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3.1 Tabac
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Among
women under 35 there were even small but noticeable increases in
smoking in the last year, according to the figures from the Office for
National Statistics.
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3.2 Prévention - Obésité
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A
20 per cent tax on sugary drinks could reduce obesity rates in the UK
by five per cent by 2025 - equal to 3.7 million fewer obese people -
according to a new report from Cancer Research UK and the UK Health
Forum published today.
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4. Dépistage, diagnostic et pronostic
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A
team at Memorial Sloan Kettering Cancer Center in New York is training
an artificial intelligence to find similarities between cases that human
doctors might miss. The software combs through 100 million sentences
taken from clinical notes about people with cancer.
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4.9 Dép., diag. & prono. - Sein
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Penn Medicine Study Offers First Look into Long Term Performance of 3D Mammography Screening.
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The
findings provide longitudinal evidence that the benefits of 3D
MAMMOGRAPHY™ exams – fewer women called back, more cancer cases found in
recalled patients, and fewer cancers diagnosed between regular
scheduled screenings – can be sustained and even improved over time with
consecutive use.
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5. Traitements
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It’s
not just another “whither the drug industry” think piece, of which we
have plenty already. This one get quantitative, attempting to figure out
what the real problems are and to what degree each contribute.
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5.10 Traitements - Essais
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“You’d
like to think that academic institutions are role models for science,”
said Yale Medical School Professor Harlan Krumholz, a co-author of the
study. “The truth is we’re not doing very well.”
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5.12 Immunothérapies
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There are many experimental and clinical examples of naturally acquired or immunotherapy-acquired resistance.
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5.12.2 Immunothérapies - CAR-T
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Bluebird
bio has launched its first clinical study of its CAR-T therapy bb2121
for multiple myeloma. And Celgene has jumped in alongside, following up
on its option for an exclusive license and handing over a $10 million
payment to secure the deal.
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Cai
Xuan, GlobalData’s Analyst covering Oncology and Hematology, has said
that the optimism must be approached with caution: “The cost of T-cell
therapy is currently estimated at a staggering $300,000 per patient,
with some estimates pegging the cost at over $500,000,” he says.
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Stanley
Riddell, at the Fred Hutchinson Cancer Research Centre in Washington
state, creates cells that target a molecule, called CD19, that is found
on the surfaces of some cancers. A firm called Juno Therapeutics is
exploring whether the technique can be used to treat cancers that affect
B-cells, another part of the immune system.
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5.2 Pharma
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The
Breakthrough Therapy designation for PKC412 (midostaurin) is primarily
based upon the positive results from the Phase III RATIFY (CALGB 10603)
clinical trial. This study was conducted in partnership with the
Alliance for Clinical Trials in Oncology and presented during a plenary
session at the 57th American Society of Hematology (ASH) Annual Meeting.
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5.2.3 Pharma - économie
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Merrimack
Pharmaceuticals used the Adimab discovery platform to come up with
three distinct antibodies that bind with different regions, known as
epitopes, found on the EGFR receptor. Cancer researchers know that
target well, because of Eli Lilly’s success with cetuximab (Erbitux), as
a treatment for colorectal cancer.
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6. Lutte contre les cancers
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In
a special three-part essay, ICR Chief Executive Professor Paul Workman
reflects on five decades of advances in cancer treatment – inspired by
The Death of Cancer, an account by clinical research pioneer and
ex-Director of the US National Cancer Institute Vincent DeVita.
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This
was both a research-in-progress forum and a celebration of outstanding
collaborative translational and clinical cancer research.
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6.1 Observation
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Fourteen
people being treated for cancer at Leicester Royal Infirmary have
developed swine flu, forcing the hospital to stop admitting new patients
to three wards and to prevent friends and relatives visiting.
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Men
had 23 percent higher odds of getting these aggressive treatments when
they lived in densely populated U.S. counties than if they resided in
rural counties, according to the analysis of cancer registry data for
about 138,000 men.
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6.11 Patients
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For
my patient, I came to see, treatment was inextricably linked to hope,
and I suspected that it was her hope, much more than the chemotherapy,
that had kept her going years beyond what I would have predicted. But I
was the one who had to keep writing orders for the chemotherapy, albeit
in low doses, that was keeping her hope, and thus her, alive. Was that
so wrong?
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6.7 DMP, Big Data & applis
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“Locky”
— the nickname of a new strain of ransomware that arrives in an email
with a Word doc attached — can shutdown U.S. hospital computer systems
along with the equipment used to treat cancer patients.
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The
basic idea with the Truven deal is to merge complementary data sets.
Watson Health has a wealth of data on clinical studies and patient
engagement, as well as the ability to read and analyze the literature.
Truven brings data and analytics on healthcare costs, claims, and
outcomes from health plans, employers, and other organizations.
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While
recent developments are encouraging and the government does seem
convinced of the value of digital health technology, it will be years
before patients routinely see practical improvements to the way their
care is provided and managed.
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