Onco Actu du 18 février 2016

	1. Biologie
US cancer institute to overhaul tumour cell lines [Nature News & Comment] Veteran cells to be retired in favour of fresh tumour samples grown in mice.
	2.4 Etiologie - Portables, ondes e-m
Electromagnetic radiation doesn't make you ill or give you cancer. Here's why [The Guardian] Most EMR is invisible and inescapable, and apprehension over what we cannot see is completely understandable. But if we are to make informed decisions on health and technology, misplaced fear of the unknown or dogmatic convictions are simply no substitute for evidence and understanding.
	3.3 Prévention - Vaccins
No, Gardasil does not cause behavioral problems [Respectful Insolence] Basically, this study is worthless, as it’s unblinded and doesn’t use the correct statistical analysis. Had I been a reviewer, I would have pointed these issues out and recommended rejecting the paper.
	4. Dépistage, diagnostic et pronostic
MD Anderson researchers propose new staging for HPV-related oropharyngeal cancer [MD Anderson] Current staging system is inadequate; for the first time, research proves that staging based on nasopharyngeal “N” categories offers more predictive value.
	4.2 Dép., diag. & prono. - Génome
If You Want Life Insurance, Think Twice Before Getting A Genetic Test [Fast Company] As genetic testing explodes, health insurers are banned from denying coverage based on results. The same doesn't apply for life insurance.
	4.9 Dép., diag. & prono. - Sein
More young breast cancer patients having genetic tests [Reuters] In recent years, more than 95 percent of U.S. women diagnosed with cancer at age 40 or younger got tested for mutations that raise their risk of future cancers, according to a new study.
	5. Traitements
How Do We Overcome Endocrine Therapy Resistance in Breast Cancers? [CANCER RESEARCH Catalyst] Future approaches will include combination therapy of mTOR/PI3K inhibition and FGFR inhibition.
	5.12 Immunothérapies
Immune-Targeting Drug Combo Shows Promise for Non-Small Cell Lung Cancer Patients, Say Moffitt Cancer Center Researchers [Moffitt] Researchers enrolled 102 patients in with advanced non-small cell lung cancer in the phase 1b study to evaluate the durvalumab and tremelimumab combination therapy.
	5.2 Pharma
Roche and AstraZeneca snag 'breakthrough' tags for a pair of blockbusters in waiting [FierceBiotech] AstraZeneca has projected peak sales of $6.5 billion for durvalumab, but the changing landscape for so-called checkpoint inhibitors could put that goal out of reach.
	5.2.1 Pharma - Partenariats
Effimune, In Cell Art Launch Cancer Immunotherapy Collaboration [GEN] Effimune and In Cell Art are startups both based in Nantes, France.
Ipsen enters into a licensing agreement with 3B Pharmaceuticals to develop novel radiopharmaceuticals in oncology [Ipsen] Ipsen acquires exclusive worldwide rights to develop and commercialize novel radiopharmaceuticals targeting the neurotensin receptor.
	6. Lutte contre les cancers
The Guardian view on cancer cures: not the only killer disease [The Guardian] The billions that go into trying to find a cure might save more lives if they were spent on better understanding heart and lung disease.
	6.1 Observation
UK cancer cases soar to 352,000 each year [Cancer Research UK] The new figure compares with more than 253,000 people getting the disease every year two decades before.
Elderly risk more complications after major cancer surgery [Reuters] To see how age influences the risk of post-operative complications, Tan and colleagues reviewed hospital admission records for a nationwide sample of 940,000 adults age 55 and older who had cancer surgery from 2009 to 2011.
	6.10 Politiques
Investing in the US National Cancer Moonshot [ESMO] Together, these investments represent an initial down-payment on the US National Cancer Moonshot. Over the coming months, the US Administration looks forward to working with Congress to launch the next phase of investments, providing the resources needed to double a rate of progress in this historic fight.
	6.11 Patients
Listening To The Voice Of The Patient In Precision Medicine [Forbes] Megan, for instance, had enrolled her daughter Shannon in a program for undiagnosed diseases at the NIH, and had subjected her to an exhaustive battery of tests. Yet when Megan subsequently attempted to receive a copy of Shannon’s reports, she was told “sorry, this was done under a research protocol – we can’t give this information to you.”
	6.3 Associations
How a cancer diagnosis led to nation’s first crowdfunding platform for medical research [Scope] The desire to save her daughters from a cancer diagnosis motivated Lindquist to create the nation’s first-ever crowdfunding platform for medical research. Lindquist and her husband, Scott Finkelstein, MD, combined their prodigious business, technology and medical knowledge and skills to build the platform, called Consano, which means “to heal” in Latin.
	6.7 DMP, Big Data & applis
Cancer research moves to the cloud to improve patient care [STAT] Migrating the National Institutes of Health’s Cancer Genome Atlas — or TCGA, as the database is called — could bring faster discoveries in the genetics of cancer, and therefore more successful treatments.
Collaboration Fueling Large-Scale Computational Cancer Science [National Cancer Institute] Through this collaboration, we’re beginning construction of the 21st century digital launchpad needed to conduct next-generation cancer research and providing a framework for the many future missions that will produce critical innovations in cancer treatment.
	6.8 Communication
How narrators for drug ads take scariness out of side effects [STAT] The FDA does insist, however, that the ads rattle off a long, usually grim, list of potential side effects. But how to do it without turning off customers?
AAAS stories hype immunotherapy, cancer saliva test [HealthNewsReview] So, instead of the words at the top of the post, the reigning headline themes should perhaps be: “Interesting” “Caution” “Too Early to Tell”.