Onco Actu du 2 février 2016

	1. Biologie
Cancer Cells Travel Together to Forge ‘Successful’ Metastases [Johns Hopkins] According to Ewald, conventional wisdom holds that cancer cells leave tumors one by one to colonize other areas of the body, but clinical and genetic evidence has mounted over the last 10 years to suggest otherwise.
	3.1 Tabac
Pfizer's Chantix is no better than nicotine patches, study finds [STAT] Although equally effective as the other options, Chantix did yield higher side effect rates — about 29 percent of the patients experienced nausea, 23 percent reported having vivid dreams, and 22 percent suffered insomnia, according to the study.
	3.3 Prévention - Vaccins
CDC Endorses A More Effective HPV Vaccine To Prevent Cancer [NPR] The new vaccination schedule recommends that 9- and 10-year-olds receive the HPV vaccine if they have a history of sexual abuse.
	3.8 Prévention - Alimentation
High-fiber diet tied to lower breast cancer risk in women [STAT] Harvard researchers pulled data from more than 90,000 women who filled out questionnaires about their health back in 1991, when the women were between ages 27 and 44.
Dietary fiber in teen years may lower later breast cancer risk [Reuters] Researchers analyzed data on more than 44,000 women participating in a long-term study and found those who ate the most fiber during high school and early adulthood were about 20 percent less likely to develop breast cancer by middle age than those who ate the least fiber in their youth.
	4.10 Dép., diag. & prono. - FDA, EMA, NICE,...
E18 Step 3 on genomic sampling and management of genomic data - WC500200837.pdf The main objective of this guideline is to provide harmonised principles of genomic sampling and management of genomic data in clinical studies.
	4.12 Biopsies liquides
Blood Test Offers An Amazing View Of Metastatic Prostate Cancer Cells [Forbes] Outside of clinical trials and collaborative studies with pharmaceutical companies, Prahalad expects the price of an Epic Sciences CTC assay to fall between $2,000 and $2,500.
	5. Traitements
Chemotherapy drug boosts survival for newly diagnosed prostate cancer [The Institute of Cancer Research] A team including researchers from The Institute of Cancer Research and The Royal Marsden found that the chemotherapy drug docetaxel prolonged survival for men starting standard hormone therapy. Men on the combination lived an average of 10 extra months, compared with hormone therapy on its own.
CRISPR gene editing: new chapter in cancer research or blot in the ethical copybook? [Cancer Research UK] For now, this won’t directly offer insights into cancer. But the potential is there as the technology develops, which is why we have signed up to a joint statement describing the use of this technology in human cells and committing to public discussion.
Proton beam therapy 'effective' and 'causes fewer side effects' [NHS Choices] "Although a randomised trial is the best way to obtain a proper comparison cohort, both clinical leaders in the UK and the US deem randomised trials of proton and photon radiotherapy in children to be both unethical and not feasible".
	5.10 Traitements - Essais
NCI-MATCH: A Status Report and Future Directions [National Cancer Institute] Because our experience to date is leading to some modifications in the trial, the pause in enrollment to the screening step is expected to continue until all of these changes are implemented. We expect to resume enrollment of new patients by May 2016.
	5.2 Pharma
Exelixis Announces Positive Overall Survival Results from METEOR, the Phase 3 Pivotal Trial of Cabozantinib in Advanced Renal Cell Carcinoma [Exelixis] First therapy to demonstrate improvement in overall survival, progression-free survival, and objective response rate in a large, pivotal phase 3 study in previously treated renal cell carcinoma patient.
Exelixis Kidney Cancer Survival Benefit Doesn't Address Competitive Question [TheStreet] Exelixis is staying mum on details of the Cometriq survival benefit despite the widely held belief that the company faces a significant challenge luring kidney cancer patients away from Bristol and Opdivo.
	5.2.1 Pharma - Partenariats
Dana-Farber Cancer Institute's Belfer Center announces Immuno-Oncology research collaboration with Array BioPharma -[Dana-Farber Cancer Institute] Combining Dana Farber’s oncology expertise with the Array’s proficiency in drug discovery provides a unique opportunity to accelerate drug discovery of effective medicines for patients with unmet medical need.
	5.4 Traitements - Economie
Sun hopes cut-price generic Gleevec will win third of U.S. market [Reuters] Gleevec, or imatinib mesylate, costs up to about $90,000 annually in the United States, implying Sun's price could be roughly $60,000.
Compassion, Drug Prices, and Money [In the Pipeline] More often than not, academic research discovers general principles and concepts, while industrial research reduces them to practice as medicines. If you believe that this reduction to practice is basically trivial, once the first discovery has been made, you are wildly incorrect, and I only wish that you could try it sometime to experience it firsthand.
	6.10 Politiques
FACT SHEET: Investing in the National Cancer Moonshot [White House] The Administration is launching the National Cancer Moonshot with a $1 billion initiative to provide the funding necessary for researchers to accelerate the development of new cancer detection and treatments.
Partisan split threatens progress on bill to speed drug approvals [STAT] The Republicans’ main interest in the 21st Century Cures bill is streamlining certain Food and Drug Administration requirements for getting new drugs and medical devices on the market. Democrats have said they will not support the legislation without additional funding for the NIH and the FDA.
Obama's $1 Billion Cancer 'Moonshot' May Not Achieve Orbit [Bloomberg] It costs about $1.4 billion, on average, to develop and bring to market a single new drug, according to researchers at Tufts University in Boston. Obama has proposed spending four times as much -- $4.1 billion -- over the next three years to teach schoolchildren how to write basic computer code.
$1 Billion Planned for Cancer ‘Moonshot’ [NY Times] “The good news is that the budget is no longer being cut,” said Dr. Peter Adamson, the chairman of the Children’s Oncology Group, which conducts national clinical trials. “But we’re not going to the moon on $1 billion.”
Obama to seek $755 million in new funding for cancer research in U.S. budget: White House [Reuters] The push will begin this year with $195 million in new cancer work at the National Institutes of Health (NIH). Congress already approved that funding at the end of last year as part of a budget deal. Obama also will ask for $755 million in new, mandatory multi-year spending, mainly for the NIH.
	6.9 Controverses
Toddler dies of leukaemia after medics miss condition 35 times [The Telegraph] A toddler died of leukaemia after medics repeatedly failed to diagnose the condition despite numerous "red flags" and 35 separate visits to doctors and hospitals.