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1. Biologie
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Paving the way for metastasis [MIT News]
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Studying
mice, the researchers found that cancer cells with a particular version
of the Mena protein, called MenaINV (invasive), are able to remodel
their environment to make it easier for them to migrate into blood
vessels and spread through the body. They also showed that high levels
of this protein are correlated with metastasis and earlier deaths among
breast cancer patients.
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3.1 Tabac
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4. Dépistage, diagnostic et pronostic
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4.5 Dép., diag. & prono. - Colorectal
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5. Traitements
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HIV drug could stop skin cancer becoming drug-resistant [Cancer Research UK]
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The
HIV drug, called nelfinavir, works by blocking the molecular switch
which boosts cells’ ability to survive treatment. The research, carried
out in mice, suggests that nelfinavir could be used in combination with
standard skin cancer treatments to make them more potent and delay drug
resistance, making available treatments effective for a longer period of
time.
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Nano-balls filled with poison wipe out metastatic cancer in mice [Science]
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The
treatment, he explains, works in three steps to place a conventional
chemotherapeutic agent near the nucleus (or nuclei) of a metastatic
cancer cell where the drug molecules are most lethal. “It’s almost like a
multistage rocket” that lifts astronauts off Earth, sends them to the
moon, and returns them safely, he says.
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5.12 Immunothérapies
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A lung cancer vaccine from Cuba [ACS]
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Currently
we do not have the information we need to have to know whether or not
this vaccine could be useful in treating lung cancer or possibly be used
to prevent cancer in patients at high risk of developing lung cancer.
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Cancer versus immunological diversity [The Darwin Cancer Blog]
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Perhaps
the best prospects for this new wave of immunotherapy will be to
combine it with drugs that operate through entirely separate pathways.
In the meantime, we should ignore the hyperbole in the headlines and
celebrate some excellent science that brings together genomics, clonal
diversity and the versatility of the immune system.
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5.12.2 Immunothérapies - CAR-T
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5.2 Pharma
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Celator stock soars after leukemia treatment shows survival benefit [Reuters]
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In
the Phase III study of 309 patients with secondary, or high risk, acute
myeloid leukemia, those who received Vyxeos, also known as CPX-351, on
average lived for 9.6 months after the start of the trial. That compared
with 6 months for those who got the standard combination treatment of
cytarabine and daunorubicin.
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5.3 Traitements - FDA, EMA,...
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5.5 ASCO
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5.6 ESMO
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ESMO Appoints First Chief Medical Officer [ESMO]
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The
appointment of Professor Douillard follows an extensive six-month
selection process open to all ESMO members with the necessary high-level
qualifications and experience for the role. Candidates were also
required to have held senior ESMO leadership positions.
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6. Lutte contre les cancers
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6.1 Observation
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6.10 Politiques
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