Onco Actu du 15 février 2016

	1. Biologie
Gene Previously Observed Only in Brain is Important Driver of Metastatic Breast Cancer [Wistar Institute] “We believe this is the first time that anyone has demonstrated the importance of RNA editing in breast cancer,” Huang said. “A combination strategy that that involves targeting Gabra3 while also upregulating the expression of RNA editing molecules could be an effective strategy for managing metastatic breast cancer.”
	2. Etiologie
Oral HPV16 Infection Precedes Head and Neck Cancer [National Cancer Institute] Previous studies have established an association between HPV-16 infection and oropharyngeal cancer, a type of head and neck cancer. The new study is the first to do so using samples collected from participants prior to their cancer diagnosis.
	4.12 Biopsies liquides
New 10 minute test for cancer developed by scientists [The Telegraph] The test is non-invasive and cheap, costing around just 15 pounds. It is due to enter full clinical trials in lung cancer patients later this year, and is expecting approval within two years from the Food and Drug Administration in America.
	4.2 Dép., diag. & prono. - Génome
Consumers aren't wild about genetic testing — nor are doctors [STAT] “Until we have more large-scale studies showing the benefits of genetic testing, I doubt there will be much push to perform these tests.”
Should you take a genetic test? Here's what experts advise [STAT] A new poll from STAT and the Harvard T.H. Chan School of Public Health found that about half of respondents would consider such a test if it would signal their risk of cancer or Alzheimer’s disease.
	5. Traitements
Targeting cancer from many angles [MIT News] “How could we look at all of those genes and their potential contributions to cancer?” Jacks said. “We didn’t know quite what to do.” Just in time, scientists reported the development of a new genome-editing technique known as CRISPR.
	5.2 Pharma
Clovis looks to rebuild the case for its cancer drug at FDA panel [FierceBiotech] The Boulder, CO, company is slated to appear before the agency's oncology committee on April 12 in support of rociletinib, an oral therapy designed to treat patients with non-small cell lung cancer and mutations in their EGFR genes.
	5.2.3 Pharma - économie
Bristol-Myers shares could rise 25 percent on cancer drug: Barron's [Reuters] Shares of Bristol-Myers Squibb could rise 25 percent within a year because of its cancer-fighting drug Opdivo, which some analysts see generating $8 billion to $9 billion in annual sales in five years.
	5.3 Traitements - FDA, EMA,...
FDA Regulatory Definitions [CRI] You heard that a drug in clinical trials was Fast Tracked. Or you heard that a treatment was granted Breakthrough Therapy by the FDA. Or that it got an Orphan Drug status. But what do these regulatory names mean?
	5.4 Traitements - Economie
'Close to criminal' [Fred Hutch] She was left with a huge portion to pay out of pocket. So much that she finally said, “I cannot continue on this. I have no way of paying for it.” And so she stopped. And she died. That’s as close to criminal as I can think of – a calamity that should never happen to those in this situation in the world’s richest economy.
	6. Lutte contre les cancers
ICER Draft Report on Palliative Care in the Outpatient Setting Posted for Public Comment [lnstitute for Clinical and Economic Review] Draft Findings Suggest Outpatient Palliative Care Improves Quality of Life and Patient Satisfaction While Reducing Hospital and Emergency Room Visits.
	6.1 Observation
Thousands who die with cancer spend last days in pain, study finds [The Guardian] Macmillan says patients in UK should not be spending end of life in pain simply because of poor medical support at home.
	6.10 Politiques
Public Health: ‘Moonshot’ Metaphor on Cancer Is a Failure to Communicate [NY Times] The name suggests a broad, revolutionary new set of initiatives, but the Biden program’s funding represents a tiny fraction of the current national spending on cancer research.
	6.3 Associations
Kathy Giusti: the businesswoman who took on her own cancer [STAT] In 1996, Kathy Giusti was a pharmaceutical executive and mother of a toddler, when she was diagnosed with multiple myeloma, a rare form of blood cancer. With no proven treatments at the time, Giusti decided to make the most of her professional expertise and create a foundation dedicated to funding drug discovery.
	6.5 Médecines alternatives
An alternative cancer cure testimonial, mistletoe, and Johns Hopkins University [Respectful Insolence] It was the good, old-fashioned application surgery to her tumors, because, after all, nothing heals like surgical steel. The question I have is: What the heck is Johns Hopkins doing here, and why would it allow itself to be associated with a woman who also used homeopathic remedies?
	6.8 Communication
Yale hype could raise false hopes for myeloma cancer patients [HealthNewsReview] When you read news issued by Yale University based on a study published in the prestigious New England Journal of Medicine, you might reasonably assume that the information you’re receiving is reliable and devoid of hype. But you’d be wrong in that assumption.