Onco Actu du 22 janvier 2016

	2.5 Etiologie - Gènes
New genetic risk factor for ovarian cancer identified [NHS Choices] The researchers believe this particular type of genetic mutation stops cells repairing their DNA, and this could then lead to cancer.
	4. Dépistage, diagnostic et pronostic
Glowing tumours could help surgeons remove cancer [The Telegraph] Under the new technique patients would be connected to an intravenous drop which sends dye molecules into the blood, where they travel to tumours. The surgeon would then insert a small camera into the patient which would show the tumour glowing bright green.
Some older patients get unnecessary cancer screenings [Reuters] About 16 percent of people aged 65 years and older who shouldn’t get breast or prostate cancer screenings based on their limited life expectancies are still getting tests for these tumors, the study found.
	4.12 Biopsies liquides
Exosome Diagnostics Launches World’s First Exosomal RNA-Based Liquid Biopsy, ExoDx™ Lung(ALK) [Exosome Diagnostics] The test will assist oncologists in identifying patients who may benefit from ALK inhibitory therapy among the population of NSCLC patients whose tissue samples are unavailable or who are unwilling or unable to undergo repeat biopsy.
	4.2 Dép., diag. & prono. - Génome
UK Government’s DNA-mapping project recruits first cancer patients [Cancer Research UK] Sir Harpal Kumar, the charity’s chief executive, said: “It’s very exciting news that the first cancer patients are being recruited to the main phase of this ground-breaking project.
	4.7 Dép., diag. & prono. - Col de l'utérus
'Urban myth' that lesbian women don't need pap smears is a health risk – study [The Guardian] “Lesbian women also don’t usually need access to contraception so they’re not having those opportunistic discussions with their doctors about screening.”
	4.9 Dép., diag. & prono. - Sein
Media case study: PR news release vs. news stories on mammography screenings for older women [HealthNewsReview] We looked at some of the news coverage of the study that appeared after the release. What we found is that news media relied on the release very heavily, didn’t question the primary message and skipped some other steps that would make the story more useful for readers as they try to stay informed about screenings.
	5.10 Traitements - Essais
Good progress in clinical trials transparency, but we need to do more [Cancer Research UK] These highlights of cancer clinical trial practice in the UK show that transparency is possible. Now we need this good practice – clinical trial registration and open reporting of trial results – to be replicated in other disease areas, not just in the UK but around the world, and retrospectively for all the hidden trials of medicines we use today that were conducted in the past.
	5.2 Pharma
Sanofi layoffs expected as reorganization goes into effect [STAT] “They’re facing a very difficult situation,” said David Kliff of Diabetic Investor, who expects the cuts to be significant. “Their top diabetes product is going away and replacement products are not doing well. They have no choice but to reorganize.”
	5.2.1 Pharma - Partenariats
MD Anderson, AbbVie Connect to Advance Cancer Immunotherapy [AbbVie] The three-year collaboration agreement provides a framework for MD Anderson and AbbVie to efficiently choose and carry out preclinical and clinical studies evaluating new ideas in the cutting-edge area of immuno-oncology.
	5.3.4 Traitements - AMM (FDA, EMA)
FDA Approves New Kyprolis Carfilzomib Combination Therapy For The Treatment Of Patients With Relapsed Or Refractory Multiple Myeloma [Amgen] The data showed patients with relapsed multiple myeloma treated with Kyprolis and dexamethasone achieved 50 percent greater PFS of 18.7 months compared to 9.4 months in those receiving Velcade® (bortezomib) and dexamethasone.
FDA gives full approval to Amgen blood cancer drug [Reuters] A trial testing Kyprolis combined with the drug dexamethasone doubled the length of time before the disease progressed compared with a rival drug, Velcade, plus dexamethasone.
	6.1 Observation
Improving cancer survival by understanding how patients are diagnosed [Cancer Research UK] For the first time, we’ve been able to look at both how people are diagnosed (e.g. via a GP referral or by screening) and whether they were diagnosed at an early or late stage.
	6.10 Politiques
Vice President Highlights CancerLinQ™ at World Economic Forum [ASCO] Biden presided over a panel discussion with leading healthcare policy, cancer research, and technology experts that explored the importance of sharing data and improving interoperability of patient information in cancer care, among other issues in cancer research and treatment. Watch the full video which mentions CancerLinQ at the 9:40 mark.
	6.7.3 DMP
How Data Brokers Make Money Off Your Medical Records [Scientific American] Data brokers legally buy, sell and trade health information, but the practice risks undermining public confidence.