Onco Actu du 9 février 2016

	1. Biologie
Cancer Detected in Naked Mole Rats [The Scientist] Although the animals can live for 30 years, there have been no documented cases of malignancies in naked mole rats—until, that is, last week (February 4).
	2.7 Etiologie - Obésité
Obese Mice Suggest Cancer Link [National Cancer Institute] In this study, Dr. Waldman and his colleagues followed up on findings in previous studies that, in humans and animals, the loss of guanylin contributes to the development of colon cancer by silencing the expression of its receptor on the epithelial cells that line the intestine.
	3.3 Prévention - Vaccins
Current Global Pricing For Human Papillomavirus Vaccines Brings The Greatest Economic Benefits To Rich Countries [Health Affairs] Subsidizing vaccine prices in low- and middle-income countries could both reduce financial barriers to vaccine adoption and still allow high-income countries to retain their economic surpluses and manufacturers to retain their profits.
	3.5 Prévention - UV
Sunlight exposure: risks and benefits [NICE] This guideline covers how to communicate the risks and benefits of natural sunlight exposure (specifically, the ultraviolet rays UVA and UVB) to help people understand why they may need to modify their behaviour to reduce their risk of skin cancer and vitamin D deficiency.
No such thing as a safe tan from sunlight, warns health watchdog [The Guardian] The report, from the National Institute for Health and Care Excellence (Nice), also says adults need between six and eight teaspoons (35ml) of sun cream with each application and should always aim for an SPF of 15 or higher.
No such thing as a safe tan, warn health officials [The Telegraph] It urges people to refrain from complimenting a “healthy tan” or talking about the benefits of “escaping to the sun”.
	4.1 Dép., diag. & prono. - Prostate
Drop in prostate cancer screening reveals split among doctors [Reuters] The limited drop in PSA testing by urologists probably reflects a belief among specialists that they’re doing what’s best for patients, as well as a payment system that rewards more screening, not less.
	4.12 Biopsies liquides
Hope that blood test 'could diagnose five types of cancer' [NHS Choices] The media has highlighted the benefits of a blood test being "non-invasive", but current screening tests for bowel and breast cancer – taking stool samples and using mammograms, for instance – are also non-invasive.
	4.9 Dép., diag. & prono. - Sein
ASCO Issues New Guideline on Use of Biomarkers to Guide Early Breast Cancer Therapy Decisions [ASCO] The panel conducted a systematic review of literature published from January 2006 through September 2015 and identified 50 relevant studies.
	5. Traitements
From Bench To Blog - When Nostradamus got it right about cancer treatment [The Institute of Cancer Research] Nostradamus seems to have got one thing right: he predicted that sound waves would kill cancer. Here at The Institute of Cancer Research we are helping to prove that this is, in fact, true.
Fighting cancer with cancer: an 'out-of-the-box' approach [STAT] According to Arap, any kind of cancer therapy could be engineered into the tumor cells in this way. “We used TNF as a proof of concept, but you could use whatever gene you’d like,” he said.
Exploring the Growing Interest in Drug Repurposing in Oncology [ESMO] A new joint study to identify trends in the repurposing research activity and its impact, geographical spread and the relative funding compared to other areas of research in cancer.
Turning Tumor Cells Against Cancer [The Scientist] “This paper is an elegant example of thinking outside the box,” said Elizabeth Comen, a medical oncologist and researcher at Memorial Sloan Kettering who was not involved with the work. “To leverage the cancer cell’s powerful ability to travel all over the body against tumors is fascinating.”
	5.2 Pharma
Pfizer keeps pushing on early hit Ibrance as Novartis, Lilly rivals near market [FiercePharmaMarketing] Overall, the drug (palbociclib) is part of 88 ongoing investigational trials--38 of which are in tumor types other than breast cancer.
AstraZeneca's cancer checkpoint combo looks promising in small lung cancer study [FierceBiotech] The pharma giant is reporting that a combination of the PD-L1 drug durvalumab combined with the CTLA-4 treatment tremelimumab achieved an objective tumor response rate of 23% for metastatic non-small cell lung cancer patients.
	5.2.1 Pharma - Partenariats
Start of Phase I clinical trial of monalizumab in combination with durvalumab [Innate Pharma] Trial performed by AstraZeneca/MedImmune in the United States and in Europe. The rationale of the combination of durvalumab and monalizumab will be presented at a scientific meeting during 2016.
Two Drug Companies Rewrite Some Cancer Biochemistry [In the Pipeline] Novartis and Pfizer were both trying to come up with cancer therapies, drugs to take to the clinic and eventually sell for money, and that sounds pretty applied. But to get there, cellular pathways had to be untangled and questioned, and that sounds like nothing else than basic research.
	5.2.3 Pharma - économie
PhRMA kicks off new ad campaign to doctor pharma's tarred image [FiercePharma] PhRMA will run many of the ads on social media sites such as Facebook, LinkedIn and Twitter--where much of the drug pricing debate has played out--because the group wants to home in on federal and state lawmakers, policy analysts and other "political influencers."
	6. Lutte contre les cancers
Transforming Cancer Care in Africa: A Roadmap for Cancer Control [CANCER RESEARCH Catalyst] AORTIC is the premier organization for cancer research and training dedicated to the promotion of cancer control and palliation in Africa.
	6.10 Politiques
Biden’s Moon Shot and the 21st Century Cures Bill [THCB] It is a positive development that policymakers are focused on increasing the funding of and improving medical research and new ways to treat disease. But buried in the Cures Act, the cancer moon shot, and the precision medicine initiative are some poorly conceived ideas and unrealistic assumptions.
	6.11 Patients
Men With Breast Cancer Can Miss Out On Help [NPR] Breast cancer clinics are often decorated in lots of pink, and support systems are designed with women in mind. Giordano recalls one male patient who, after a biopsy, was given a pink floral ice pack that came with instructions to "place it inside your bra."
Leukaemia victim, 24, who sparked worldwide #Match4Lara appeal, finds a stem cell donor [The Telegraph] Since the appeal was launched a month ago, blood cancer charity Anthony Nolan said it received an "unprecedented" spike in new applicants to the stem cell register, with 15,600 new sign-ups and an almost seven-fold increase in black, Asian, ethnic minority or mixed-race (BAME) donors.
	6.6 Publications
2014 ORI finding results in retraction of cancer paper with manipulated images [Retraction Watch] The main conclusions of the paper are affected by the ORI finding, according to the retraction note from Molecular Cancer Therapeutics.