours — they’d have a different set.
After 20 Year Quest, Biologists Create Synthetic Bacteria With No Extra Genes [Forbes] “I’d say mission accomplished,” says George M. Church, the Robert Winthrop Professor of Genetics at Harvard Medical School and a synthetic biology pioneer. “It’s not every day that such a big group spends 20 years on something and do what they set out to do.”
The Mysterious Thing About a Marvelous New Synthetic Cell [The Atlantic] Scientists have created a bacterium with a minimal, life-sustaining genome, but they don’t know what a third of its genes do.
	4.10 Dép., diag. & prono. - Poumon
New Data with FoundationOne® Supports Clinical Utility and Improved Outcomes from Molecularly Matching Non-Small Cell Lung Cancer Patients to Targeted Therapy [Foundation Medicine] Data Published in Peer-Reviewed Journals Provide Further Evidence of the Ability of Comprehensive Genomic Profiling to Find Clinically Relevant Alterations Often Missed by Hotspot Assays.
	4.12 Biopsies liquides
Biomarkers and Liquid Biopsy for Early Detection of Colorectal Cancer [CANCER RESEARCH Catalyst] In early-stage colorectal cancer, 80 percent of patients will be fine without chemotherapy after surgery. But there’s 20 percent who need it. The liquid biopsy could potentially help identify the 20 percent so they can get the extra treatments they need.
	4.9 Dép., diag. & prono. - Sein
Digital mammography may also reveal heart disease risk [Reuters] Senior author Dr. Laura Margolies told Reuters Health by email that after digital mammography, “Women should ask their radiologists if there was any calcification in their breast arteries. This information can then be given to their primary care doctors to be used in conjunction with standard risk factors to determine if further evaluation (or treatment) would be of benefit.”
	5. Traitements
Combined Inhibition of DDR1 and Notch Signalling for KRAS-Driven Lung Adenocarcinoma [ESMO] The concomitant inhibition of both DDR1 and Notch signaling induced the regression of KRAS; TP53-mutant patient-derived lung xenografts with a therapeutic efficacy that was at least comparable to that of standard chemotherapy.
	5.2 Pharma
Inside Berg: the pharma startup fighting cancer with AI [Wired] The story of BPM 31510 begins with the extraction of biological data from healthy and cancerous tissue samples from over 1,000 patients. This data was then processed by artificial intelligence algorithms, which analysed it and suggested possible drug treatments.
	6.10 Politiques
Cancer research 'moonshot' wins enthusiastic support in STAT-Harvard poll [STAT] The findings suggest that Obama and Biden can count on broad support for the cancer moonshot funding — as long as they and the Republicans who control Congress can agree how to pay for it.
	6.4 Médico-éco
Capturing the Value of Biomedical Research [Cell] To meaningfully assess impact and capture the effects of research efforts, we developed a strategy to build a highly integrated science information system, called “Science First Information System (SFIS),” which sees science—not administration—as its main currency.
	6.6 Publications
ASH to Expand Family of Blood Journals with Launch of New Cutting-Edge Publication [ASH] An online platform that provides opportunities for increased communication between authors and readers will be a hallmark of ASH’s new publication.
	6.8 Communication
Breast cancer-detecting bra won’t go away--and the news coverage is still sub-par [HealthNewsReview] Most importantly, the researchers say the bra is still in prototype stage and requires more extensive studies, but you’d never guess it from the breathless media coverage.
	6.9 Controverses
Failure Is Moving Science Forward [FiveThirtyEight] The replication crisis is a sign that science is working.