Onco Actu du 3 février 2016

	2.12 Etiologie - UV
Indoor tanning linked to melanoma among young women [Reuters] In a study of people under age 50 with melanoma - the deadliest skin cancer – the women who had tanned indoors were six times more likely than those who did not to have the cancer diagnosed before age 30.
	3.3 Prévention - Vaccins
The HPV Vaccination Crisis [National Cancer Institute] A two-dose schedule will help busy providers and parents get HPV vaccine for adolescents. It’s also important that the money we save on that third dose can go toward reaching the many communities that do not have adequate vaccination services.
	3.8 Prévention - Alimentation
Young women with high-fibre diet may have lower breast cancer risk [NHS Choices] The study also had a number of limitations that affect the accuracy of its measurements – for example, the fact that women reported their adolescent diet when they were middle aged (33 to 52). It is unlikely they would accurately recall their diets from 20 or so years ago.
	4.5 Dép., diag. & prono. - Colorectal
Backing from their GP could lead thousands more to take bowel cancer test [Cancer Research UK] The research involved more than 265,000 people and showed that a higher percentage completed the screening test after receiving the endorsed letter than the usual letter. Across England, this increase in uptake could mean up to almost 40,000 more people being screened for bowel cancer every year.
	5. Traitements
Grand Challenge seven: kill cancer cells using new ‘smart drugs’ [Cancer Research UK] "If we can figure out how to get macromolecule inside all cells, the rest will take care of itself – the drug will distinguish a healthy cell from a cancer cell and leave it alone.”
Drugs Purely From Academia [In the Pipeline] That 17% figure from the EMA might be more accurate, but even that’s high compared to this data set. Maybe those years were particularly rich? We shall see.
	5.10 Traitements - Essais
Make journals report clinical trials properly [Nature News & Comment] Annals’ response helps to explain why studies repeatedly find outcome-switching to be hugely prevalent, despite policies to prevent it. But journal editors now need to engage in a serious public discussion on why this is still happening.
	5.12 Immunothérapies
How to facilitate development of cancer immunotherapies [European Medicines Agency] Experts will discuss appropriate patient population selection, new clinical trial designs, the rationale for the mechanism of action in different tumour types, innovative immunological-based products used in combination, and assessment of relative efficacy of these novel medicines.
	5.2.1 Pharma - Partenariats
GSK and Adaptimmune expand strategic immunotherapy collaboration [GSK] Under the terms of the expanded agreement, the companies will accelerate the development of Adaptimmune’s NY-ESO therapy into pivotal studies in synovial sarcoma and will explore development in myxoid round cell liposarcoma.
	5.2.3 Pharma - économie
Sanofi chops into R&D operations in France in latest retrenchment [FierceBiotech] Bloomberg notes that the pharma giant is eliminating close to 300 open positions in its French R&D operation, another 100 corporate jobs and 155 positions in the commercial division.
	6. Lutte contre les cancers
Fertility issues for cancer patients can also bring legal headaches [Reuters] “Decisions regarding fertility preservation need to be made quickly so the patient can start their oncologist’s treatment plan,” Fournier said by email. “It is difficult to expect a patient to try to anticipate the future legal consequences of their fertility treatment while being faced with those competing pressures.”
Are we fighting cancer the right way? [BBC News] A huge amount of effort and money is spent fighting cancer globally. But are we getting that fight right?
	6.1 Observation
'Western lifestyle’ may play role in higher bowel cancer rates [Cancer Research UK] But while the findings suggest that the adoption of a Western lifestyle may have a role to play in the development of the disease, better detection in these regions may also be having a significant impact on the higher levels of reported incidence.
	6.10 Politiques
$1 Billion Planned for Cancer ‘Moonshot’ [NY Times] “The good news is that the budget is no longer being cut,” said Dr. Peter Adamson, the chairman of the Children’s Oncology Group, which conducts national clinical trials. “But we’re not going to the moon on $1 billion.”
The National Cancer Moonshot Begins to Take Shape [National Institutes of Health] To share the news, the National Cancer Institute Acting Director Dr. Doug Lowy and I fielded many questions from the public during a Twitter chat using #CancerMoonshot, where it was apparent that we weren’t the only ones excited about the effort. One of the most-asked questions was how can people get involved to help shape the initiative.
	6.11 Patients
Why I let a brain tumor go untouched for 10 years [Washington Post] “As a health journalist I’d always thought there was great benefit in early detection. However my experience has made me question the wisdom of learning about an abnormality if all it offers is anxiety — as well as potential harm from treatments for something that might never affect my health.”
	6.6 Publications
Sharon Begley’s Brief Guide to Writing Medical News [The Open Notebook] Somehow, medical writers forget (or never learn) that they are supposed to be journalists, not cheerleaders, and that to serve their readers or listeners they need to bring as much scrutiny, skepticism, and critical thinking to their field as the politics reporter brings to a candidate’s tax plan.